RET oncogene

Current Opinion in Genetics and Development

Volumn 6, Issue 1, 1996, Pages 82-86

  Mak, Yin F ^a   Ponder, Bruce A J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; PROTEIN TYROSINE KINASE;

CARCINOGENESIS; EMBRYO DEVELOPMENT; GENE MUTATION; HIRSCHSPRUNG DISEASE; HUMAN; MULTIPLE ENDOCRINE NEOPLASIA; NEURAL CREST; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; ONCOGENE RET; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; SHORT SURVEY; SIGNAL TRANSDUCTION; THYROID MEDULLARY CARCINOMA;

EID: 0030060096     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(96)90015-5     Document Type: Article

References (16)

1. Takahashi M, Ritz J, Cooper GM: Activation of a novel human transforming gene, ret, by DNA rearrangement Cell 1985, 42:581-588.
2. Takahashi M, Cooper GM: ret transforming gene encodes a fusion protein homologous to tyrosine kineses, Mol Cell Biol 1987, 7:1378-1385.
3. Ishizaka Y, Itoh F, Tahira T, Ikeda I, Sugimura T, Tucker J, Fertitta A, Carrano AV, Nagao M: Human ret proto-oncogene mapped to chromosome 10q11.2. Oncogens 1989, 4:1519-1521.
4. Takahashi M, Buma Y, Iwamoto T, Inaguma Y, Ikeda H, Hiai H: Cloning and expression of the ret proto-oncogene encoding a receptor tyrosine kinase with two potential transmembrane domains. Oncogene 1988, 3:571-578.
5. Takahashi M, Buma Y, Hiai H: Isolation of ret proto-oncogene cDNA with amino-terminal signal. Oncogene 1989, 4:805-806.
6. Pawson T, Schlessinger J: SH2 and SH3 domains. Curr Biol 1993, 3:434-442.
7. Heldin CH: Dimerization of cell surface receptors in signal transduction. Cell 1995, 80:213-223.
8. Schneider R: The human proto-oncogene ret: a communicative cadherin? Trends Biochem Sci 1992 17:468-469.
9. Iwamoto T, Taniguchi M, Asai N, Ohkusu K, Nakashima l, Takahashi M: cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily. Oncogens 1993, 8:1087-1091.
10. Takahashi M, Asai N, Iwashita T, Isomura T, Miyazaki K, Matsuyama M: Characterisation of the ret proto-oncogene products expressed in mouse L cells. Oncogene 1993, 8:2925-2929.
11. Tahira T, Ishizaka Y, Itoh F, Sugimura T, Nagao M: Characterisation of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line. Oncogene 1990, 5:97-102.
12. Myers SM, Eng C, Ponder BAJ, Mulligan LM: Characterisation of RET proto-oncogene 3′ splicing variants and polyadenylation sites: a novel C-terminus for RET. Oncogene 1995, 11:2039-2045.
13. The identification of a novel RET mRNA 3′ splicing variant predicted to encode a third protein isoform of 43 carboxy-terminal amino acids indicates the complexity of RET gene structure.
14. Borrello MG, Pelicci G, Arighi E, De Filippis L, Greco A, Bongarzone I, Rizzetti MG, Pelicci PG, Pierotti MA: The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins. Oncogene 1994, 9:1661-1668.
15. Lorenzo MJ, Eng C, Mulligan LM, Stonehouse TJ, Healey CS, Ponder BAJ, Smith DP: Multiple mRNA isoforms of the human RET proto-oncogene generated by alternate splicing. Oncogene 1995, 10:1377-1383.
16. The authors identify three novel RET mRNA isoforms with distinct 5′ ends. It is predicted that two isoforms are predicted to encode RET proteins with deletions in the extracellular domain whereas the third encodes a soluble, secreted form of the RET receptor.