BCL-2 but not its Epstein-Barr virus-encoded homologue, BHRF1, is commonly expressed in posttransplantation lymphoproliferative disorders

Blood

Volumn 87, Issue 2, 1996, Pages 706-711

  Murray, Paul G ^b   Swinnen, Lode J ^b   Constandinou, Christothea M ^b   Pyle, Joseph M ^b   Carr, Thomas J ^b   Hardwick, J Marie ^b   Ambinder, Richard F ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN;

APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; LYMPHOPROLIFERATIVE DISEASE; NONHODGKIN LYMPHOMA; ORGAN TRANSPLANTATION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN INDUCTION; VIRUS CARCINOGENESIS;

EID: 0030058818     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.2.706.bloodjournal872706     Document Type: Article

References (44)

1. Swerdlow SH: Post-transplant lymphoproliferative disorders: A morphologic, phenotypic and genotypic spectrum of disease. Histopathology 20:373, 1992
2. Nalesnik MA, Makowka L, Starzl TE: The diagnosis and treatment of posttransplant lymphoproliferative disorders. Curr Prob Surg 25:367, 1988
3. Aisenberg AC, Wilkes BM, Jacobson JO: The bcl-2 gene is rearranged in many diffuse B-cell lymphomas. Blood 71:969, 1988
4. Ngan B-Y, Chen-Levy Z, Weiss LM, Warnke RA, Cleary ML: Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation. N Engl J Med 318:1638, 1988
5. Henderson S, Rowe M, Gregory C, Croom-Carter D, Wang F, Longnecker R, Kieff E, Rickinson A: Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein I protects infected B cells from programmed cell death. Cell 65:1107, 1991
6. Cleary ML, Smith SD, Sklar J: Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t{14; 18) translocation. Cell 47:19, 1986
7. Henderson S, Huen D, Rowe M, Dawson C, Johnson G, Rickinson A: Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. Proc Natl Acad Sci USA 90:8479, 1993
8. Tarodi B, Subramanian T, Chinnadurai G: Epstein-Barr virus BHRF1 protein protects against cell death induced by DNA damaging agents and heterologous viral infection. Virology 201.404, 1994
9. Swinnen LJ, Costanzo-Nordin MR, Fisher SG, O'Sullivan EJ, Johnson MR, Heroux AL, Dizikes GJ, Pifarre R, Fisher RI: Increased incidence of lymphoproliferative disorder after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients. N Engl J Med 323.1723, 1990
10. Kowal-Vern A, Swinnen LJ, Shankey V, Walloch J, Potocki D, Fisher SG, Molnar Z: Flow and image cytometric DNA analysis of postcardiac transplant lymphomas. Mod Pathol 7:332, 1994
11. Swinnen LJ, Mullen GM, Carr TJ, Costanzo MR, Fisher RI: Aggressive treatment for post-cardiac transplant lymphoproliferation. Blood (in press)
12. Knowles DM, Cesarman E, Chadburn A, Frizzera G, Chen J, Rose EA, Michler RE: Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders. Blood 85:552, 1995
13. National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: Summary and description of working formulation for clinical usage. The Non-Hodgkin's Lymphoma Classification Project. Cancer 49:2112, 1982
14. Ryon JJ, Hayward SD, MacMahon EME, Mann RB, Ling Y, Charache P, Phelan JA, Miller G, Ambinder RF. In situ detection of lytic Epstein-Barr virus infection: Expression of the Notl early gene and vIL-10 late gene in clinical specimens. J Infect Dis 168:345, 1993
15. Ambinder RF, Browning PJ, Lorenzana I, Leventhal BG, Cosenza H, Mann RB, MacMahon EME, Medina R, Cardona V, Grufferman S, Olshan A, Levin A, Petersen EA, Blattner W, Levine PH: Epstein-Barr virus and childhood Hodgkin's disease in Honduras and the United States. Blood 81:461, 1993
16. Cox MA, Leahy J, Hardwick JM: An enhancer within the divergent promoter of Epstein-Barr virus responds synergistically to the R and Z transactivators. J Virol 64:313, 1990
17. Barletta JM, Kingma DW, Ling Y, Charache P, Mann RB, Ambinder RF: Rapid in situ hybridization for the diagnosis of latent Epstein-Barr virus infection. Mol Cell Probes 7:105, 1993
18. Cleary M L, Warnke R, Sklar J: Monoclonality of lympho-proliferative lesions in cardiac-transplant recipients. Clonal analysis based on imunoglobulin-gene rearrangements. N Engl J Med 310:477, 1984
19. Cleary ML, Chao J, Warnke R, Sklar J: Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. Proc Natl Acad Sci USA 81:593, 1984
20. Ambinder R, Mann R: Detection and characterization of Epstein-Barr virus in clinical specimens. Am J Pathol 149:235, 1994
21. Lieberman PM, Hardwick JM, Sample J, Hayward GS, Hayward SD: The Zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-I and ZRE sites in target promoter and enhancer regions. J Virol 64:1143, 1990
22. Bogedain C, Alliger P, Schwarzmann F, Marschall M, Wolf H, Jilg W: Different activation of Epstein-Barr virus immediate-early and early genes in Burkitt lymphoma cells and lymphoblastoid cell lines. J Virol 68:1200, 1994
23. Liebowitz D, Kieff E: Epstein-Barr virus, in Roizman B, Whitley RJ, Lopez C (eds). The Human Herpesviruses. New York, NY, Raven, 1993, p 107
24. Camilleri-Broel S, Davi F, Feuillard J, Bourgeois C, Seihean D, Hauw J-J, Raphael M: High expression of latent membrane protein 1 of Epstein-Barr virus BCL-2 oncoprotein in acquired immunodeficiency syndrome-related primary brain lymphomas. Blood 86:432, 1995
25. Lu QL, Elia G, Lucas S, Thomas JA: Bcl-2 proto-oncogene expression in Epstein-Barr-virus-associated nasopharyngeal carcinoma. Int J Cancer 53:29, 1993
26. Jiwa NM, Kanavaros P, van der Valk P, Walboomers JMM, Horstman A, Vos W, Mullink H, Meijer CJLM: Expression of c-myc and bcl-2 oncogene products in Reed-Sternberg cells independent of presence of EBV. J Clin Pathol 46:211, 1993
27. Kaczorowski S, Kaczorowska M, Christensson B: Expression of EBV encoded latent membrane protein 1 (LMP-1) and bcl-2 protein in childhood and adult Hodgkin's disease; application of mirowave irradiation for antigen retrieval. Leuk Lymphoma 13:273, 1994
28. Claviez A, Tiemann M, Peters J, Kreipe H, Schneppenheim R, Parwaresch R: The impact of EBV, proliferation rate, and BCL-2 expression in Hodgkin's disease in childhood. Ann Hematol 68:61, 1994
29. Khan G, Gupta RK, Coates PJ, Slavin G: Epstein-Barr virus infection and bcl-2 proto-oncogene expression - Separate events in the pathogenesis of Hodgkin's disease? Am J Pathol 143:1270, 1993
30. Armstrong AA, Gallagher A, Krajewski AS: The expression of the EBV latent membrane protein [LMP-I] is independent of CD23 and bcl-2 in Reed-Sternberg cells in Hodgkin's disease. Histopathology 21:72, 1992
31. Schlaifer D, Brousset P, Attal M, Massip P, Payen C, Marehou B, Huguet F, Muller C, Laurent G, Pris J, Delsol G: BCL-2 proto-oncogene and Epstein-Barr virus latent membrane protein-1 expression in AIDS-related lymphoma. Histopathology 25:77, 1994
32. Rowe M, Pengpilon M, Huen DS, Hardy R, Croomcarter D, Lundgren E, Rickinson AB: Upregulation of BCL-2 by the Epstein-Barr virus latent membrane protein LMP1-AB-cell-specific response that is delayed relative to NF-KAPPA-B activation and to induction of cell surface markers. J Virol 68:5602, 1994
33. Nalesnik MA, Starzl TE, Poner KA, Sklar J, Cleary ML: Genolypic analyses of cyclosporine-associated lymphoproliterations. Transplantation 43:592, 1987
34. Locker J, Nalesnik M: Molecular genetic analysis of lymphoid tumors arising after organ transplantalion. Am J Pathol 135:977, 1989
35. Cen H, Williams PA, McWilliams HP, Brienig MC, Ho M. McKnight JLC: Evidence for restricted Epstein-Barr virus latent gene expression and anti-EBNA antibody response in solid organ transplant recipients with post-transplant lymphoproliferative disorders. Blood 81:1393, 1993
36. Rea D, Delecluse HJ, Hamilton-Dutoit SJ, Marelle L, Joab I, Edelman L, Finet JF, Raphael M: Epstein-Barr virus latent and replicative gene expression in post-transplant lymphoprohferative disorders and AIDS-related non-Hodgkin's lymphomas. French Study Group of Pathology for HIV-Associated Tumors. Ann Oncol 5:S113, 1994 (suppl 1)
37. Rea D, Fourcade C, Leblond V, Rowe M, Joab I, Edelman L, Bitker MO, Gandjbakhch I, Suberbielle C, Facet JP, Raphael M: Patterns of Epstein-Barr virus latent and replicative gene expression in Epstein-Barr virus B cell lymphoproliferative disorders after organ transplantation. Transplantation 58:317, 1994
38. Rowe M, Rowe DT, Gregory CD, Young LS, Farrell PJ, Rupani H, Rickinson AB: Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells. EMBO J 6:2743, 1987
39. Patlesen G, Hamilton-Dutoit SJ, Rowe M, Young LS: Expression of Epstein-Barr virus (EBV) latent gene products in tumour cells of Hodgkin's disease. Lancet 337:320, 1991
40. Raab-Traub N: Epstein-Barr virus and nasopharyngeal carcinoma. Cancer Biol 3:297, 1994
41. Deacon EM, Pallesen G, Niedobitek G, Crocker J, Brooks L, Rickinson AB, Young LS: Epistein-Barr virus and Hodgkin's disease: Transcriptional analysis of virus latency in the malignant cells. J Exp Med 177:339, 1993
42. Shibata D, Weiss LM, Hernandez AM, Nathwani BN, Bernstein L, Levine AM: Epstein-Barr virus-associated non-Hodgkin's lymphoma in patients infected with the human immunodeficiency virus. Blood 81:2102, 1993
43. Pallesen G, Hamilton-Dutoit SJ, Rowe M, Lisse I, Ralfkiaer E, Sandvej K, Young L: Expression of Epstein-Barr virus replicative proteins in AIDS-related non-Hodgkin's lymphoma cells. J Pathol 165:289, 1991
44. Grasser FA, Sauder C, Haiss P, Hille A, Konig S, Gottel S, Kremmer E, Leinenbach HP, Zeppezauer M, Muller-Lantzsch N: Immunological detection of proteins associated with the EBV nuclear antigen 2A. Virology 195:550, 1993