Synthesis and calcium antagonistic activity of 8-[N-[2-(3,4-dimethoxyphenyl)ethyl]-β-alanyl]-5,6,7,8-tetrahydrothien o[3,2-b][1,4]thiazepine fumarate

Archiv der Pharmazie

Volumn 329, Issue 7, 1996, Pages 347-351

  Erker, Thomas ^a   Laimer, Ingrid ^a   Huck, Sigismund ^a   Boehm, Stefan ^a   Studenik, Christian ^b   Heistracher, Peter ^b  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

calcium antagonist; KT 362; thieno analog; thieno 3,2 b 1,4 thiazepine

Indexed keywords

5 [N (3,4 DIMETHOXYPHENETHYL) BETA ALANYL] 2,3,4,5 TETRAHYDRO 1,5 BENZOTHIAZEPINE HYDROGEN FUMARATE; CALCIUM ANTAGONIST; DILTIAZEM; FUMARIC ACID DERIVATIVE; THIAZEPINE DERIVATIVE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; GUINEA PIG; HEART ARRHYTHMIA; HEART MUSCLE CONTRACTILITY; HEART PAPILLARY MUSCLE; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; SPINAL GANGLION;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CATTLE; CHICK EMBRYO; GANGLIA, SPINAL; GUINEA PIGS; ION CHANNEL GATING; MYOCARDIAL CONTRACTION; SODIUM CHANNELS; THIAZEPINES;

EID: 0030056425     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.19963290704     Document Type: Article

References (29)

1. Studies on the Chemistry of Thienoanellated O,N- and S,N-containing Heterocycles - Part 13; for Part 12 see: T. Erker, Sci. Pharm. 1994, 62, 337-346.
2. T.E. Mecca, S.D. Love, J. Cardiovasc. Pharmacol. 1992, 20, 678-682.
3. S. Murata, K. Kikkawa, T. Nagao, J. Cardiovasc. Pharmacol. 1992, 19, 790-797.
4. S.W. Rabkin, Neuropharmacol., 1992, 31, 487-496.
5. M. Schramm, R. Towart, Life Sciences 1985, 37, 1843-1860.
6. I. Kodama, S. Shibata, J. Pharmacol Exp. Ther. 1991, 258 (1), 332-338.
7. N. Buljubasic, J. Marijic, D.F. Stowe, G.J. Gross, J.P. Kampine, Z.J. Bosnjak, J. Cardiovasc. Pharmacol. 1991, 18 (4), 594-604.
8. K. Sakata, H. Karaki, Brit. J. Pharmacol 1991, 102, 174-178.
9. R.K. Hester, S. Shibata, Cardiovasc. Drug Ther. 1990, 4(5), 1345-1354.
10. I. Laimer, T. Erker, Sci. Pharm. 1994, 39 - 49.
11. S. Gronowitz, R.K. Morris R.K., Aminothiophenes and Their Derivatives. In Thiophene and Its Derivatives, Part II, Interscience Publication, John Wiley and Sons: Inc. New York, 1986; pp 631-799.
12. A.M. Greenspan, M. Morad, Circulation 62, 1980, Suppl.III, 3-283.
13. H. Nakajima, M. Hoshiyama, K. Yamashita, A. Kiyomoto, Jpn. J. Pharmacol. 1975, 25, 383-392.
14. J. Herrington, C.J. Lingle, J. Neurophysiol. 1992, 68, 213-232.
15. N. Hagiwara, H. Irisawa, M. Kameyama, J. Physiol. 1988, 395, 233-253.
16. J.P. Galper, W.A. Catterall, Mol. Pharmacol. 1979, 15, 174-178.
17. L.W. Haynes, J. Gen. Physiol. 1992, 100, 783-801.
18. S. Gurtu, S. Seth, A.K. Roychoudhary, Naunyn-Schmiedeberg's Arch. Pharmacol. 1992, 345, 172-175.
19. S. Boehm, S. Huck, Europ. J. Neurosci. 1993, 5, 1280-1286.
20. E.W. McCleskey, A.P. Fox, D.H. Feldman, L.J. Cruz, B.M. Olivera, Proc. Natl. Acad. Sci. 1987, 84, 4327-4331.
21. C.R. Artalejo, M.E. Adams, A.P. Fox, Nature 1994, 367, 72-76.
22. M. Reiter, Arzneim. Forsch. 1967, 17, 1247-1253.
23. B.P. Bean, Ann. Rev. Physiol. 1989, 51, 367-384.
24. M. Spedding, R. Paoletti, Pharmacol. Reviews 1992, 44, 363-376.
25. A. DeLean, P.J. Munson, D. Rodbard, Am. J. Physiol. 1978, 235, E97-E102.
26. G. Cargnelli, R. Padrini, D. Piovan, R. Moretto, S. Bova, Eur. J. Pharm. 1987, 136, 163-170.
27. J.E. Perez, L. Borda, R. Schuchleib, P.D. Henry, J. Pharm. Exp. Ther. 1982, 227, 609-613.
28. H. Nakajima, M. Hoshijama, K. Yamashita, A. Kiyomoto, Japan. J. Pharmacol. 1975, 25, 383-392
29. C. Hirth, U. Borchard, D. Hafner, J Mol. Cell. Cardiol. 1983, 15, 799-809.