N,N′-bis-(3,4,5-trimethoxybenzyl) ethylenediamine N,N′-diacetic acid as a new iron chelator with potential medicinal applications against oxidative stress

Biochemical Pharmacology

Volumn 51, Issue 2, 1996, Pages 103-115

  Galey, Jean Baptiste ^a   Dumats, Jacqueline ^a   Genard, Sylvie ^a   Destree, Odile ^a   Pichaud, Patrick ^a   Cctroux, Philippe ^a   Marrot, Laurent ^a   Beck, Iréna ^a   Fernandez, Bona ^a   Barre, Gilles ^a   Seite, Michel ^a   Hussler, Georges ^a   Hocquaux, Michel ^a  

^a L'Oréal Research Center   (France)

Author keywords

Hydrogen peroxide; Hydroxyl radical; Intramolecular hydroxylation; Iron chelator; Oxidative stress; Site specific reaction

Indexed keywords

ASCORBIC ACID; CHELATING AGENT; DEFEROXAMINE; FERRIC CHLORIDE; HYDROGEN PEROXIDE; IRON CHELATE; IRON COMPLEX; N (2 HYDROXY 3,4,5 TRIMETHOXYBENZYL) N' (3,4,5 TRIMETHOXYBENZYL)ETHYLENEDIAMINE N,N' DIACETIC ACID; N,N' BIS (3,4,5 TRIMETHOXYBENZYL)ETHYLENEDIAMINE N,N' DIACETIC ACID; N,N' BIS(3,4,5 TRIMETHOXYBENZYL)ETHYLENEDIAMINE N,N' DIACETIC ACID DIMETHYL ESTER; OR 10141; OR 10163; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL CULTURE; COMPLEX FORMATION; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; IRON CHELATION; LIPID PEROXIDATION; LIVER MICROSOME; MASS SPECTROMETRY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTECTION; PROTEIN DEFECT; RAT; REACTION ANALYSIS;

ASCORBIC ACID; CELL LINE; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA DAMAGE; DNA, SINGLE-STRANDED; EDETIC ACID; GLUCOSE OXIDASE; HYDROGEN PEROXIDE; IRON CHELATING AGENTS; LIPID PEROXIDATION; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROSOMES, LIVER; OXIDATION-REDUCTION; OXIDATIVE STRESS; SPECTROPHOTOMETRY;

EID: 0030060477     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02109-4     Document Type: Article

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