The influence of alkoxymethyl purine and pyrimidine acyclonucleosides on growth inhibition of Kirkman-Robbins hepatoma and possible mechanism of their cytostatic activity

Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Volumn 51, Issue 1-2, 1996, Pages 75-80

  Modrzejewska, Hanna ^a   Greger, Janusz ^a   Dramiñski, Marcin ^a   Rutkowski, Maciej ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Acyclonucleosides; Allyloxymethyl Purine and Pyrimidine; Deoxynucleoside Kinases; Hepatoma

Indexed keywords

ANTINEOPLASTIC AGENT; DEOXYGUANOSINE KINASE; PHOSPHOTRANSFERASE; PURINE NUCLEOSIDE; PYRIMIDINE NUCLEOSIDE; THYMIDINE KINASE;

ANIMAL; ARTICLE; BIOTRANSFORMATION; CELL DIVISION; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; FEMALE; HAMSTER; KINETICS; LIVER TUMOR; METABOLISM; PATHOLOGY; PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; SYRIAN HAMSTER; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOTRANSFORMATION; CELL DIVISION; CRICETINAE; FEMALE; KINETICS; LIVER NEOPLASMS; LIVER NEOPLASMS, EXPERIMENTAL; MESOCRICETUS; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PURINE NUCLEOSIDES; PYRIMIDINE NUCLEOSIDES; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE KINASE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0030057920     PISSN: 09395075     EISSN: None     Source Type: Journal    
DOI: 10.1515/znc-1996-1-214     Document Type: Article

References (19)

1. Balzarini J., Bohman C., Walker R.T. and De Clerq E. (1994). Comparative cytostatic activity of different antiherpes drugs against herpes simplex virus thymidine kinase gene transfected tumor cells. Molec. Pharmacol. 45, 1253-1258.
2. Bradford M. (1976), A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein - dye binding. Anal. Biochem. 72, 248-254.
3. Browska A., Ananiev A.V., Ramzaeva N., Alksins E., Maurins A., Kulikowska E. and Shugar D. (1994). Purine nucleoside phosphorylase: inhibition by purine N (7) and N (9) acyclonucleosides and substrate properties of 7-β-D-ribofuranosylguanine and 7-β-D-ribofuranosylhypoxandine. Biochem. Pharmacol. 48, 937-947.
4. Drabikowska A.K., Lissowska L., Dramiñski M., Zgit-Wróblewska A. And Shugar D. (1987), Acyclonucleoside analogues consisting of 5 and 5,6 substituted uracil and different acyclic chains: inhibitory properties versus E.coli uridine phosphorylase. Z. Naturforsch. 42c, 288-296.
5. Fossey C., Laduree D. and Robba M. (1994), Synthesis of acyclic thieno (3,2-d) pyrimidine nucleosides and azido derivatives as potential anti HIV agents. Nucleosides & Nucleotides 13, 883-889.
6. Goudgaon N.M., McMillan A. and Schinazi R.F. (1992), 1-(Ethoxymethyl)-6-(phenyl selenenyl) pyrimidines with activity against human immunodeficiency virus types 1 and 2. Antiviral Chem. & Chemother. 3, 20-265.
7. Greger J. and Dramiñski M. (1989). Growth inhibition of Kirkman-Robbins hepatoma by 1(1',3'-dihydroxy2-propoxymethyl)5,6 tertramethyleneuracil and possible mechanism of its biological activity. Z. Naturforsch. 44c, 985-991.
8. Hayashi S., Phadtare S., Zemlicka J., Matusakura M., Mitsuya H. and Broder S. (1988), Adenallene and cytallene: acyclic nucleoside analogues that inhibit replication and cytopathic effect of human immunodeficiency virus in vitro. Proc. Natl. Acad. Sci. USA 85, 6127-6131.
9. Jarvi E.T., McCarthy J.R., Mehdi S., Matthews D.P., Edwards M.L., Prakash N.J., Bowlin T.L., Sunkara P.S. and Bey P. (1991). 4',5' unsaturated 5 halogenated nucleosides. Mechanism-based and competitive inhibitors of S-adenosyl-L-homocysteine hydrolase. J. Med. Chem. 34, 647-656.
10. Krenitsky T.A., Tuttle J.V., Miller W.H., Moorman A.R., Orr G.F. and Beauchamp L. (1990), Nucleotide analogue inhibitors of purine nucleoside phosphorylase. J. Biol. Chem. 265, 3066-3069.
11. Modrzejewska H., Greger J., Lewandowska U. and Fidek W. (1994), In vivo phosphorylation of allyloxymethyl purine and pyrimidine acyclonucleosides and the inhibitory effect of these compounds on thymidine and deoxyguanosine kinases. Acta Biochim. Polon. 41, 185-187.
12. Naguib F.N.M., Levesque D.L., Wang E.C., Panzica R.P. and El Kouni M.H. (1993), 5-Benzylbarbituric acid derivatives, potent and specific inhibitors of uridine phosphorylase. Biochem. Pharmacol. 46, 1273-1283.
13. Neyts J. and De Clerq E. (1994). Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. Biochem. Pharmacol. 47, 39-41.
14. Ozierov A.A., Novkov M.C., Brel A.K., Andrejeva O.T., Vladyko G.V., Boreko E.I., Korbachenko L.V. and Vervetchenko C.G. (1991), The systhesis and antiviral activity of newly synthesized unsaturated pyrimidine acyclonucleosides. Chim. Pharm. 25, 44-47.
15. Rutkowski M. and Dramiñski M. (1991), Phosphorylation of acyclonucleosides by nucleoside phosphotranferase from higher plants and bacteria. Acta Biochim Polon. 38, 449-457.
16. Sakamoto S., Ebuchi M. and Iwama T. (1993), Relative activities of thymidylate synthetase and thymidine kinase in human mammary tumors. Anticancer Res. 13, 205-207.
17. Starzyk H., Rzucidlo Z., Djaczenko W. and Granska J. (1969), Some morphologic, biologic and metabolic properties of transplantable Kirkman-Ribbins hepatoma in hamsters. Arch. Immunol. Ther. Experimental. 17, 523-535.
18. Tanaka H., Baba M., Takahashi E., Matsumoto K., Kittaka A., Walker R.T. and De Clerq E. (1994). Design and synthesis of regioisomeric analogues of a specific anti-HIV-1 agent 1[(2 hydroxyethoxy) methyl]-6-(phenylthio) thymine (HEPT). Nucleosides & Nucleotides 13, 155-162.
19. Wang E.C., Chen H.Y. and Tzega C.L. (1994), Acyclic nucleosides synthesis of 1[(hydroxy-2-propoxy) methyl] thymine, 6-azathymine, uracil and 6-azauracil as potential antiviral agents. Nucleosides & Nucleotides 13, 1201-1213.