The reducing end of αGal oligosaccharides contributes to their efficiency in blocking natural antibodies of human and baboon sera

Transplant International

Volumn 9, Issue 2, 1996, Pages 98-101

  Neethling, Francisca A ^a   Joziasse, David ^b   Bovin, Nicolai ^c   Cooper, David K C ^a   Oriol, Rafael ^d  

^a INTEGRIS Nazih Zuhdi Transplant Institute   (United States)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^d INSERM   (France)

Author keywords

Baboon; Natural antibodies; Oligosaccharides; Xenotransplantation

Indexed keywords

ANTIBODY; GALACTOSE; OLIGOSACCHARIDE;

ANIMAL CELL; ARTICLE; BABOON; CYTOTOXICITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; XENOTRANSPLANTATION;

ANIMALS; ANTIBODIES; AOTIDAE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; OLIGOSACCHARIDES; PAPIO; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0030062283     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00336385     Document Type: Article

References (21)

1. Cooper DKC, Good AH, Koren E, Oriol R, Malcolm AJ, Ippolito RM, Neethling FA, Ye Y, Romano E, Zuhdi N (1993) Identification of a galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man. Transplant Immunol 1: 198-205
2. Cooper DKC, Ye Y, Niekrasz M, Kehoe M, Martin M, Neethling FA, Kosanke S, DeBault LE, Worsley G, Zuhdi N, Oriol R, Romano E (1993) Specific intravenous carbohydrate therapy. A new concept in inhibiting antibody-mediated rejection experience with ABO-incompatible cardiac allografting in the baboon. Transplantation 56: 769-777
3. Cooper DKC, Koren E, Oriol R (1994) Oligosaccharides and discordant xenotransplantation. Immunol Rev 141: 31-58
4. Galili U (1993) Interaction of the natural anti-Gal antibody with α-galactosyl epitopes: a major obstacle for xenotransplantation. Immunol Today 14: 480-482
5. Galili U, Shohet SB, Kobrin E, Stults CLM, Macher BA (1988) Man, apes, and Old World monkeys differ from other mammals in the expression of α-galactosyl epitopes on nucleated cells. J Biol Chem 263: 17755-17762
6. Good AH, Cooper DKC, Malcolm AJ, Ippolito E, Koren E, Neethling FA, Ye Y, Zuhdi N, Lamontagne LR (1992) Identification of carbohydrate structures that bind human anti-porcine antibodies: implications for discordant xenografting in humans. Transplant Proc 24: 559-562
7. Joziasse DH, Shaper JH, Eijnden DH van den, Tunen AJ van, Shaper NL (1989) Bovine α1-3galactosyltransferase: isolation and characterization of a cDNA clone. Identification of homologous sequences in human genomic DNA. J Biol Chem 264: 14290-14297
8. Joziasse DH, Shaper NL, Salyer LS, Eijnden D van den, Spoel AC van den, Shaper J (1990) α1-3-galactosyltransferase: the use of recombinant enzyme for the synthesis of α-galactosylated glycoconjugates. Eur J Biochem 191: 75-83
9. Joziasse DH, Shaper JH, Wang Jabs E, Shaper NL (1991) Characterization of an α1-3-galactosyltransferase homologue on human chromosome 12 that is organized as a processed pseudogene. J Biol Chem 266: 6991-6998
10. Korchagina EY, Bovin NV (1992) Synthesis of spacered trisaccharides with blood group specificities A and B, their fragments and structural analogs. Bioorg Khim 18: 283-298
11. Koren E, Neethling FA, Koscec M, Kujundzic M, Richards SV, Ye Y, Oriol R, Cooper DKC (1994) In vitro model for hyperacute rejection of xenogeneic cells. Transplant Proc 26: 1166
12. Larsen RD, Rivera-Marrero CA, Ernst LK, Cummings RD, Lowe JB (1990) Frameshift and non-sense mutations in a human genomic sequence homologous to a murine UDP-Ga1:β-D-Gal(1,4)-D-GlcNAc α(1,3)galactosyl-transferase. J Biol Chem 265: 7055-7061
13. Neethling FA, Koren E, Ye Y, Richards SV, Kujundzic M, Oriol R, Cooper DKC (1994) Protection of pig kidney (PK15) cells from the cytotoxic effect of anti-pig antibodies by α-galactosyl oligosaccharides. Transplantation 57: 959-968
14. Oriol R, Ye Y, Koren E, Cooper DKC (1993) Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation. Transplantation 56: 1433-1442
15. Oriol R, Barthod F, Bergemer AM, Ye Y, Koren E, Cooper DKC (1994) Monomorphic and polymorphic carbohydrate antigens on pig tissues: implications for organ xenotransplantation in the pig-to-human model. Transpl Int 7: 405-413
16. Rieben R, Allmen E von, Korchagina EY, Nydegger UE, Neethling F, Kujundzic M, Koren E, Bovin N, Cooper DKC (1995) Detection, immunoabsorption, and inhibition of cytotoxic activity of anti-αGal antibodies using newly developed substances with synthetic Galα1-3Gal disaccharide epitopes. Xenotransplantation 2: 98-106
17. Samuelsson BE, Rydberg L, Breimer ME, Bächer A, Gustavsson M, Holgersson J, Karlsson E, Uyterwaal AC, Cairns T, Welsh K (1994) Natural antibodies and human xenotransplantation. Immunol Rev 141: 151-168
18. Sandrin MS, McKenzie IFC (1994) Gal α(1,3)Gal - the major xenoantigens recognized in pigs by human natural antibodies. Immunol Rev 141: 169-190
19. Sandrin MS, Vaughan HA, Dabrowski PL, McKenzie IFC (1993) Anti-pig antibodies in human serum react predominantly with Galα(1,3)Gal epitopes. Proc Natl Acad Sci USA 90: 11391-11395
20. Sandrin MS, Vaughan HA, McKenzie IFC (1994) Galα(1,3)Gal as the major epitope for the pig-to-human vascularized grafts. Transplant Rev 8: 134-149
21. Ye Y, Neethling F, Niekrasz M, Koren E, Richards SV, Martin M, Kosanke S, Oriol R, Cooper DKC (1994) Evidence that intravenously administered α-galactosyl carbohydrates reduce baboon serum cytotoxicity to pig kidney cells (PK15) and transplanted pig hearts. Transplantation 58: 330-337