Reducing lactate accumulation does not attenuate lethal ischemic injury in isolated perfused rat hearts

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 270, Issue 1 39-1, 1996, Pages

  Vander Heide, Richard S ^a   Delyani, John A ^a   Jennings, Robert B ^a   Reimer, Keith A ^a   Steenbergen, Charles ^a,b  

^a DUKE UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

ischemic metabolism; ischemic preconditioning; myocardial injury; myocardial ischemia

Indexed keywords

LACTIC ACID;

AEROBIC METABOLISM; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL SURVIVAL; GLYCOLYSIS; HEART MUSCLE ISCHEMIA; HEART PERFUSION; HIGH ENERGY PHOSPHATE; ISOLATED HEART; KILLER CELL; MUSCLE FUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030062167     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.270.1.h38     Document Type: Article

References (34)

1. Allard, M. F., P. G. Emanuel, J. A. Russell, S. P. Bishop, S. B. Digerness, and P. G. Anderson. Preischemie glycogen reduction or glycolytic inhibition improves postischemic recovery of hypertrophied rat hearts. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H66-H74, 1994.
2. Altschuld, R. A., W. C. Wenger, K. G. Lamka, O. R. Kindig, C. C. Capen, V. Mizuhira, R. S. Vander Heide, and G. P. Brierley. Structural and functional properties of adult rat heart myocytes lysed with digitonin. J. Biol. Chem. 260: 14325-14334, 1985.
3. Anderson, S., E. Murphy, C. Steenbergen, R. E. London, and P. Cala. Na-H exchange in myocardium: effects of hypoxia and acidification on Na and Ca. Am. J. Physiol. 259 (Cell Physiol. 28): C940-C948, 1990.
4. Asimakis, G. K., K. Inners-McBride, G. Medellin, and V. R. Conti. Ischemic preconditioning attenuates acidosis and postischemic dysfunction in isolated rat hearts. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H887-H894, 1992.
5. Cornblath, M., P. J. Randle, A. Parmeggiani, and H. E. Morgan. Regulation of glycogenolysis in muscle: effects of glucagon and anoxia on lactate production, glycogen content and phosphorylase activity in perfused rat heart. J. Biol. Chem. 238: 1592-1597, 1963.
6. De Albuquerque, C. P., G. Gerstenblith, and R. G. Weiss. Importance of metabolic inhibition and cellular pH in mediating preconditioning contractile and metabolic effects in rat hearts. Circ. Res. 74: 139-150, 1994.
7. Ganote, C. E., and S. M. Humphrey. Effects of anoxic or oxygenated reperfusion in globally ischemic, isovolumic, perfused rat hearts. Am. J. Pathol. 120: 129-145, 1985.
8. Ganote, C. E., R. Seabra-Gomes, W. G. Nayler, and R. B. Jennings. Irreversible myocardial injury in anoxic perfused rat hearts. Am. J. Pathol. 80: 419-450, 1975.
9. Ganote, C. E., and R. S. Vander Heide. Irreversible injury of isolated adult rat myocytes. Osmotic fragility during metabolic inhibition. Am. J. Pathol. 132: 212-222, 1988.
10. Garlick, P. B., G. K. Radda, and P. J. Seeley. Studies of acidosis in the ischaemic heart by phosphorus nuclear magnetic resonance. Biochem. J. 184: 547-554, 1979.
11. Geisbuhler, T. P., and M. J. Rovetto. Lactate does not enhance anoxia/reoxygenation damage in adult rat cardiac myocytes. J. Mol. Cell. Cardiol. 22: 1325-1335, 1990.
12. 2+ ATP, and compartmentation. Circ. Res. 49: 1119-1128, 1981.
13. Hearse, D. J., P. B. Garlick, and S. M. Humphrey. Ischemic contracture of the myocardium: mechanisms and prevention. Am. J. Cardiol. 39: 986-993, 1977.
14. Jennings, R. B., K. A. Reimer, and C. Steenbergen. Myocardial ischemia revisited: the osmolar load, membrane damage, and reperfusion. J. Mol. Cell. Cardiol. 18: 769-780, 1986.
15. Kida, M., H. Fujiwara, M. Ishida, C. Kawai, M. Ohura, I. Miura, and Y. Yabuuchi. Ischemic preconditioning preserves creatine phosphate and intracellular pH. Circulation 84. 2495-2503, 1991.
16. 31P-NMR study of isolated rat hearts. Am. J. Physiol. 261 (Heart Circ. Physiol. 30): H469-H478, 1991.
17. 2+], elevation and ATP depletion. Am. J. Physiol. 258 (Heart Circ. Physiol. 27): H9-H16, 1990.
18. Lagerstrom, C. F., W. E. Walker, and H. Taegtmeyer. Failure of glycogen depletion to improve left ventricular function of the rabbit heart after hypothermie ischemic arrest. Circ. Res. 63 81-86, 1988.
19. Lasley, R. D., G. M. Anderson, and R. M. Mentzer, Jr. Ischaemic and hypoxic preconditioning enhance postischemic recovery of function in the rat heart. Cardiovasc. Res. 27: 565-570, 1993.
20. 1 receptor mechanism. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H1460-H1465, 1992.
21. Liu, Y., and J. M. Downey. Ischemic preconditioning protects against infarction in rat heart. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H1107-H1112, 1992.
22. 1 receptors in rabbit heart. Circulation 84: 350-356, 1991.
23. Murphy, E., M. Perlman, R. E. London, and C. Steenbergen. Amiloride delays the ischemia-induced rise in cytosolic free calcium. Circ. Res. 68: 1250-1258, 1991.
24. Murry, C. E., V. J. Richard, K. A. Reimer, and R. B. Jennings. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode. Circ Res. 66: 913-931, 1990.
25. Neely, J. R., and D. Feuvray. Metabolic products and myocardial ischemia. Am. J. Pathol. 102: 282-291, 1981.
26. Neely, J. R., and L. W. Grotyohann. Role of glycolytic products in damage to ischemic myocardium: Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts. Circ. Res. 55: 816-824, 1984.
27. Owen, P., S. Dennis, and L. H. Opie. Glucose flux rate regulates onset of ischemic contracture in globally underperfused rat hearts. Circ. Res. 66: 344-354, 1990.
28. Rovetto, M. J., W. F. Lamberton, and J. R. Neely. Mechanisms of glycolytic inhibition in ischemic rat hearts. Circ. Res. 37: 742-751, 1975.
29. Steenbergen, C., M. L. Hill, and R. B. Jennings. Volume regulation and plasma membrane injury in aerobic, anaerobic, and ischemic myocardium in vitro. Circ. Res. 57: 864-875, 1985.
30. Steenbergen, C., E. Murphy, J. A. Watts, and R. E. London. Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart. Circ. Res. 66: 135-146, 1990.
31. Steenbergen, C., M. E. Perlman, R. E. London, and E. Murphy. Mechanism of preconditioning: ionic alterations. Circ. Res. 72: 112-125, 1993.
32. Vander Heide, R. S., and C. E. Ganote. Increased myocyte fragility following anoxic injury. J. Mol. Cell. Cardiol. 19: 1085-1103, 1987.
33. Vanoverschelde, J.-L. J., M. F. Janier, J. E. Bakke, D. R. Marshall, and S. R. Bergmann. Rate of glycolysis during ischemia determines extent of ischemic injury and functional recovery after reperfusion. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1785-H1794, 1994.
34. Wolfe, C. L., R. E. Sievers, F. L. J. Visseren, and T. J. Donnelly. Loss of myocardial protection after preconditioning correlates with the time course of glycogen recovery within the preconditioned segment. Circulation 87: 881-892, 1993.