Stability, blood partition, and protein binding of DA-5018, a new nonnarcotic analgesic

Research Communications in Molecular Pathology and Pharmacology

Volumn 91, Issue 1, 1996, Pages 97-108

  Shim, Hyun J ^a   Lee, Jong J ^a   Lee, Sang D ^a   Kim, Won B ^a   Yang, Junnick ^a   Kim, So H ^b   Lee, Myung G ^b  

^a Dong A Pharmaceutical Company   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN DERIVATIVE; CAPSAVANIL; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL CELL; ARTICLE; DIALYSIS; DOG; DRUG BINDING; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; SPECIES DIFFERENCE;

ANALGESICS, NON-NARCOTIC; ANIMALS; BLOOD CELLS; BLOOD PROTEINS; CAPSAICIN; DOGS; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; OROSOMUCOID; PROTEIN BINDING; RATS; SERUM ALBUMIN; SPECIES SPECIFICITY; TEMPERATURE;

EID: 0030059412     PISSN: 00345164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Goto, S., Yoshitomi, H., Miyamoto, A., Yamada, H., Fuji, S., Nakayama, T. and Fujiwara, K. (1981). Further investigations on the binding of loop diuretics to serum proteins from patients with liver disease. J. Pharmacobiodyn., 4, 865-873.
2. Huang, S.-M. and Chiou, W.L. (1981). Pharmacokinetics and tissue distribution of chlorpheniramine in rabbits after intravenous administration. J. Pharmacokinet. Biopharm., 9, 711-738.
3. Jungbluth, G.L., Pasko, M.T. and Jusko, W.J. (1989). Factors affecting ceftriaxone plasma protein binding during open heart surgery. J. Pharm. Sci., 78, 807-811.
4. Kristensen, C.B. and Gram, L.F. (1982). Equilibrium dialysis for determination of protein binding of imipramine - Evaluation of a method. Acta Pharmacol. Toxicol., 50, 130-136.
5. Lee, H.-J. and Chiou, W.L. (1989). Erythrocytes as barriers for drug elimination in isolated rat liver. II. Propranolol. Pharm. Res., 6, 840-843.
6. Lee, M.G., Chen, M.-L. and Chiou, W.L. (1981). Pharmacokinetics of drugs in blood II: Unusual distribution and storage effect of furosemide. Res. Commun. Chem. Pathol. Pharmacol., 34, 17-23.
7. Lee, S.H. and Lee, M.G. (in press a). Stability, tissue metabolism, tissue distribution, and blood partition of azosemide. Biopharm. Drug Dispos.
8. Lee, S.H. and Lee, M.G. (in press b). Factors influencing the protein binding of azosemide using an equilibrium dialysis technique. Biopharm. Drug Dispos.
9. Lee, W.I., Park, J.H., Yoon, W.H., Lee, J.W., Shim, C.-K. and Lee, M.G. (in press). Factors influencing the protein binding of YH-439 using an equilibrium dialysis technique. A new hepatoprotective agent. Biopharm. Drug Dispos.
10. Mackchan, J.J. (1992). Influence of protein binding and use of unbound (free) drug concentration. In: Applied Pharmacokinetics, Principles of Therapeutics and Drug Monitoring. Third edition. Edited by W.E. Evans, J.J. Schentag, and W.J. Jusko. Applied Therapeutics, Inc. Vancouver, WA pp. 5-1 - 5-48.
11. Øie, S. and Guentert, T.W. (1982). Comparison of equilibrium time in dialysis experiments using spiked plasma of spiked buffer. J. Pharm. Sci., 71, 127-128.
12. Owens, S.M., Mayersohn, M., and Woodworth, J.R. (1983). Phencyclidine blood protein binding: Influence of protein, pH, and species. J. Pharmacol. Exp. Ther., 226, 656-660.
13. Paxton, J.W. (1981). Protein binding of methotrexate in sera from normal human beings; effect of drug concentration, pH, temperature, and storage. J. Pharmacol. Methods, 5, 203-213.
14. Prandota, J. and Pruitt, A.W. (1975). Furosemide binding to human albumin and plasma of nephrotic syndrome. Clin. Pharmacol. Ther., 17, 159-166.
15. Shaw, L.M., Fields, L. and Mayock, R. (1982). Factors influencing theophylne serum protein binding. Clin. Pharmacol. Ther., 32, 490-496.
16. Shim, H.J., Lee, M.G. and Lee, M.H. (1991a). Factors influencing the protein binding of bumetanide using an equilibrium dialysis technique. J. Clin. Pharm. Ther., 16, 467-476.
17. Shin, W.G., Lee, M.G., Lee, M.H. and Kim, N.D. (1991b). Factors influencing the protein binding of vancomycin. Biopharm. Drug Dispos., 12, 637-646.
18. Surh, Y.-J. and Lee, S.S. (1995). Capsaicin, a double-edged sword: Toxicology, metabolism, and chemopreventive potential. Life Sci., 56, 1845-1855.
19. Terao, N. and Shen, D.D. (1983). Alterations in serum protein binding and pharmacokinetics of 1-propranolol in the rat elicited by the presence of an indwelling venous catheter. J. Pharmacol. Exp. Ther., 227, 369-375.