A two-step synthesis of terbinafine

Tetrahedron Letters

Volumn 37, Issue 1, 1996, Pages 57-58

  Alami, Mouâd ^a   Ferri, Fabiola ^a   Gaslain, Yann ^a  

^a ECOLE NORMALE SUPÉRIEURE   (France)

Author keywords

amino enynes; amino vinyl chlorides; palladium; terbinafine

Indexed keywords

TERBINAFINE;

ARTICLE; DRUG SYNTHESIS;

EID: 0030059382     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(95)02095-0     Document Type: Article

References (9)

1. (a) Stütz, A. Angew. Chem. Int. Ed. Engl. 1987, 26, 320-328.
2. (b) Nussbaumer, P.; Leitner, I.; Mraz, K.; Stütz, A. J. Med. Chem. 1995, 38, 1831-1836 and references therein.
3. Rudisill, D.E.; Castonguay, L.A.; Stille, J.K. Tetrahedron Lett. 1988, 29, 1509-1512.
4. The Pd-catalyzed reaction of vinyl iodides with 1-alkynes has also been reported, sec: (a) Genet, J.P.; Blart, E.; Savignac, M. Synlett 1992, 715-717.
5. (b) Alami, M.; Ferri, F.; Linstrumelle, G. Tetrahedron Lett. 1993, 34, 6403-6406 and references therein.
6. Gotteland, J.P.; Halazy, S. Synlett. 1995, 931-932.
7. Alami, M.; Linstrumelle, G. Tetrahedron Lett. 1991, 32, 6109-6112.
8. Van Benthem, R.A.T.M.; Michels, J.J.; Hiemstra, H.; Speckamp, W.W. Synlett. 1994, 368-370.
9. Satisfactory spectral data were obtained for all compounds.