Genetic analysis of glucose regulation in Saccharomyces cerevisiae: Control of transcription versus mRNA turnover

EMBO Journal

Volumn 15, Issue 2, 1996, Pages 363-374

  Cereghino, Geoff P ^a,b   Scheffler, Immo E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HAVERFORD COLLEGE   (United States)

Author keywords

Glucose regulation; Iron protein; mRNA stability; SUC2; Succinate dehydrogenase

Indexed keywords

FUNGAL RNA; GLUCOSE; GLUCOSE REGULATED PROTEIN; MESSENGER RNA; SUCCINATE DEHYDROGENASE;

ARTICLE; CONTROLLED STUDY; ENZYME SUBUNIT; GENE REPRESSION; NONHUMAN; PRIORITY JOURNAL; RNA DEGRADATION; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION;

SACCHAROMYCES CEREVISIAE;

EID: 0030058701     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00366.x     Document Type: Article

References (70)

1. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D D., Smith, J A , Seidman, J.G. and Struhl, K. (1988) Current Protocols in Molecular Biology. John Wiley and Sons, Inc., Media, PA.
2. Beelman, C.A. and Parker, R. (1995) Degradation of mRNA in eukaryotes Cell, 81, 179-183.
3. Benevolensky, S.V., Clifton, D. and Fraenkel, D.G. (1994) The effect of increased phosphoglucose isomerase on glucose metabolism in Saccharomyces cerevisiae. J. Biol. Chem., 269, 4878-4882.
4. Bisson, L F. (1988) High-affinity glucose transport in Saccharomyces cerevisiae is under general glucose repression control. J. Bacteriol., 170, 4838-4845.
5. Bisson, L.F. and Fraenkel, D.G (1983) Involvement of kinases m glucose and fructose uptake by Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA, 80, 1730-1734.
6. Bision, L.F., Coons, D.M., Kruckeberg, A.L. and Lewis (1993) Yeast sugar transporters. Crit. Rev. Biochem. Mol. Biol., 28, 259-308.
7. Carlson, M., Osmond, B.C. and Botstein, D (1981) Mutants of yeast defective m sucrose utilization. Genetics, 98, 25-40.
8. Celenza, J.L. and Carlson, M. (1986) A yeast gene that is essential for release from glucose repression encodes a protein kinase. Science, 233, 1175-1180.
9. Cereghino, G.P., Atencio, D.P., Saghbini, M., Beiner, J. and Scheffler, I.E. (1995) Glucose-dependent turnover of the mRNAs encoding succinate dehydrogenase peptides in Saccharomyces cerevisiae: sequence elements in the 5′ untranslated region of IP mRNA play a dominant role. Mol. Biol. Cell., 6, 1125-1143.
10. Chapman, K.B., Solomon, S.D. and Boeke, J.D. (1992) SDHl, the gene encoding the succinate dehydrogenase flavoprotein subunit from Saccharomyces cerevisiae. Gene, 118, 131-136.
11. Elble, R (1992) A simple and efficient procedure for transformation of yeasts. BioTechniques, 13, 18-20.
12. Entian, K.D., Frohlich, K.U. and Mecke, D (1984) Regulation of enzymes and isozymes of carbohydrate metabolism in the yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta, 799, 181-186.
13. Entian, K D., Hilberg, F., Opitz, H. and Mecke, D. (1985) Cloning of hexokinase structural genes from Saccharomyces cerevisiae mutants with regulatory mutations responsible for glucose repression. Mol. Celt. Biol., 5, 3035-3040.
14. Erickson, J.R. and Johnston, M. (1993) Genetic and molecular characterization of GAL83: its interaction and similarities with other genes involved in glucose repression in Saccharomyces cerevisiae. Genetics, 135, 655-664
15. Erickson, J.R. and Johnston, M. (1994) Suppressors reveal two classes of glucose repression genes in the yeast Saccharomyces cerevisiae. Genetics, 136, 1271-1278
16. Estruch, F. and Carlson, M. (1990) SNF6 encodes a nuclear protein that is required for expression of many genes in Saccharomyces cerevisiae. Mol. Cell. Biol., 10, 2544-2553
17. Estruch, F., Treitel, M.A., Yang, X. and Carlson, M. (1992) N-Terminal mutations modulate yeast SNF1 protein kinase function. Genetics, 132, 639-650.
18. Federoff, H.J , Eccleshall, T.R. and Marmur, J. (1983) Carbon catabolite repression of maltase synthesis in Saccharomyces carlsbergensis. J. Bacteriol., 156, 301-307.
19. Flick, J.S. and Johnston, M. (1991) GKRI of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats. Mol. Cell. Biol., 11, 5101-5112.
20. G-mediated glucose repression of the GAL1 promoter of Saccharomyces cerevisiae. Genetics, 130, 295-304.
21. Fraenkel, D.G. (1992) Genetics and intermediary metabolism. Annu. Rev. Genet., 26, 159-177.
22. Francois, J., Van Schaftingen, E. and Hers, H.-G (1984) The mechanism by which glucose increases fructose 2,6-biphosphate concentration in Saccharomyces cerevisiae. Eur. J. Biochem., 145, 187-193.
23. Hahn, S. and Guarente. L (1988) Yeast HAP2 and HAP3: transcriptional activators in a heteromeric complex. Science, 240, 317-321.
24. Herrick, D., Parker, R and Jacobson, A. (1990) Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae. Mol. Cell Biol , 10, 2269-2284.
25. Hohmann, S. (1993) Characterisation of PDC2, a gene necessary for high level expression of pyruvate decarboxylase structural genes in Saccharomyces cerevisiae. Mol. Gen Genet , 241, 657-666.
26. Holzer, H. (1989) Proteolytic catabolite inactivation in Saccharomyces cerevisiae. Cell Biol. Rev., 21, 283-304.
27. Holzer, H. (1990) The role of fructose 2,6-bisphosphate in yeast. In Pilkis, S.J. (ed), Fructose 2,6-Bisphosphate: The Unique Sugar Diphosphate. CRC Press, Boca Raton, FL, pp. 219-227.
28. Ito, H., Fukuda, Y., Murata, K. and Kimura, A. (1983) Transformation of intact yeast cells treated with alkali cations J. Bacteriol., 153, 163-168.
29. Johnston, M (1987) A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae. Microbiol. Rev., 51, 458-476.
30. Johnston, M. and Carlson, M. (1992) Regulation of carbon and phosphate utilization. In Broach, J., Jones, E W. and Pringle, J. (eds), The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. vol. 2, pp. 192-281.
31. Lang, J M. and Cirillo, V.M. (1987) Glucose transport in a kinase-less Saccharomyces cerevisiae mutant. J. Bacteriol., 169, 2932-2937.
32. Laurent, B.C and Carlson, M. (1992) Yeast SNF2/SWI2, SNF5 and SNF6 proteins function coordinately with the gene-specific transcriptional activators GAL4 and Bicoid. Genes Dev , 6, 1707-1715.
33. Lederer, B., Vissers, S., Van Schaftingen, E. and Hers, H.-G. (1981) Fructose 2,6-bisphosphate in yeast Biochem. Biophys. Res. Commun., 103, 1281-1287.
34. Lobo, Z. and Maitra, P.K. (1977) Resistance to 2-deoxyglucose in yeast: a direct selection of mutants lacking glucose-phosphorylating enzymes. Mol. Gen. Genet., 157, 297-300.
35. Lombardo, A and Scheffler, I.E. (1989) Isolation and characterization of a Saccharomyces cerevisiae mutant with a disrupted gene for the IP subunit of succinate dehydrogenase. J. Biol. Chem., 264, 18874-18877.
36. Lombardo, A., Carine, K. and Scheffler, I.E. (1990) Cloning and characterization of the iron-sulfur subunit gene of succinate dehydrogenase from Saccharomyces cerevisiae. J. Biol. Chem., 265, 10419-10423.
37. Lombardo, A., Cereghino, G.P. and Scheffler, I.E. (1992) Control of mRNA turnover as a mechanism of glucose repression in Saccharomyces cerevisiae. Mol. Cell Biol , 12, 2941-2948
38. Ma, H., Bloom, L.M., Walsh, C.T. and Botstein, D. (1989a) The residual enzymatic phosphorylation activity of hexokinase II mutants is correlated with glucose repression in Saccharomyces cerevisiae. Mol. Cell. Biol., 9, 5643-5649.
39. Ma, H., Bloom, L.M., Zhu, Z , Walsh, C.T. and Botstein, D. (1989b) Isolation and characterization of mutations in the HXK2 gene of Saccharomyces cerevisiae. Mol. Cell. Biol., 9, 5630-5642.
40. Neigeborn, L. and Carlson, M. (1987) Mutations causing constitutive invertase synthesis in yeast: genetic interactions with snf mutations. Genetics, 115, 247-253.
41. Neigeborn, L., Schwartzberg, P., Reid, R. and Carlson, M. (1986) Null mutations in the SNF3 gene of Saccharomyces cerevisiae cause a different phenotype than do previously isolated missense mutations. Mol. Cell. Biol., 6, 3569-3574.
42. Ng, R. and Abelson, J. (1980) Isolation and sequence of the gene for actin in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA, 77, 3912-3916.
43. Niederacher, D. and Entian, K.D. (1991) Characterization of Hex2 protein, a negative regulatory element necessary for glucose repression in yeast. Eur. J. Biochem., 200, 311-319.
44. Nonet, M., Scafe, C., Sexton, J. and Young, R. (1987) Eucaryotic RNA polymerase conditional mutant that rapidly ceases mRNA synthesis. Mol. Cell. Biol., 7, 1602-1611.
45. Olesen, J.T. and Guarente, L. (1990) The HAP2 subunit of yeast CCAAT transcriptional activator contains adjacent domains for subunit association and DNA recognition: model for the HAP2/3/4 complex. Genes Dev., 4, 1714-1729.
46. Olesen, J., Hahn, S. and Guarente, L. (1987) Yeast HAP2 and HAP3 activators both bind to the CYC1 upstrean activation site, UAS2, in an interdependent manner. Cell, 51, 953-961.
47. Özcan, S. and Johnston, M. (1995) Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose. Mol. Cell. Biol., 15, 1564-1572.
48. Özcan, S., Schulte, F., Freidel, K., Weber, A. and Ciriacy, M. (1994) Glucose uptake and metabolism in grr1/cat80 mutants of Saccharomyces cerevisiae. Eur. J. Biochem , 224, 605-611.
49. Peltz, S.W., Brewer, G., Bernstein, P., Hart, P.A. and Ross, J (1991) Regulation of mRNA turnover in eukaryotic cells. Crit. Rev. Eukaryotic Gene Expr , 1, 99-126.
50. Pinkham, J.L and Guarente, L. (1985) Cloning and molecular analysis of the HAF2 locus: a global regulator of respiratory genes in S. cerevisiae. Mol. Cell. Biol., 5, 3410-3416.
51. Ronne, H. (1995) Glucose repression m fungi. Trends Genet., 11, 12-17
52. Rose, M., Albig, W. and Entian, K.D. (1991) Glucose repression in Saccharomyces cerevisiae is directly associated with hexose phosphorylation by hexokinases PI and PII Eur. J. Biochem , 199, 511-518.
53. Schneider, J.C. and Guarente, L. (1991) Regulation of the yeast CYT1 gene encoding cytochrome c by HAP1 and HAP2/3/4. Mol. Cell. Biol., 11, 4934-4942.
54. Sherman, R. Fink, G.R. and Hicks, J.B (1982) Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
55. Sierkstra, L.N., Verbakel, J.M.A. and Verrips, C.T (1992) Analysis of transcription and translation of glycolytic enzymes in glucose-limited continuous cultures of Saccharomyces cerevisiae. J. Gen. Microbiol., 138, 2559-2566.
56. Sierkstra, L.N., Siltjé, H.H.W , Verbakel, J.M.A and Verrips, C.T. (1993) The glucose-6-phosphate-isomerase reaction is essential for normal glucose repression in Saccharomyces cerevisiae. Eur. J. Biochem., 214, 121-127.
57. Surosky, R.T , Strich, R. and Esposito, R.E. (1994) The yeast UME5 gene regulates the stability of meiotic mRNAs m response to glucose Mol. Cell. Biol., 14, 3446-3458.
58. Szekely, E. and Montgomery, D.L. (1984) Glucose represses transcription of Saccharomyces cerevisiae nuclear genes that encode mitochondrial components. Mol. Cell Biol., 4, 939-946.
59. Thevelain, J.M. (1991) Fermentable sugars and intracellular acidification as specific activators of the RAS-adenylate cyclase sinalling pathway in yeast: the relationship to nutrient-induced cell cycle control. Mol. Microbiol., 5, 1301-1307.
60. Trawick, J D , Kraut, N., Simon, F.R. and Poyton, R.O. (1992) Regulation of yeast COX6 by the general transcription factor ABF1 and separate HAP2- and heme-responsive elements. Mol. Cell. Biol., 12, 2302-2314.
61. Trumbly, R.J. (1986) Isolation of Saccharomyces cerevisiae mutants constitutive for invertase synthesis. J. Bacteriol., 166, 1123-1127.
62. Trumbly, R.J. (1988) Cloning and characterization of the CYC8 gene mediating glucose repression in yeast. Gene, 73, 97-111.
63. Trumbly, R.J. (1992) Glucose repression in the yeast Saccharomyces cerevisiae (MicroReview). Mol. Microbiol., 6, 15-21.
64. Ulery, T.L., Jang, S.H. and Jaehning, A. (1994) Glucose repression of yeast mitochondrial transcription: kinetics of derepression and role of nuclear genes. Mol. Cell. Biol., 14, 1160-1170.
65. Vallier, L.G., Coons, D., Bisson, L.F. and Carlson, M. (1994) Altered regulatory responses to glucose are associated with a glucose transport defect in grr1 mutants of Saccharomyces cerevisiae. Genetics, 136, 1279-1285.
66. Williams, F.E. and Trumbly, R.J (1990) Characterization of TUP1, a mediator of glucose repression in Saccharomyces cerevisiae Mol Ceil. Biol., 10, 6500-6511.
67. Williams, F.E., Varanasi, U. and Trumbly, R.J. (1991) The CYC8 and TUP1 proteins involved in glucose repression in Saccharomyces cerevisiae are associated in a protein complex. Mol. Cell. Biol., 11, 3307-3316.
68. Winston, F. and Carlson, M. (1992) Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection. Trends Genet., 8, 387-391.
69. Woods, A., Munday, M.R., Scott, J., Yang, X., Carlson, M. and Carling, D. (1994) Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J. Biol. Chem., 269, 19509-19515.
70. Zimmermann, F.K. and Scheel, I. (1977) Mutants of Saccharomyces cerevisiae resistant to carbon catabolite repression. Mol. Gen. Genet., 154, 75-82.