Cyclosporin A inhibits the degradation of signal sequences after processing of presecretory proteins by signal peptidase

European Journal of Biochemistry

Volumn 239, Issue 2, 1996, Pages 509-518

  Klappa, Peter ^a   Dierks, Thomas ^b   Zimmermann, Richard ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Cyclosporin A; Endoplasmic reticulum; Protein degradation; Signal peptidase

Indexed keywords

CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; PUROMYCIN; SIGNAL PEPTIDASE; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CROSS LINKING; DOG; ENDOPLASMIC RETICULUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TRANSPORT; PROTEOLIPOSOME;

ANIMALIA; CANIS FAMILIARIS;

EID: 0030057070     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0509u.x     Document Type: Article

References (45)

1. Zimmermann, R. & Meyer, D. I. (1986) 1986: a year of new insights into how proteins cross membranes, Trends Biochem. Sci. 11, 512-515.
2. Meyer, D. I. (1988) Preprotein conformation: the years major theme in translocation studies, Trends Biochem. Sci. 17, 474-478.
3. Rapoport, T. A. (1990) Protein transport across the ER membrane, Trends Biochem. Sci. 15, 355-358.
4. Thrift, R. N., Andrews, D. W., Walter, P. & Johnson, A. E. (1991) A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation, J. Cell Biol. 112, 809-821.
5. High, S., Görlich, D., Wiedmann, M., Rapoport, T. A. & Dobberstein, B. (1991) The identification of proteins in the proximity of signal-anchor sequences during their targeting to and insertion into the membrane of the ER, J. Cell Biol. 113, 35-44.
6. Görlich, D., Hartmann, E., Prehn, S. & Rapoport, T. A. (1992) A protein of the endoplasmic reticulum involved early in polypeptide translocation, Nature 357, 47-52.
7. Görlich, D., Prehn, S., Hartmann, E., Kalies, K.-U. & Rapoport, T. A. (1992) A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation, Cell 71, 489-503.
8. High, S., Andersen, S. L., Görlich, D., Hartmann, E., Prehn, S., Rapoport, T. A. & Dobberstein, B. (1993) Sec61p is adjacent to nascent type I and type II signal-anchor proteins during their membrane insertion, J. Cell Biol. 121, 743-750.
9. Shaw, A. S., Rottier, P. J. M. & Rose, J. K. (1988) Evidence for the loop model of signal-sequence insertion into the endoplasmic reticulum, Proc. Natl Acad. Sci. USA 85, 7592-7596.
10. Schlenstedt, G., Gudmundsson, G. H., Boman, H. G. & Zimmermann, R. (1992) Structural requirements for transport of preprocecropinA and related precursor proteins into mammalian microsomes, J. Biol. Chem. 267, 24328-24332.
11. Walter, P., Ibrahimi, I. & Blobel, G. (1981) Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein, J. Cell Biol. 91, 545-550.
12. Connolly, T. & Gilmore, R. (1986) Formation of a functional ribosome-membrane junction during translocation requires the participation of a GTP-binding protein, J. Cell Biol. 103, 2253-2261.
13. Römisch, K., Webb, J., Herz, J., Prehn, S., Frank, R., Vingron, M. & Dobberstein, B. (1989) Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP-binding domains, Nature 340, 478-482.
14. Connolly, T. & Gilmore, R. (1989) The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide, Cell 57, 599-610.
15. Miller, J. D., Wilhelm, H., Gierasch, L., Gilmore, R. & Walter, P. (1993) GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation, Nature 366, 351-354.
16. Connolly, T., Collins, P. & Gilmore, R. (1989) Access of proteinase K to partially translocated nascent polypeptides in intact and detergent-solubilized membranes, J. Cell Biol. 108, 299-307.
17. Dalbey, R. E. & von Heijne, G. (1992) Signal peptidases in prokaryotes and eukaryotes - a new protease family, Trends Biochem. Sci. 18, 334-338.
18. Klappa, P., Mayinger, P., Pipkorn, R., Zimmermann, M. & Zimmermann, R. (1991) A microsomal protein is involved in ATP-dependent transport of presecretory proteins into mammalian microsomes, EMBO J. 10, 2795-2803.
19. Schlenstedt, G., Gudmundsson, G. H., Boman, H. G. & Zimmermann, R. (1990) A large presecretory protein translocates both cotranslationally, using signal recognition particle and ribosome, and posttranslationally, without these ribonucleoparticles, when synthesized in the presence of mammalian microsomes, J. Biol. Chem. 265, 13960-13968.
20. Klappa, P., Zimmermann, M. & Zimmermann, R. (1994) The membrane proteins TRAMp and sec61αp may be involved in posttranslational transport of presecretory proteins into mammalian microsomes, FEBS Lett. 341, 281-287.
21. Görlich, D. & Rapoport, T. A. (1993) Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane, Cell 75, 615-630.
22. Kobashi, K. (1968) Catalytic oxidation of sulfhydryl groups by o-phenanthroline copper complex, Biochim. Biophys. Acta 158, 239-245.
23. Klappa, P., Freedman, R. B. & Zimmermann, R. (1995) Protein disulphide isomerase and lumenal cyclophilin-type peptidyl cistrans isomerase are in transient contact with secretory proteins during late stages of translocation, Eur. J. Biochem. 232, 755-764.
24. Rowling, P. J. E. & Freedman, R. B. (1993) Folding, assembly, and posttranslational modifications of proteins within the lumen of the endoplasmic reticulum, Subcell. Biochem. 21, 41-80.
25. Klappa, P., Zimmermann, M., Dierks, T. & Zimmermann, R. (1993) Components and mechanisms involved in transport of proteins into the endoplasmic reticulum, Subcell. Biochem. 21, 17-40.
26. Lyko, F., Martoglio, B., Jungnickel, B., Rapoport, T. A. & Dobberstein, B. (1995) Signal sequence processing in rough microsomes, J. Biol. Chem. 270, 19873-19878.
27. Ciechanover, A. (1994) The ubiquitin-mediated proteolytic pathway: mechanisms of action and cellular physiology, Biol. Chem. Hoppe-Seyler 375, 565-581.
28. Peters, J.-M. (1994) Proteasomes: protein degradation machines of the cell, Trends Biochem. Sci. 19, 377-382.
29. Henderson, R. A., Michel, H., Sakaguchi, K., Shabanowitz, J., Appella, E., Hunt, D. F. & Engelhard, V. H. (1992) HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation, Science 255, 1264-1266.
30. Wei, M. L. & Cresswell, P. (1992) HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature 356, 443-446.
31. Urade, R., Nasu, M., Moriyama, T., Wada, K. & Kito, M. (1992) Protein degradation by the phosphoinositide-specific phospholipase C-α family from rat liver endoplasmic reticulum, J. Biol. Chem. 267, 15152-15159.
32. Urade, R., Takenaka, Y. & Kito, M. (1993) Protein degradation by ERp72 from rat and mouse liver endoplasmic reticulum, J. Biol. Chem. 268, 22004-22009.
33. Ichihara, S., Beppu, N. & Mizushima, S. (1984) Protease IV, a cytoplasmic membrane protein of Escherichia coli, has signal peptide peptidase activity, J. Biol. Chem. 259, 9853-9857.
34. Price, W. R., Zydowsky, L. D., Jin, M., Baker, C. H., McKeon, F. D. & Walsh, C. T. (1991) Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence, Proc. Natl Acad. Sci. USA 88, 1903-1907.
35. Kunz, J. & Hall, M. N. (1993) Cyclosporin A, FK506 and rapamycin: more than just immunosuppression, Trends Biochem. Sci. 18, 334-338.
36. Bose, S. & Freedman, R. B. (1994) Peptidyl prolyl cis-trans-isomerase activity associated with the lumen of the endoplasmic reticulum, Biochem. J. 300, 865-870.
37. Bose, S., Mücke, M. & Freedman, R. B. (1994) The characterization of a cyclophilin-type peptidyl prolyl cis-trans-isomerase from the endoplasmic reticulum, Biochem. J. 300, 871-875.
38. Hwang, C., Sinskey, A. J. & Lodish, H. F. (1992) Oxidized redox state of glutathione in the endoplasmic reticulum. Science 257, 1496-1502.
39. Fra, A. M., Fagioli, C., Finazzi, D., Sitia, R. & Alberini, C. M. (1993) Quality control of ER synthesized proteins: an exposed thiol group as a three-way switch mediating assembly, retention and degradation, EMBO J. 12, 4755-4761.
40. Fra, A. M. & Sitia, R. (1993) The endoplasmic reticulum as a site of protein degradation, Subcell. Biochem. 21, 143-168.
41. Evans, E. A., Gilmore, R. & Blobel, G. (1986) Purification of microsomal signal peptidase as a complex, Proc. Natl Acad. Sci. USA 83, 581-585.
42. Shelness, G. S., Kanwar, Y. S. & Blobel, G. (1988) cDNA-derived primary structure of the glycoprotein component of canine microsomal signal peptidase complex, J. Biol. Chem. 263, 17063-17070.
43. Greenburg, G., Shelness, G. S. & Blobel, G. (1989) A subunit of mammalian signal peptidase is homologous to yeast Sec11 protein, J. Biol. Chem. 264, 15762-15765.
44. Shelness, G. S. & Blobel, G. (1990) Two subunits of the canine signal peptidase complex are homologous to yeast Sec11 protein, J. Biol. Chem. 265, 9512-9519.
45. Hartmann, E., Sommer, T., Prehn, S., Görlich, D., Jentsch, S. & Rapoport, T. A. (1994) Evolutionary conservation of components of the protein translocation complex, Nature 367, 654-657.