Tumor-specific expression and alternate splicing of messenger ribonucleic acid encoding activin/transforming growth factor-β receptors in human pituitary adenomas

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 2, 1996, Pages 783-790

  Alexander, Joseph M ^a   Bikkal, Helen A ^c   Zervas, Nicholas T ^a   Laws Jr , Edward R ^b   Klibanski, Anne ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c Massachusetts General Hospital ^*

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; MESSENGER RNA; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; HYPOPHYSIS CELL; HYPOPHYSIS TUMOR; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ACTIVIN RECEPTORS; ACTIVINS; ADENOMA; ADOLESCENT; ADULT; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; BASE SEQUENCE; GENE EXPRESSION; HUMANS; INHIBINS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PITUITARY NEOPLASMS; POLYMERASE CHAIN REACTION; RECEPTORS, GROWTH FACTOR; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

EID: 0030058085     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.2.783     Document Type: Article

References (40)

1. Mathews LS. 1994 Activin receptors and cellular signaling by the receptor serine kinase family. [Review]. Endocr Rev. 15:310-325.
2. Billestrup N, Gonzalez-Manchon C, Potter E, Vale W. 1990 Inhibition of somatotroph growth and growth hormone biosynthesis by activin in vitro. Mol Endocrinol. 4:356-362.
3. Bilezikjian LM, Blount AL, Campen CA, Gonzalez-Manchon C, Vale W. 1991 Activin-A inhibits proopiomelanocortin messenger RNA accumulation and adrenocorticotropin secretion of AtT20 cells. Mol Endocrinol. 5:1389-1395.
4. Alexander JM, Biller BM, Bikkal H, Zervas NT, Arnold A, Klibanski A. 1990 Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Clin Invest. 86:336-340.
5. Gicquel C, Le Bouc Y, Luton JP, Girard F, Bertagna X. 1992 Monoclonality of corticotroph macroadenomas in Cushing's disease. J Clin Endocrinol Metab. 75:472-475.
6. Herman V, Fagin J, Gonsky R, Kovacs K, Melmed S. 1990 Clonal origin of pituitary adenomas. J Clin Endocrinol Metab. 71:1427-1433.
7. Alexander JM, Jameson JL, Bikkal HA, Schwall RH, Klibanski A. 1991 The effects of activin on follicle-stimulating hormone secretion and biosynthesis in human glycoprotein hormone-producing pituitary adenomas. J Clin Endocrinol Metab. 72:1261-1267.
8. Alexander JM, Swearingen B, Tindall GT, Klibanski A. 1995 Human pituitary adenomas express endogenous inhibin subunit and follistatin messenger ribonucleic acids. J Clin Endocrinol Metab. 80:147-152.
9. Haddad G, Penabad JL, Bashey HM, et al. 1994 Expression of activin/inhibin subunit messenger ribonucleic acids by gonadotroph adenomas. J Clin Endocrinol Metab. 79:1399-1403.
10. Miller GM, Alexander JM, Bikkal HA, Katznelson L, Zervas NT, Klibanski A. 1995 Somatostatin receptor subtype gene expression In pituitary adenomas. J Clin Endocrinol Metab. 80:1386-1392.
11. Greenman Y, Melmed S. 1994 Heterogeneous expression of two somatostatin receptor subtypes in pituitary tumors. J Clin Endocrinol Metab. 78:398-403.
12. Alexander JM, Klibanski A. 1994 Gonadotropin-releasing hormone receptor mRNA expression by human pituitary tumors in vitro. J Clin Invest. 93:2332-2339.
13. Kadin ME, Cavaille-Coll MW, Gertz R, Massague J, Cheifetz S, George D. 1994 Loss of receptors for transforming growth factor beta in human T-cell malignancies. Proc Natl Acad Sci USA. 91:6002-6006.
14. Park K, Kim SJ, Bang YJ, et al. 1994 Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta. Proc Natl Acad Sci USA. 91:8772-8776.
15. Wrana JL, Attisano L, Wieser R, Ventura F, Massague J. 1994 Mechanism of activation of the TGF-beta receptor. Nature. 370:341-347.
16. Hanks SK, Quinn AM, Hunter T. 1988 The protein kinase family: conserved features and deduced phylogeny of the catalytic domains [Review]. Science. 241:42-52.
17. Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF. 1992 Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/ threonine kinase [published erratum appears in Cell 1992 Sep 18;70(6):following 1068]. Cell. 68:775-785.
18. Xu J, Matsuzaki K, McKeehan K, Wang F, Kan M, McKeehan WL. 1994 Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition. Proc Natl Acad Sci USA. 91:7957-7961.
19. Chomczynski P, Sacchi N. 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162: 156-159.
20. Bassing CH, Howe DJ, Segarini PR, Donahoe PK, Wang XF. 1994 A single heteromeric receptor complex is sufficient to mediate biological effects of transforming growth factor-beta ligands. J Biol Chem. 269:14861-14864.
21. Attisano L, Carcamo J, Ventura F, Weis FM, Massague J, Wrana JL. 1993 Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. Cell. 75:671-680.
22. Carcamo J, Weis FM, Ventura F, et al. 1994 Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. Mol Cell Biol. 14:3810-3821.
23. ten Dijke P, Yamashita H, Ichijo H, et al. 1994 Characterization of type I receptors for transforming growth factor-beta and activin. Science. 264:101-104.
24. Wieser R, Attisano L, Wrana JL, Massague J. 1993 Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region. Mol Cell Biol. 13:7239-7247.
25. ten Dijke P, Ichijo H, Franzen P, et al. 1993 Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene. 8:2879-2887.
26. Koenig BB, Cook JS, Wolsing DH, et al. 1994 Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Mol Cell Biol. 14: 5961-5974.
27. ten Dijke P, Yamashita H, Sampath TK, et al. 1994 Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem. 269:16985-16988.
28. Attisano L, Wrana JL, Cheifetz S, Massague J. 1992 Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/ threonine kinase receptors. Cell. 68:97-108.
29. Chen RH, Derynck R. 1994 Homomeric interactions between type II transforming growth factor-beta receptors. J Biol Chem. 269:22868-22874.
30. Mathews LS, Vale WW. 1991 Characterization of type II activin receptors. Binding, processing, and phosphorylation. J Biol Chem. 268:19013-19018.
31. Mathews LS, Vale WW. 1991 Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell. 65:973-982.
32. Hilden K, Tuuri T, Eramaa M, Ritvos O. 1994 Expression of type II activin receptor genes during differentiation of human K562 cells and cDN A cloning of the human type IIB activin receptor. Blood. 83:2163-2170.
33. Cameron VA, Nishimura E, Mathews LS, Lewis KA, Sawchenko PE, Vale WW. 1994 Hybridization histochemical localization of activin receptor subtypes in rat brain, pituitary, ovary, and testis. Endocrinology. 134:799-808.
34. Bassing CH, Yingling JM, Howe DJ, et al. 1994 A transforming growth factor beta type I receptor that signals to activate gene expression. Science. 263:87-89.
35. Hemmati-Brivanlou A, Melton DA. 1992 A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos [see comments]. Nature. 359:609-614.
36. Shi E, Kan M, Xu J, Wang F, Hou J, McKeehan WL. 1993 Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants. Mol Cell Biol. 13:3907-3918.
37. Hou JZ, Kan MK, McKeehan K, McBride G, Adams P, McKeehan WL. 1991 Fibroblast growth factor receptors from liver vary in three structural domains. Science. 251:665-668.
38. Ewen M, Sluss H, Whitehouse L, Livingstone D. 1993 Cdk4 modulation by TGF-B leads to cell cycle arrest. Cell. 74:1009-1020.
39. Polyak K, Kato JY, Solomon MJ, et al. 1994 p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 8:9-22.
40. Hannon GJ, Beach D. 1994 p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest [see comments]. Nature. 371:257-261.