Hyperuricaemia in cyclosporin-treated patients: A GFR-related effect

Nephrology Dialysis Transplantation

Volumn 11, Issue 1, 1996, Pages 153-158

  Zurcher R M ^a,b   Bock, H A ^a   Thiel, G ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Bone marrow transplantation; Cyclosporin; Glomerular filtration rate; Organ donors; Renal transplantation; Uric acid

Indexed keywords

CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; INULIN; URIC ACID;

ARTICLE; BONE MARROW TRANSPLANTATION; CLINICAL ARTICLE; CONTROLLED STUDY; GLOMERULUS FILTRATION RATE; HUMAN; HYPERURICEMIA; IMMUNOSUPPRESSIVE TREATMENT; INULIN CLEARANCE; KIDNEY TRANSPLANTATION; LIVING DONOR; PATHOGENESIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; UNINEPHRECTOMY;

EID: 0030061146     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/11.1.153     Document Type: Article

References (17)

1. European Multicenter Trial Group. Cyclosporine in cadaveric renal transplantation: one-year follow-up of a multicenter trial. Lancet 1983; 986-989
2. Lin HY, Rocher LL, McQuillan MA, Schmaltz S, Palella TD, Fox IH. Cyclosporine-induced hyperuricaemia and gout. N Engl J Med 1989; 321: 287-292
3. Noordzij TC, Leunissen KML, van Hooff JP, Letter. N Engl J Med 1990; 322: 335
4. Noordzij TC, Leunissen KML, van Hooff JP. Renal handling of urate and the incidence of gouty arthritis during cyclosporine and diuretic use. Transplantation 1991; 52: 64-67
5. Versluis DJ, Wenting GJ, Jeekel J, Weimar W. Cyclosporine A-related proximal tubular dysfunction: impaired handling of uric acid. Transplant Proc 1987; 19: 4029-4030
6. Cohen SL, Boner G, Rosenfeld JB. The mechanism of hyperuricemia in cyclosporin-treated renal transplant recipients. Transplant Proc 1987; 19: 1829-1830
7. Zürcher RM, Bock HA, Thiel G. Excellent uricosuric efficacy of benzbromarone in cyciosporin-treated renal transplant patients: a prospective study. Nephrol Dial Transplant 1994; 9: 548-551
8. Chapman JR, Harding NGL, Griffiths D. Reversibility of cyclosporine nephrotoxicity after three months' treatment. Lancet 1985; 128-129
9. Palestine AG, Nussenblatt RB, Chan CC. Side effects of systemic cyclosporine in patients not undergoing transplantation. Am J Med 1984; 77: 652-656
10. Grino JM, Sabater I, Castelao AM, Torras J. Cyclosporine, uric acid and the kidney. Lancet 1985; 1: 701-702
11. Najarian JS, Fryd DS, Strand M et al. A single institution. randomized, prospective trial of cyclosporine versus azathioprine-antilymphocyte globulin for immunosuppression in renal allograft recipients. Ann Surg 1985; 201: 142-157
12. Leunissen KML, Bosmann F, van Hooff JP. Cyclosporine, uric acid, and the kidney. Lancet 1985; 1: 702
13. Kahan BD, Flechner SM, Lorber MI, Golden D, Conley S, Van Buren CT. Complication of cyclosporine-prednisone immunosuppression in 402 renal allograft recipients exclusively followed at a single center from one to five years. Transplantation 1987; 43: 197-204
14. West C, Carpenter BJ, Hakal TR. The incidence of gout in renal transplant recipients. Am J Kidney Dis 1987; 10: 369-372
15. Burack DA, Kahl LE, Griffith BP, Thompson ME, Medsger TA Jr. Hyperuricemia and gouty arthritis among heart transplant patients treated with cyclosporine (CY). Arthritis Rheum 1988; 31 [Suppl S48] abstract
16. Tiller DJ, Hall BM, Horvath JS, Duggin GG, Thompson JF, Sheil AG. Gout and hyperuricemia in patients on cyclosporine A and diuretics. Lancet 1985; 453
17. Steele TH, Rieselbach RE. The contribution of residual nephrons within the chronically diseased kidney to urate homeostasis in man. Am J Med 1967; 43: 876-886