Growth hormone neuropathology in Down syndrome (trisomy 21)

Developmental Brain Dysfunction

Volumn 9, Issue 2-3, 1996, Pages 100-113

  Wisniewski, K E ^a,b   Castells, S ^a,b   Mandys, V ^c  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

Author keywords

Brain abnormalities; Chick dorsal root ganglia; Down syndrome; Growth hormone; Nerve growth factor; Neuropathology of Down syndrome; Short term organ culture

Indexed keywords

GROWTH HORMONE; NERVE GROWTH FACTOR; THYROXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CHICKEN; DOWN SYNDROME; GROWTH HORMONE DEFICIENCY; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; MICROCEPHALY; NONHUMAN; RAT; REVIEW;

EID: 0030057246     PISSN: 10195815     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (67)

1. Bondy CA, Werner H, Roberts CT Jr, Le Roith D: Cellular pattern of insulin-like growth factor-I (IGF-I) and type 1 IGF receptor gene expression in early organogenesis: Comparison with IGF-II gene expression. Mol Endocrinol 1990;4:1386-1398.
2. Roghani M, Lassarre C, Zapf J, Povoa G, Binoux M: Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins. J Clin Endocrinol Metab 1991;73:658-666.
3. Wood TL, Brown AL, Rechler MM, Pintar JE: The expression pattern of an insulin-like growth factor (IGF)-binding protein gene is distinct from IGF-II in the midgestational rat embryo. Mol Endocrinol 1990;4:1257-1263.
4. Lamson G, Pham H, Oh Y, Ocrant I, Schwander J, Rosenfeld RG: Expression of the BRL-3A insulin-like growth factor binding protein (rBP-30) in the rat central nervous system. Endocrinology 1989;125:1100-1102.
5. Roth RA, Steele-Perkins G, Hari J, Stover C, Pierce S, Turner J, Edman JC, Rutter WJ: Insulin and insulin-like growth factor receptors and responses. Cold Spring Harbor Symp Quant Biol 1988;53:537-543.
6. Sara VR, Hall K, Misaki M, Fryklund L, Christensen N, Wetterberg L: Ontogenesis of somatomedin and insulin receptors in the human fetus. J Clin Invest 1983;71:1084-1094.
7. Werther GA, Abate M, Hogg A, Cheesman H, Oldfield B, Hards D, Hudson P, Power B, Freed K, Herington AC: Localization of insulin-like growth factor-I mRNA in rat brain by in situ hybridization-relationship to IGF-I receptors. Mol Endocrinol 1990;4:773-778.
8. Valentino KL, Ocrant I, Rosenfeld RG: Developmental expression of insulin-like growth factor-II receptor immunoreactivity in the rat central nervous system. Endocrinology 1990;126:914-920.
9. Schmidt-Sidor B, Wisniewski KE, Shepard TH, Sersen EA: Brain growth in Down syndrome subjects ages: 15 to 22 weeks of gestational age and birth to 60 months. Clin Neuropathol 1990;9:181-190.
10. Wisniewski KE, Kida E: Abnormal neurogenesis and synaptogenesis in Down syndrome brain. Dev Brain Dysfunct, in press.
11. Golden JA, Hyman BT: Development of the superior temporal neocortex is anomalous in trisomy 21. J Neuropathol Exp Neurol 1994;53:513-520.
12. Palmer CGS, Cronk C, Pueschel SM, Wisniewski KE, Laxova R, Crocker AC, Pauli RM: Head circumference of children with Down syndrome (0-36 months). Am J Med Genet 1992;42:61-67.
13. Benda CE: Down's syndrome: Mongolism and its management, revised. New York, Grune & Stratton, 1969.
14. Courchesne E: Physioanatomical considerations in Down syndrome; in Nadel L (ed): The Psychobiology of Down syndrome. Cambridge, MIT Press, 1988, pp 291-313.
15. Crome L, Cowie V, Slater E: A statistical note on cerebellar and brain-stem weight in mongolism. J Ment Defic Res 1966;10:69-72.
16. Jacob H: Mongolismus; in Lubarsch O, Henke E, Rossle R (eds): Handbuch der speziellen patholo- gischen Anatomie u. Histologie; vol 13: Nerven-system. Berlin, Springer, 1956, pp 82-98.
17. Kemper TL: Neuropathology of Down syndrome; in Nadel L (ed): The Psychobiology of Down Syndrome. Cambridge, MIT Press, 1988, pp 269-289.
18. Ross MH, Galaburda AM, Kemper TL: Down's syndrome: Is there a decreased population of neurons? Neurology (NY) 1984;34:909-916.
19. Scott BS, Petit TL, Becker LE, Edwards BAV: Abnormal electric membrane properties of Down's syndrome DRG neurons in cell culture. Dev Brain Res 1982;2:257-270.
20. Scott BS, Becker LE, Petit TL: Neurobiology of Down's syndrome. Prog Neurobiol 1983;21:199-237.
21. Becker LE, Armstrong DL, Chan F: Dendritic atrophy in children with Down's syndrome. Ann Neurol 1986;20:520-526.
22. Becker L, Mito T, Takashima S, Onodera K: Growth and development of the brain in Down syndrome. Prog Clin Biol Res 1991;373:133-152.
23. Wisniewski KE, Laure-Kamionowska M, Wisniewski HM: Evidence of arrest of neurogenesis and synaptogenesis in brains of patients with Down's syndrome (letter). N Engl J Med 1984;311:1187-1188.
24. Wisniewski KE, Laure-Kamionowska M, Connell F, Wen GY: Neuronal density and synaptogenesis in the postnatal stage of brain maturation in Down syndrome; in Epstein CJ (ed): The Neurobiology of Down Syndrome. New York, Raven Press, 1986, pp 29-44.
25. Wisniewski KE, Schmidt-Sidor B: Postnatal delay of myelin formation in brains from Down syndrome infants and children. Clin Neuropathol 1989;8:55-62.
26. Wisniewski KE, Beaulieu I, Bobinski M, Lee MH, Castells S: Microcephaly and neurological and neuropathological abnormalities in children with Down's syndrome; in Castells S, Wisniewski KE (eds): Growth Hormone Treatment in Down's Syndrome. Chichester, Wiley, 1993, pp 37-54.
27. Wisniewski KE: Down syndrome children often have brain with maturation delay, retardation of growth and cortical dysgenesis. Am J Med Genet Suppl 1990;7:274-281.
28. Sylvester PE: The hippocampus in Down's syndrome. J Ment Defic Res 1983;27:227-236.
29. Brooksbank BWL, Walker D, Balázs R, Jørgensen OS: Neuronal maturation in the foetal brain in Down's syndrome. Early Hum Dev 1989;18:237-246.
30. Benda CE: Mongolism; in Minckler J (ed): Pathology of the Nervous System, vol 2. New York, McGraw-Hill, 1971, pp 1361-1371.
31. Takashima S, Becker LE, Armstrong DL, Chan F: Abnormal neuronal development in the visual cortex of the human fetus and infant with Down's syndrome: A quantitative and qualitative Golgi study. Brain Res 1981;225:1-21.
32. Petit TL, LeBoutillier JC, Alfano DP, Becker LE: Synaptic development in the human fetus: A morphometric analysis of normal and Down's syndrome neocortex. Exp Neurol 1984;83:13-23.
33. Roche AF: The cranium in mongolism: A critical review. Acta Neurol Scand 1966;42:62-78.
34. Friede RL: Developmental Neuropathology, ed 2 revised and expanded. Berlin, Springer, 1989.
35. Zellweger H: Down syndrome; in Vinken P, Bruyn GW (eds): Congenital Malformations of the Brain and Skull, part II. Handbook Clin Neurol. Amsterdam, North Holland, 1977, vol 31, pp 367-469.
36. Gullotta F, Rehder H: Chromosomal anomalies and central nervous system. Beitr Pathol 1974;152:74-80.
37. Marin-Padilla M: Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi study. J Comp Neurol 1976;167:63-81.
38. Suetsugu M, Mehraein P: Spine distribution along the apical dendrites of the pyramidal neurons in Down's syndrome: A quantitative Golgi study. Acta Neuropathol (Berl) 1980;50:207-210.
39. Torrado C, Castells S: Diagnosis of hypothalamic dysfunction in Down's syndrome producing growth hormone deficiency; in Castells S, Wisniewski KE (eds): Growth Hormone Treatment in Down's Syndrome. Chichester, Wiley, 1993, pp 55-71.
40. Castells S, Beaulieu I, Wisniewski KE: Long-term effects of recombinant human growth hormone (rhGH) on children with Down's syndrome with short stature; in Castells S, Wisniewski KE (eds): Growth Hormone Treatment in Down's Syndrome. Chichester, Wiley, 1993, pp 163-182.
41. Castells S, Wisniewski KE: Treatment of growth retardation with recombinant human growth hormone in children with Down syndrome. Dev Brain Dysfunct, in press.
42. Wisniewski KE, Bobinski M: Hypothalamic abnormalities in Down syndrome. Prog Clin Biol Res 1991;373:153-167.
43. Annerén G, Sara VR, Hall K, Tuvemo T: Growth and somatomedin responses to growth hormone in Down's syndrome. Arch Dis Child 1986;61:48-52.
44. Annerén G, Carlsson-Skwirut C, Gustafsson J, Tuvemo T, Sara VR: Growth retardation in children with Down's syndrome in relation to insulin-like growth factors and growth hormone therapy; in Castells S, Wisniewski KE (eds): Growth Hormone Treatment in Down's Syndrome. Chichester, Wiley, 1993, pp 183-198.
45. Shapiro MB, Creasey H, Schwartz M, White B, Moore A, Rapoport SI: Quantitative CT analysis of brain morphometry in adult Down's syndrome at different ages. Neurology 1987;37:1424-1427.
46. Bloch B, Brazeau P, Ling N, Bohlen P, Esch F, Wehrenberg WB, Benoit R, Bloom F, Guillemin R: Immunohistochemical detection of growth hormone-releasing factor in brain (letter). Nature 1983;301:607-608.
47. Ling N, Esch F, Böhlen P, Brazeau P, Wehrenberg WB, Guillemin R: Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: Growth hormone-releasing factor. Proc Natl Acad Sci USA 1984;81:4302-4306.
48. Daikoku S, Kawano H, Noguchi M, Nakanishi J, Tokuzen M, Chihara K, Nagatsu I: GRF neurons in the rat hypothalamus. Brain Res 1986;399:250-261.
49. Niimi M, Takahara J, Sato M, Kawanishi K: Sites of origin of growth hormone-releasing factor-containing neurons projecting to the stalk-median eminence of the rat. Peptides 1989;10:605-608.
50. Ciofi P, Tramu G, Bloch B: Comparative immunohistochemical study of the distribution of neuropeptide Y, growth hormone-releasing factor and the carboxyterminus of precursor protein GHRF in the human hypothalamic infundibular area. Neuroendocrinology 1990;51:429-436.
51. Sweeney JE, Höhmann CF, Oster-Granite ML, Coyle JT: Neurogenesis of the basal forebrain in euploid and trisomy 16 mice: An animal model for developmental disorders in Down syndrome. Neuroscience 1989;31:413-425.
52. Zamenhof S: Stimulation of the proliferation of neurons by the growth hormone. I. Experiments on tadpoles. Growth 1941;5:123-139.
53. Zamenhof S: Stimulation of cortical-cell proliferation by the growth hormone. III. Experiments on albino rats. Physiol Zool 1942;15:281-292.
54. Zamenhof S, Mosley J, Schuller E: Stimulation of the proliferation of cortical neurons by prenatal treatment with growth hormone. Science 1966;152:1396-1397.
55. Sara VR, Lazarus L: Prenatal action of growth hormone on brain and behaviour. Nature 1974;250:257-258.
56. Noguchi T, Sugisaki T, Takamatsu K, Tsukada Y: Factors contributing to the poor myelination in the brain of the Snell dwarf mouse. J Neurochem 1982;39:1693-1699.
57. Noguchi T, Sugisaki T, Tsukada Y: Stimulation of Snell dwarf mouse neuronal growth by GH and T4. Neurochem Pathol 1984;2:123-138.
58. Noguchi T, Sugisaki T: Abnormal neuronal growth in the little (lit) cerebrum. Exp Neurol 1985:89:274-278.
59. Noguchi T, Sugisaki T, Tsukada Y: Microcephalic cerebrum with hypomyelination in the growth hormone-deficient mouse (lit). Neurochem Res 1985;10:1097-1106.
60. Eicher EM, Beamer WG: Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6. J Hered 1976;67:87-91.
61. Morisawa K, Sugisaki T, Kanamatsu T, Aoki T, Noguchi T: Factors contributing to cerebral hypomyelination in the growth hormone-deficient little mouse. Neurochem Res 1989;14:173-177.
62. Noguchi T, Sugisaki T, Nishikawa N, Tsukada Y: Restoration of microcephalic cerebrum with hypomyelination in the growth hormone-deficient mouse (lit): Stimulatory effects of GH restricted to the first 20 days of postnatal life. Neurochem Res 1988;13:249-252.
63. Caviedes P, Ault B, and Rapoport SI: The role of altered sodium currents in action potential abnormalities of cultured dorsal root ganglion neurons from trisomy 21 (Down syndrome) human fetuses. Brain Res 1990;510:229-236.
64. Caviedes P, Koistinaho J, Ault B, Rapoport SI: Effects of nerve growth factor on electrical membrane properties of cultured dorsal root ganglia neurons from normal and trisomy 21 human fetuses. Brain Res 1991;556:285-291.
65. Nieminen K, Suarez-Isla BA, and Rapoport SI: Electrical properties of cultured dorsal root ganglion neurons from normal and trisomy 21 human fetal tissue. Brain Res 1988;474:246-254.
66. Mandys V, Turecek R, Gispen WH, Bar PR: Organotypic cultures of chick dorsal root ganglia in a semi-solid medium: A model for neurotoxicity testing. Toxicol In Vitro 1994;8:81-90.
67. Dimberg Y, Hedlund K-O, Ebendal T: Effects of nerve growth factor on sensory neurons in the chick embryo: A stereological study. Int J Dev Neurosci 1987;5:207-213.