Evaluation in rats of the dose-response relationship among colonic mucosal growth, colonic fermentation, and dietary fiber

Digestive Diseases and Sciences

Volumn 41, Issue 7, 1996, Pages 1458-1467

  Whiteley, Laurence O ^a   Higgins, Janet M ^a   Purdon, Mike P ^a   Ridder, Gregg M ^a   Bertram, Timothy A ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

colon; dietary fiber; fermentation; growth; stereology

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; COLON MUCOSA; CONTROLLED STUDY; DIETARY FIBER; DOSE RESPONSE; FERMENTATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOLOGY; TISSUE GROWTH;

ANIMALS; BODY WEIGHT; BUTYRIC ACID; BUTYRIC ACIDS; CELLULOSE; COLON; DIETARY FIBER; EATING; FATTY ACIDS, VOLATILE; FECES; FERMENTATION; GALACTANS; GASTROINTESTINAL CONTENTS; INTESTINAL MUCOSA; MALE; MANNANS; ORGAN SIZE; PLANT GUMS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030056514     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02088573     Document Type: Article

References (49)

1. Johnson LR: Regulation of gastrointestinal growth. In Physiology of the Gastrointestinal Tract. LR Johnson (ed). New York, Raven Press, 1987, pp 301-334
2. Tutton PJM, Barkla DH: Neural control of colonic cell proliferation. Cancer 45:1172-1177, 1980
3. McCormack SA, Johnson LR: Role of polyamines in gastrointestinal mucosal growth. Am J Physiol 260:G795-G806, 1991
4. Kripke SA, Fox AD, Berman JM, Settle RG, Rombeau JL: Stimulation of intestinal mucosal growth with intracolonic infusion of short-chain fatty acids. J Parent Enter Nutr 13:109-116, 1989
5. Sakata T: Stimulatory effect of short-chain fatty acids on epithelial cell proliferation of isolated and denervated jejunal segment of the rat. Scand J Gastroenterol 24:886-890, 1989
6. Kissmeyer-Nielsen P, Mortensen FV, Laurberg S: Transmural trophic effect of short chain fatty acid infusion on atrophic, defunctioned rat colon. Dis Colon Rectum 38:946-951, 1995
7. Williamson RC, Rainey JB: The relationship between intestinal hyperplasia and carcinogenesis. Scand J Gastroenterol Suppl 104:57-76, 1984
8. Albanes D, Salbe AD, Levander OA, Taylor PR, Nixon DW, Winick M: The effect of early caloric restriction on colonic cellular growth in rats. Nutr Cancer 13:73-80, 1990
9. Albanes D, Winick M: Are cell number and cell proliferation risk factors for cancer. J Natl Cancer Inst 80:772-775, 1988
10. Giovannucci E, Ascherio A, Rimm EB, Colditz GA, Stampfer MJ, Willett WC: Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med 122:327-334, 1995
11. Lupton JR, Kurtz PP: Relationship of colonic luminal short-chain fatty acids and pH to in vivo cell proliferation in rats. J Nutr 123:1522-1530, 1993
12. Jacobs LR, Lupton JR: Relationship between colonic luminal pH, cell proliferation, and colon carcinogenesis in 1,2-dimethylhydrazine treated rats fed high fiber diets. Cancer Res 46:1727-1734, 1986
13. Boffa LC, Lupton JR, Mariani MR, Ceppi M, Newmark HL, Scalmati A, Lipkin M: Modulation of colonic epithelial cell proliferation, histone acetylation, and luminal short chain fatty acids by variation of dietary fiber (wheat bran) in rats. Cancer Res 52:5906-5912, 1992
14. Butler RN, Bruhn B, Pascoe V, Fettman MJ, Roberts TIC: Regional factors affecting proliferation in the large intestine of the rat. Proc Soc Exp Biol Med 200:133-137, 1992
15. Fleming SE, Fitch MD, De Vries S: The influence of dietary fiber on proliferation of intestinal mucosal cells in miniature swine may not be mediated primarily by fermentation. J Nutr 122:906-916, 1992
16. Wyatt GM, Horn N, Gee JM, Johnson IT: Intestinal microflora and gastrointestinal adaptation in the rat in response to non-digestible dietary polysaccharides. Br J Nutr 60:197-207, 1988
17. Whiteley LO, Purdon MP, Ridder GM, Bertram TA: The interaction of diet and colonic microflora in regulating colonic mucosal growth. Toxicol Pathol 24:1996 (in press)
18. Bertram TA: Gastrointestinal tract. In Handbook of Toxicologic Pathology. WM Haschek, CG Rousseaux (eds). San Diego, Academic Press, 1991, pp 195-250
19. Bieri JG, Stoewsand GS, Briggs GM, Phillips RW, Woodard JC, Knapka JJ: Report of the American institute of nutrition ad hoc committee on standards for nutritional studies. J Nutr 110:1726, 1980
20. Harris PJ, Ferguson LR: Dietary fiber: Its composition and role in protection against colorectal cancer. Mutat Res 290:97-110, 1993
21. Jacobs LR, Lupton JR: Effect of dietary fibers on rat large bowel mucosal growth and cell proliferation. Am J Physiol 246:G378-G385, 1984
22. Reddy BS, Spiller GA: Modification by dietary fiber of toxic or carcinogenic effects. In CRC Handbook of Dietary Fiber in Human Nutrition. GA Spiller (ed). Boca Raton, CRC Press, 1993, pp 501-506
23. Heitman DW, Hardman WE, Cameron IL: Dietary supplementation with pectin and guar gum on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. Carcinogenesis 13:815-818, 1992
24. Scherle W: A simple method for volumetry of organs in quantitative stereology. Mikroskopie 26:57-60, 1970
25. Weibel ER, Elias H: Quantitative Methods in Morphology. New York, Springer-Verlag, 1967
26. Zijlstra JB, Beukema J, Wolthers BG, Byrne BM, Groen A, Dankert J: Pretreatment methods prior to gas chromatographic analysis of volatile fatty acids from fecal samples. Clin Chim Acta 78:243-250, 1977
27. Snedecor GW, Cochran WG. Statistical Methods, 8th ed. Ames, Iowa, University Press. 1989
28. Billingham RE, Medawar PB: Contracture and intussusceptive growth in the healing of extensive wounds in mammalian skin. J Anat 89:114-123, 1955
29. Burnham DB: Epithelial cell production and mucosal morphology in colonic obstruction. Cell Tissue Res 230:185-196, 1983
30. Leroy F, Van Hoeck J, Bogaert C: Effect of uterine distention and of oestradiol on cell kinetics in the endometrial epithelium of ovarectomized rats. Cell Tissue Kinet 10:437-145, 1977
31. Putz PH, Willems G: Cell proliferation in the human gallbladder epithelium: Effect of distention. Gut 20:246-248, 1979
32. Stragand JJ, Hagemann RF: Effect of luminal contents on colonic cell replacement. Am J Physiol 233:E208-E211, 1977
33. Goodlad RA, Lenton W, Ghatei TE, Bloom SR, Wright NA: Effect of an elemental diet, inert bulk and different types of dietary fibre on the response of the intestinal epithelium to refeeding in the rat and relationship to plasma gastrin, enteroglucagon and PYY concentration. Gut 28:171-180, 1987
34. Levine GM: Regulation of intestinal mucosal growth. In Growth of the Gastrointestinal Tract: Gastrointestinal Hormones and Growth Factors. J Morisset, TE Solomon (eds). Boca Raton, CRC Press, 1991, pp 176-189
35. Schrezenmeir J, Kasper H: The influence of dietary-fiber substances on the release of gastrointestinal hormones. In Fak Symposium 32: Colon and Nutrition. H Kasper, H Goebell (eds). Lancaster, MTP Press, 1982, pp 71-76
36. Seidel ER, Snyder RG: Pentagastrin induction of spermine/spermidine N1-acetyltransferase and mucosal polyamines. Am J Physiol 256:G16-G21, 1989
37. Sircar B, Johnson LR, Lichtenberger LM: Effect of synthetic diets on gastrointestinal mucosal DNA synthesis in rats. Am J Physiol 244:G327-G335, 1983
38. Sircar B, Johnson LR, Lichtenberger LM: Effect of chemically defined diets on antral and serum gastrin levels in rats. Am J Physiol 238:G376-G383, 1980
39. Seidel ER, Haddox MK, Johnson LR: Polyamines in the response to intestinal obstruction. Am J Physiol 246:G649-G653, 1984
40. Deschner EE, Cohen BI, Raicht RF: Acute and chronic effect of dietary cholic acid on colonic epithelial cell proliferation. Digestion 21:290-296, 1981
41. Zhang J, Lupton JR: Dietary fibers stimulate colonic cell proliferation by different mechanisms at different sites. Nutr Cancer 22:267-276, 1994
42. Sakata T: Short chain fatty-acids as the luminal trophic factor. Can J Anim Sci Suppl 64:189-190, 1984
43. Frankel WL, Zhang W, Singh A, Klurfeld DM, Don S, Sakata T, Modlin I, Rombeau JL: Mediation of the trophic effects of short-chain fatty acids on the rat jejunum and colon. Gastroenterology 106:375-380, 1994
44. Friedel D, Levine GM: Effect of short-chain fatty acids on colonic function and structure. J Parenter Enteral Nutr 16:1-4, 1992
45. Sakata T: Effects of indigestible dietary bulk and short chain fatty acids on the tissue weight and epithelial cell proliferation rate of the digestive tract in rats. J Nutr Sci Vitaminol (Tokyo) 32:355-362, 1986
46. Wilcox DK, Higgins J, Bertram TA: Colonic epithelial cell proliferation in a rat model of nongenotoxin-induced colonic neoplasia. Lab Invest 67:405-411, 1992
47. Mallett AK, Wise A, Rowland IR: Hydrocolloid food additives and rat caecal microbial enzyme activities. Food Chem Toxicol 22:415-418, 1984
48. Maskens AP: Histogenesis of colon glands during postnatal growth. Acta Anat 100:17-26, 1978
49. Lee DYK, Chapkin RS, Lupton JR: Dietary fat and fiber modulate colonic cell proliferation in an interactive site-specific manner. Nutr Cancer 20:107-118, 1993