Dose-related gastrointestinal response to the ingestion of either isomalt, lactitol or maltitol in milk chocolate

European Journal of Clinical Nutrition

Volumn 50, Issue 1, 1996, Pages 17-21

  Koutsou, G A ^a   Storey, D M ^a   Lee, A ^a   Zumbe, A ^a   Flourie, B ^b   Lebot, Y ^c   Olivier, Ph ^c  

^a UNIVERSITY OF SALFORD   (United Kingdom)

^b Hopital Saint Lazare   (France)

^c Roquette Freres   (France)

Author keywords

Humans; Isomalt; Lactitol; Maltitol; Polyols; Sugar alcohols; Tolerance

Indexed keywords

ISOMALT; LACTITOL; MALTITOL; POLYOL; SUGAR ALCOHOL;

ADULT; ARTICLE; BORBORYGMUS; CACAO; CLINICAL TRIAL; COLIC; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; FLATULENCE; FOOD INTAKE; GASTROINTESTINAL SYMPTOM; GASTROINTESTINAL TRACT FUNCTION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SYMPTOMATOLOGY;

ADOLESCENT; ADULT; ANIMALS; CACAO; CROSS-OVER STUDIES; DIARRHEA; DISACCHARIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FLATULENCE; GASTROINTESTINAL MOTILITY; HUMANS; MALE; MALTOSE; MILK; SEVERITY OF ILLNESS INDEX; SUGAR ALCOHOLS; SWEETENING AGENTS;

EID: 0030057021     PISSN: 09543007     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Abraham RR, Davies M, Yudkin J & Williams R (1981): Controlled clinical trial of a new non-calorigenic sweetening agent. J. Hum. Nutr. 35, 165-172.
2. Beaugerie L, Flourie B, Marteau P, Pellier P, Franchisseur C & Rambaud JC (1990): Digestion and absorption in the human intestine of three sugar alcohols. Gastroenterology 99, 717-723.
3. Beaugerie L, Flourie B, Pellier P, Achour L, Franchisseur C & Rambaud JC (1991): Tolerance clinique, absorption intestinale et valeur energetique de quatre polyols pris a jeun. Gastroenterol. Clin. Biol. 15, 929-932.
4. Billaux MS, Flourie B, Jacquemin C & Messing B (1991): Sugar Alcohols. In Handbook of sweeteners, eds S Marie & JR Liggot, pp 72-103. Glasgow and London: Blackie.
5. 2) measurements to quantitate carbohydrate absorption. J. Clin. Invest. 51, 1219-1225.
6. COMA (1994): Department of Health Report on Health and Social Subjects. Report of the Cardiovascular Review Group-Committee on Medical Aspects of Food Policy. 46th Nutritional Aspects of Cardiovascular Disease. London: Her Majesty's Stationary Office. ISBN 011 321 8753.
7. Dahlqvist A & Telenius U (1965): The utilisation of a presumably low-calorigenic carbohydrate derivative. Acta Physiol. Scand. 63, 156-163.
8. Gart JJ (1969): An exact test for comparing matched proportions in cross-over designs. Biometrica 56, 75-80.
9. Goovaerts L & Ravelli GP (1993): Lactitol monohydrate for the treatment of chronic constipation: A multicentre study of the efficacy and tolerability of an individually adjusted daily dose. Acta Therapeut. 19, 61-71.
10. Grenby TH & Phillips A (1989): Dental and metabolic effects of lactitol in the diet of laboratory rats. Br. J. Nutr. 61, 17-24.
11. Grimble GK, Patil DH & Silk DBA (1988): Assimilation of lactitol, an 'unabsorbed' disaccharide in the normal human colon. Gut. 29, 1666-1671.
12. Grupp U & Siebert G (1978): Metabolism of hydrogenated palatinose, an equimolar mixture of alpha-D-glucopyranosido-1, 6-sorbitol and alpha-D-glucopyranosido-1,6-mannitol. Res. Exp. Med. (Berlin). 173, 261-278.
13. Hammer HF, Santa Ana CA, Schiller LR & Fordtran JS (1989): Studies of osmotic diarrhoea induced in normal subjects by ingestion of polyethylene glycol and lactulose. J. Clin. Invest. 84, 1056-1062.
14. Langkilde AM, Anderson H, Schweiser TF & Wursch P (1994): Digestion and absorption of sorbitol, maltitol and isomalt from the small bowel: A study in ileostomy subjects. Eur. J. Clin. Nutr. 48, 768-775.
15. Lee A, Zumbe A & Storey DM (1994): Breath hydrogen after ingestion of the bulk sweeteners sorbitol, isomalt and sucrose in chocolate. Br. J. Nutr. 71, 731-737.
16. Lian-Loh R, Birch GG & Coates ME (1982): The metabolism of maltitol in the rat. Br. J. Nutr. 48, 477-481.
17. Livesey G (1992): The energy values of dietary fibre and sugar alcohols for man Nutr. Res. Rev. 5, 61-84.
18. 2) technique: the stoichiometry of hydrogen production and the interaction between carbohydrates assessed in vivo and in vitro. Eur. J. Clin Nutr. 47, 419-430.
19. Macfarlane GT & Cummings JH (1991): The colonic flora, fermentation and large bowel digestive function. In The large intestine: physiology, pathophysiology and disease, eds SF Phillips, JH Pemberton & RG Shorter, pp 51-92. New York: Raven Press.
20. McNemar Q (1947): Note on the sampling error of the difference between correlated proportions or percentages. Psychometrika 12, 153-157.
21. Metzger J, Chollet C, Wermeille M, Biollaz J, Llull JB & Lauterburg BH (1988): Lactitol: Gastrointestinal absorption and effect on blood lactate in healthy volunteers and patients with cirrhosis. Eur. J. Clin. Pharmacol. 35, 97-99.
22. Nilsson U & Jagerstad M (1987): Hydrolysis of lactitol maltitol and palatinit® by human internal biopsies. Br. J. Nutr. 58, 199-206.
23. Rambaud JC & Flourie B (1994): Mechanism of carbohydrate-induced diarrhoea. In Short chain fatty acids, eds HJ Binder, JH Cummings & K Soergel, pp 232-239. Kluwer Academic Publishers.
24. Rosiers C, Verwaerde F, Dupas H & Bouquelet S (1985): New approach to the metabolism of hydrogenated starch hydrolysate: hydrolysis by maltase/glucoamylase complex of the rat intestinal mucosa. Ann. Nutr. Metab. 29, 76-82.
25. Saunders DR & Wiggins HS (1981): Conservation of mannitol, lactulose and raffinose by the human colon. Am. J. Physiol. 241, G397-G402.
26. Sicard PJ & Le Bot Y (1994): Manufacturing opportunities with non-sugar sweeteners. In Sugarless - towards the year 2000, ed AJ RuggGunn, pp 112-135. Cambridge: The Royal Society of Chemistry.
27. Storey DM, Koutsou GA, Lee A, Zumbe A, Le Bot Y, Olivier Ph & Flourie B submitted for publication: Tolerability, acceptance and breath hydrogen excretion following ingestion of maltitol in chocolate consumed with and without fasting. Eur. J. Clin. Nutr.
28. Wursch P & Del Vedovo S (1981): Inhibition of human digestive enzymes by hydrogenated malto-oligosaccharides. Int. J. Vitam. Nutr. Res. 51, 161-165.
29. Wursch P, Koellreuter B & Schweizer TF (1989): Hydrogen excretion after ingestion of five different sugar alcohols and lactulose. Eur. J. Clin. Nutr. 43, 819-825.
30. Wursch P, Koelreuter B, Getaz F & Arnaud MJ (1990): Metabolism of maltitol by conventional rats and mice, and germ-free mice, and comparability between malyiyol and sorbitol in germ-free mice. Br. J. Nutr. 63, 7-15.
31. Ziesenitz SC & Siebert G (1987): The metabolism and utilisation of polyols and other bulk sweeteners compared with sugar. In Development in sweeteners, vol 3, ed TH Grenby, pp 109-149. Barking, UK: Elsevier.
32. Zumbe A, Lee A, & Storey DM (1994): Manufacture and marketing of non-sugar chocolate In Sugarless - towards the year 2000, ed AJ Rugg-Gunn, pp 147-171. Cambridge: Royal Society of Chemistry.
33. Zunft H-J., Schulze J, Gartner H & Grutte F-K (1983): Digestion of maltitol in man rat and rabbit. Ann. Nutr. Metab. 27, 470-476.