Dissociation of hypothalamic NPY from BAT uncoupling protein mRNA in rats exposed to 24 h thermoneutrality

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 270, Issue 1 39-1, 1996, Pages

  Bing, Chen ^b   Frankish, Helen ^b   Wang, Qiong ^b   Hopkins, David ^b   Keith, Jacqueline ^b   Trayhurn, Paul ^b   Williams, Gareth ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b NONE

Author keywords

brown adipose tissue; energy balance; hypothalamus; neuropeptide Y; thermogenesis

Indexed keywords

NEUROPEPTIDE Y; UNCOUPLING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RNA SYNTHESIS; THERMOGENESIS;

EID: 0030058264     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1996.270.1.r111     Document Type: Article

References (32)

1. Arase, K., D. A. York, H. Shimizu, N. Shargill, and G. A. Bray. Effects of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats. Am. J. Physiol. 255 (Endocrinol. Metab. 18): E255-E259, 1988.
2. Bai, F. L., M. Yamano, Y. Shiotani, P. C. Emson, A. D. Smith, J. F. Powell, and M. Tohyama. An arcuate-paraventricular and -dorsomedial hypothalamic neuropeptide Y containing system which lacks noradrenaline in the rat. Brain. Res. 331: 172-175, 1985.
3. Billington, J., J. E. Briggs, M. Grace, and A. S. Levine. Effect of intracerebroventricular injection of neuropeptide Y on energy metabolism. Am. J. Physiol. 260 (Regulatory Integrative Comp. Physiol. 29): R321-R327, 1991.
4. Billington, C. J., J. E. Briggs, H. M. Grace, and A. S. Levine. Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R1765-R1770, 1994.
5. Bing, C., H. M. Frankish, Q. Wang, P. Trayhurn, and G. Williams. Acute cold exposure increases neuropeptide Y receptor density in the rat hypothalamus. Clin. Sci. Lond. 87: 30p, 1994.
6. Brady, L. S., M. A. Smith, P. W. Gold, and M. Herkenham. Altered expression of hypothalamic neuropeptide Y mRNAs in food-restricted and food-deprived rats. Neuroendocrinology 52: 441-447, 1990.
7. Brander, F., J. S. Keith, and P. Trayhurn. A 27-mer oligonucleotide probe for the detection and measurement of the mRNA for uncoupling protein in brown adipose tissue of different species. Comp. Biochem. Physiol. B Comp. Biochem. 104B: 125-131, 1992.
8. Brown, D., G. Livesey, and M. J. Dauncey. Influence of mild cold on the components of 24 h thermogenesis in rats. J. Physiol. Lond. 441: 137-154, 1991.
9. Champigny, O., and D. Ricquier. Effects of fasting and refeeding on the level of uncoupling protein messenger RNA in rat brown adipose tissue - evidence for diet-induced and cold-induced responses. J. Nutr. 120: 1730-1736, 1990.
10. Egawa, M., H. Yoshimatsu, and G. A. Bray. Neuropeptide Y suppresses sympathetic activity to intrascapular brown adipose tissue in rats. Am. J. Physiol. 260 (Regulatory Integrative Comp. Physiol 29): R328-R334, 1991.
11. Frankish, H. M., D. H. McCarthy, S. Dryden., A. Kilpatrick, and G. Williams. Neuropeptide Y receptor numbers are reduced in the hypothalamus of streptozotocin-diabetic and food-deprived rats: further evidence of increased activity of hypothalamic NPY-containing pathways. Peptides NY 14: 941-948, 1993
12. Giraudo, S. Q., C. M. Kotz, M. K. Grace, A. S. Levine, and C. J. Billington. Rat hypothalamic NPY mRNA and brown fat uncoupling protein mRNA after high-carbohydrate or high-fat diets Am. J Physiol. 266 (Regulatory Integratire Comp. Physiol. 35): R1578-R1583, 1994
13. Gray, T. S., and J. E. Morley. Neuropeptide Y; anatomical distribution and possible function in mammalian nervous system. Life. Sci. 38: 389-401, 1986.
14. Jones, P. M., A. M. Pierson, G. Williams, M. A. Ghatei, and S. R. Bloom. Increased hypothalamic neuropeptide Y messenger RNA in two rat models of diabetes. Diabetic Med. 9: 76-80, 1992.
15. Kalra, S. P., M. G. Dube, A. Sahu, C. Phelps, and P. S. Kalra. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl Acad. Sci USA 88: 10931-10935, 1991.
16. Lewis, D., L. Shellard, D. G. Koeslag, D. E. Boer, H. D. McCarthy, P. E. McKibbin, J. C. Russell, and G. Williams. Intense physical exercise and food restriction cause similar increases in hypothalamic neuropeptide Y concentrations in rats. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E279-E284, 1993.
17. McCarthy, H. D., A. P. Kilpatrick, P. Trayhurn, and G. Williams. Widespread increases in regional hypothalamic neuropeptide Y levels in acute cold-exposed rats. Neuroscience 54: 127-132, 1993.
18. Morley, J. E. Neuropeptide regulation of appetite and weight. Endocrinol. Rev. 8: 256-287, 1987.
19. Morley, J. E., A. S. Levine, B. A. Gosnell, J. Kneip, and M. Grace. Effect of neuropeptide Y on ingestive behaviors in the rat. Am. J. Physiol. 252 (Regulatory Integrative Comp. Physiol 21): R599-R609, 1987.
20. Nicholls, D. G., and R. M. Locke. Thermogenic mechanisms in brown fat. Physiol Rev. 64: 1-64, 1984.
21. Ohno, H., H. Yamashita, N. Sato, Y. Habara, S. Gasa, J. Nagasawa, Y. Sato, M. Ishikawa, M. Segawa, and M. Yamamoto. Interaction between heat acclimation and exogenous insulin in brown adipose tissue of rats. Int. J. Biometeorol. 36: 155-158, 1992.
22. Smith, M. S. Lactation alters neuropeptide-Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat. Endocrinology 133: 1258-1265, 1993.
23. Ricquier, D., L. Casteilla, and F. Bouillaud. Molecular studies of the uncoupling protein. FASEB J. 5: 2237-2242, 1991
24. Rogers, P., P. E. McKibbin, and G. Williams. Acute fenfluramine administration reduces neuropeptide Y concentrations in specific hypothalamic regions of the rat: possible implications for anorectic effects of fenfluramine. Peptides NY 12: 251-255, 1990.
25. Sahu, A., P. S. Kalra, and S. P. Kalre. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides NY 9: 83-86, 1988.
26. Stanley, B. G., D. R. Daniel, A. S. Chin, and S. F. Leibowitz. Paraventricular nucleus injections of peptide YY and neuropep-tide Y preferentially enhance carbohydrate ingestion. Peptides NY 6. 1205-1211, 1985.
27. Stanley, B. G., S. E. Kyrkouli, S. Lampert, and S. F. Leibowitz. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides NY 7: 1189-1192, 1986.
28. Trayhurn, P. Brown adipose tissue: from thermal physiology to bioenergetics. J. Biosci. 18: 161-173, 1993.
29. Trayhurn, P., M. Ashwell, G. Jennings, D. Richard, and D. M. Stirling. Effect of warm or cold exposure on GDP binding and uncoupling protein in rat brown fat. Am. J. Physiol. 252 (Endocrinol. Metab. 15): E237-E243, 1987.
30. Trayhurn, P., and J. S. Duncan. Rapid chemiluminescent detection of the mRNA for uncoupling protein in brown adipose tissue by Northern hybridization with a 32-mer oligonucleotide end-labelled with digoxigenin. Int. J. Obesity 18: 449-452, 1994.
31. White, J. D., D. Olchovsky, M. Kershaw, and M. Berlowitz. Increased hypothalamic content of preproneuropeptide Y messenger RNA in streptozotocin-diabetic rats. Endocrinology 126: 765-772, 1990.
32. Williams, G., J. S. Gill, Y. C. Lee, H. M. Cardoso, B. E. Okpere, and S. Bloom. Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozocin-induced diabetic rats. Diabetes 38: 3321-3327, 1989.