Synthesis, determination of enantiomeric purity and structural characterisation of enantiopure (2R,5R)-(+)-2,5-bis-(diphenylphosphino)-hexane, a chiral DPPB analogue

Tetrahedron Asymmetry

Volumn 7, Issue 2, 1996, Pages 397-398

  Wiesauer, Christian ^a   Kratky, Christoph ^b   Weissensteiner, Walter ^a  

^a INSTITUT FÜR ORGANISCHE CHEMIE   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 BIS(DIPHENYLPHOSPHINO)HEXANE; ORGANOPHOSPHORUS COMPOUND; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DRUG PURIFICATION; DRUG PURITY; DRUG SYNTHESIS; ENANTIOMER; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; X RAY ANALYSIS;

EID: 0030058555     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/0957-4166(96)00016-X     Document Type: Article

References (12)

1. Brunner, H.; Zettelmeier, W.; Handbook of Enantioselective Catalysis with Transition Metal Compounds, Vol I, II; VCH Publishers, Weinheim, Germany, 1993.
2. Wiesauer, C.; Weissensteiner, W.; Tetrahedron Asymmetry 1995; in press.
3. McKinstry, L.; Livinghouse, T.; Tetrahedron 1995, 51, 7655.
4. a) MacNeil, P. A.; Roberts, N. K.; Bosnich, B.; J. Am. Chem. Soc. 1981, 103, 2273.
5. b) Fryzuk, M. D.; Bosnich, B.; J. Am. Chem. Soc. 1977, 99, 6262.
6. 2) : [λ(Δε)];3 , [230 (-5.5)]; (2S,4S)-Skewphos, [230 (+2.9)].
7. Kyba, E. P.; Rines, S. P. J. Org. Chem. 1982, 47, 4800.
8. 3) : δ= 46.6 ppm; in case of racemic 3 both diastereomers are formed and observed as well resolved singletts (δ=46.6 and 47.1ppm).
9. Kriege-Simondsen, J.; Feltham, R. D.; Inorg. Chim. Acta., 1983, 71, 185.
10. Computer programs used: (a) SHELXTL PC: Version 4.1, Siemens Analytical Instruments, Inc., 1990;
11. (b) SHELXL-93: Sheldrick, G. M.; University of Göttingen, 1993;
12. (c) DIFABS: Walker, N.; Stuart, D.; Acta Crystallogr., 1983, A39, 158.