Telomere elongation observed in immortalized human fibroblasts by treatment with 60Co gamma rays or 4-nitroquinoline 1-oxide

Human Genetics

Volumn 97, Issue 1, 1996, Pages 1-6

  Sugihara, Shinsuke ^a   Mihara, Koichiro ^a   Marunouchi, Tohru ^b   Inoue, Hajime ^a   Namba, Masayoshi ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; COBALT 60; DNA POLYMERASE;

ARTICLE; CELL DIVISION; CELL IMMORTALIZATION; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; DNA SYNTHESIS; FIBROBLAST; GAMMA RADIATION; HUMAN; HUMAN CELL; MOLECULAR STABILITY; PRIORITY JOURNAL; RESTRICTION FRAGMENT; SENESCENCE; TANDEM REPEAT; TELOMERE;

4-NITROQUINOLINE-1-OXIDE; BASE SEQUENCE; CELL LINE, TRANSFORMED; CLONE CELLS; COBALT RADIOISOTOPES; FETUS; FIBROBLASTS; GAMMA RAYS; HUMANS; LIVER; MALE; MOLECULAR SEQUENCE DATA; REGRESSION ANALYSIS; REPETITIVE SEQUENCES, NUCLEIC ACID; TELOMERE;

EID: 0030058754     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00218823     Document Type: Article

References (31)

1. Agard DA, Sedat JW (1983) Three-dimensional architecture of a polytene nucleus. Nature 302: 676-681
2. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Harley CB (1992) Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89: 10114-10118
3. Bai L, Mihara K, Kondo T, Honma M, Namba M (1993) Immortalization of normal human fibroblasts by treatment with 4-nitroquinoline 1-oxide, Int J Cancer 53: 451-456
4. Blackburn EH (1991) Structure and function of telomeres. Nature 350: 569-573
5. Blackburn EH, Szostak JW (1984) The molecular structure of centromeres and telomeres. Annu Rev Biochem 53: 163-194
6. Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S (1992) Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 11: 1921-1929
7. Counter CM, Hirte HW, Baccheni S, Harley CB (1994a) Telomerase activity in human ovarian carcinoma. Proc Natl Acad Sci USA 91: 2900-2904
8. Counter CM, Botelho FM, Wang P, Harley CB, Bacchetti S (1994b) Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J Virol 68: 3410-3414
9. Harley CB (1991) Telomere loss: mitotic clock or genetic time bomb? Mutat Res 256: 271-282
10. Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460
11. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC (1990) Telomere reduction in human colorectal carcinoma and with ageing. Nature 346: 866-868
12. Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37: 614-636
13. Honma M, Kataoka E, Ohnishi K, Ohno T, Takeuchi M, Nomura N, Mizusawa H (1992) A new DNA profiling system for cell line identification for use in cell banks in Japan. In Vitro Cell Dev Biol 28A: 24-28
14. 50Co gamma rays and the human c-Ha-ras oncogene. In Vitro Cell Dev Biol 29A: 763-767
15. Kano Y, Little JB (1989) Efficient immortalization by SV40 T DNA of skin fibroblasts from patients with Wilms' tumor associated with chromosome 11p deletion. Mol Carcinogenesis 2: 314-321
16. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich SL, Shay JW (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015
17. Kipling D, Cooke HJ (1990) Hypervariabte ultra-long telomeres in mice. Nature 347: 400-402
18. Klingelhutz AJ, Barber SA, Smith PP, Dyer K, McDougall JK (1994) Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells. Mol Cell Biol 14: 961-969
19. Lange T de (1992) Human telomeres are attached to the nuclear matrix. EMBO J 11: 717-724
20. Lange T de, Shiue L, Myers RM, Cox DR, Naylor SL, Killery AM, Varmus HE (1990) Structure and variability of human chromosome ends. Mol Cell Biol 10: 518-527
21. McClintock B (1941) The stability of broken ends of chromosomes in Zea mavs. Genetics 26: 234-282
22. Mehle C, Ljungberg B, Roos G (1994) Telomere shortening in renal cell carcinoma. Cancer Res 54: 236-241
23. 60Co gamma rays. Int J Cancer 50: 639-643
24. Morin GB (1989) The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59: 521-529
25. Nakamura Y, Gillilan S, O'Connell P, Leppert M, Lathrop GM, Lalouel J, White R (1987) Isolation and mapping of a polymorphic DNA sequence pYNH24 on chromosome 2 (D2S44). Nucleic Acids Res 15: 10073
26. 60Co gamma rays. Int J Cancer 35: 275-280
27. Namba M, Nishitani K, Fukushima F, Kimoto T (1988) Multistep carcinogenesis of normal human fibroblasts. Anticancer Research 8: 947-958
28. Olovnikov AM (1973) A theory of marginotomy. J Theor Biol 41: 181-190
29. Smith JK, Yeh G (1992) Telomere reduction in endometrial adenocarcinoma. Am J Obstet Gynecol 167: 1883-1887
30. Shay JW, Wright WE, Brasiskyte D, Van Der Haegen BA (1993) E6 of human papiltomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene 8: 1407-1413
31. Takada T, Hayashi T, Arakawa M, Kominami R (1992) Telomere elongation frequently observed during tumor metastasis. Jpn J Cancer Res 83: 1124-1127