Induction of apoptosis by cordycepin in ADA-inhibited TdT-positive leukemia cells

Leukemia

Volumn 10, Issue 6, 1996, Pages 1019-1024

  Koc Y ^a   Urbano, A G ^a   Sweeney, E B ^a   McCaffrey, R ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

3' deoxyadenosine; Coformycin; Cordycepin; Deoxycoformycin; Purine analogues; TdT

Indexed keywords

ADENOSINE DEAMINASE; CORDYCEPIN; CORDYCEPIN DERIVATIVE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA; DNA NUCLEOTIDYLEXOTRANSFERASE; ENDONUCLEASE; PLASMID DNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VOLUME; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA DEGRADATION; DNA SUPERCOILING; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MEMBRANE STRUCTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0030057427     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Beabealashvilli RS, Scamrov AV, Kutateladze TV, Mazo AM, Krayevsky AA, Kukhanova MH. Nucleoside 5′ triphosphates modified at sugar residues as substrates for calf thymus terinal deoxynucleotidyl transferase and for AMV reverse transcriptase. Biochem Biophys Acta 1986; 868: 136-144.
2. Sanger F, Niclen S, Coulson AR. DNA sequencing with chain terminating inhibitors. Proc Natl Acad Sci 1977; 74: 5463-5467.
3. Duff R, Bulger K, Flora C, Poplack D, Schinazi R, Chu CK, McCaffrey R. TdT substrate analogues; structure-function studies with dideoxyadenosine. Blood 1989; 74: (Suppl. 1): 78a.
4. Koç Y, Chu CK, Beardsley GP, McCaffrey RP. Cordycepin is selectively cytotoxic for TdT-positive cells. Blood 1992; 80 (Suppl. 1): 451a.
5. Koç Y, McCaffrey R. 2′, 3′-dideoxyadenosine killing of TdT-positive cells is due to a trace contaminant. Leukemia 1995; 9: 53-57.
6. Spigelman Z, Duff R, Beardsley GP, Broder S, Cooney D, Landau NR, Mitsuya H, Buddy Ullman B, McCaffrey R. 2′,3′-dideoxyadenosine is selectively toxic for TdT-positive cells. Blood 1988; 71: 1601-1608.
7. McCaffrey RP, Harrison TA, Parkman R, Baltimore D. Terminal deoxynucleotidyl transferase activity in human leukemia cells and in normal human thymocytes. New Engl J Med 1975; 292: 775-780.
8. Hansen MB, Nielsen SE, Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Meth 1989; 119: 203-210.
9. Miyamoto E, Kuo JF, Greengard P. Cyclic nucleotide-dependent protein kinases. J Biol Chem 1969; 244: 6395-6402.
10. Frandsen EK, Kirshna G. A simple ultrasensitive method for the assay of cyclic AMP and cyclic CMP in tissues. Life Sci 1976; 18: 529-541.
11. McConkey DJ, Orrenius S, Jondal M. Cellular signalling in programmed cell death (apoptosis). Immunol Today 1990; 11: 120-121.
12. McConkey DJ, Orrenius S, Jondal M. Agents that elevate cAMP stimulate DNA fragmentation in thymocytes. J Immunol 1990; 145: 1227-1230.
13. McConkey DJ, Hartzell P, Jondal M, Orrenius S. Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C. J Biol Chem 1989; 264: 13399-13402.
14. Deibel MR. A specific endonuclease which co-purifies with calf thymus terminal deoxynucleotidyl transferase. Biochem Biophys Res Commun 1983; 115: 909-916.
15. Peitsch MC, Polzar B, Stephan H, Crompton T, MacDonald HR, Mannherz HC, Tschopp J. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J 1993; 12: 371-377.
16. Barry MA, Eastman A. Identification of deoxyribonuclease II as an endonuclease involved in apoptosis. Arch Biochem Biophys 1993; 300: 440-450.
17. Montague JW, Gaido ML, Frye C, Cidlowski JA. A calcium-dependent nuclease from apoptotic rat thymocytes is homologous with cyclophilin. Recombinant cyclophilins A, B, and C have nuclease activity. J Biol Chem 1994; 269: 18877-18880.
18. Ribeiro JM, Carson DA. Ca2+/Mg(2+)-dependent endonuclease from human spleen: purification, properties and role in apoptosis. Biochemistry 1993; 32: 9129-9136.
19. Stewart BW. Mechanism of apoptosis: integration of genetic, biochemical, and cellular indicators. J Natl Cancer Inst 1994; 86: 1286-1296.
20. Compton MM, Cidlowski JA. Identification of a glucocorticoid-induced nuclease in thymocytes. A potential lysis gene product. J Biol Chem 1987; 262: 8288-8292.
21. Gaido ML, Cidlowski JA. Identification, purification and characterization of a calcium-dependent endonuclease (NUC 18) from apoptotic rat thymocytes. NUC 18 is not histone H2B. J Biol Chem 1991; 266: 18580-18585.
22. Machaca K, Compton MM. Characterization of apoptosis-like endonuclease activity in avian thymocytes. Biol Cell 1993; 76: 15-22.
23. Nikonova LV, Beltsky IP, Umansky SR. Properties of some nuclear nucleases of rat thymocytes and their changes in radiation-induced apoptosis. Eur J Biochem 1993; 215: 893-901.
24. Alt FW, Baltimore D. Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci USA 1982; 79: 4118-4122.
25. Gilfillan S, Dierich A, Lemeur M, Bernoist C, Mathis D. Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science 1993; 261: 1175-1178.
26. Komori T, Okada A, Stewart V, Alt FW. Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science 1993; 261: 1171-1174.