Bioavailability of meclofenamate from experimental sustained-release microcapsules in beagle dogs

International Journal of Pharmaceutics

Volumn 134, Issue 1-2, 1996, Pages 129-135

  Niazy, Esmail M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Beagle dogs; Bioavailability; Cellulose propionate; Conventional capsules; Mean time parameters; Meclofenamate; Microcapsules; Oral solution; Sustained release

Indexed keywords

CELLULOSE; MACROGOL; MECLOFENAMATE SODIUM; POLYMER;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DISSOLUTION; DOG; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DOSAGE FORM; DRUG RELEASE; EVAPORATION; MALE; MEAN RESIDENCE TIME; MICROCAPSULE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; SUSTAINED RELEASE PREPARATION;

EID: 0030058301     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04343-8     Document Type: Article

References (15)

1. Cutler, D.J., Theory of the mean absorption time, an adjunct to conventional bioavailability studies. J. Pharm. Pharmacol., 30 (1978) 476-478.
2. Deasy, P.B., Microencapsulation and Related Drug Processes, Dekker, New York, 1984.
3. Eberl, R., European studies of sodium meclofenamate (Meclomen®) in long-term treatment. Curr. Ther. Res., 23 (Suppl.) (1978) 131-137.
4. Gibaldi, M. and Perrier, D., Pharmacokinetics, Dekker, New York, 1982.
5. Glazko, A.J., Chang, T., Borondy, P.E., Dill, W.A., Young, R. and Croskey, L., Metabolic disposition of meclofenamic acid (Meclomin®) in laboratory animals and in man. Curr. Ther. Res., 23 (Suppl.) (1978) S22-S41.
6. Koup, J.R., Tucker, E., Thomas, D.J., Kinkel, A.W., Sedman, A.J., Dyer, R. and Sharoky, M., A single and multiple dose pharmacokinetic and metabolism study of meclofenamate sodium. Biopharm. Drug Dispos., 11 (1990) 1-15.
7. Lacey, L.F., Keene, O.N., Duquesnoy, C. and Bye, A., Evaluation of different indirect measures of rate of drug absorption in comparative pharmacokinetics. J. Pharm. Sci., 83 (1994) 212-215.
8. Niazy, E.M., Khidr, S.H. and El-Sayed, Y.M., High-performance liquid chromatographic determination of meclofenamate sodium in plasma. J. Liq. Chromatogr., 17 (1994) 2331-2341.
9. Schall, R. and Luus, H., Comparison of absorption rates in bioequivalence studies of immediate release drug formulations. Int. J. Clin. Pharmacol. Ther. Toxicol., 30 (1992) 153-159.
10. Vargyas, J.M., Campeau, J.D. and Mishell, D.R., Treatment of menorrhagia with meclofenamate sodium. Am. J. Obstet. Gynecol., 157 (1987) 944-950.
11. Ward, J.R., Bolzan, J.A. and Brame, C.L., Sodium meclofenamate (Meclomen®). Dose determining studies. Curr. Ther. Res., 23 (Suppl.) (1978) S60.
12. Willkens, R.F., Experiences in the treatment of osteoarthritis of the hip and knee with sodium meclofenamate (Meclomen®). Curr. Ther. Res., 23 (Suppl.) (1978) 81-89.
13. Willkens, R.F. and Vreed, P., Sodium meclofenamate in the treatment of rheumatoid arthritis: a double-blind comparison with aspirin and placebo. Pharmatherapeutica, 2 (1981) 587-596.
14. Yamaoka, K., Nakagawa, T. and Uno, T., Statistical moments in pharmacokinetics. J. Pharmacokinet. Biopharm., 6 (1978) 547-558.
15. Zuckner, J., Baldossare, A. and Harris, G.S., Sodium meclofenamate (vs placebo) in the treatment of rheumatic arthritis. Curr. Ther. Res., 23 (Suppl.) (1978) S66-S71.