The pharmacokinetics of continuous epidural sufentanil and bupivacaine infusion after thoracotomy

Anesthesia and Analgesia

Volumn 83, Issue 2, 1996, Pages 401-406

  Hansdóttir, Vigdís ^a   Woestenborghs, Robert ^b   Nordberg, Gunnar ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; SUFENTANIL;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; EPIDURAL DRUG ADMINISTRATION; HUMAN; LUNG TUMOR; PAIN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL; STEADY STATE; THORACOTOMY;

ANALGESIA, EPIDURAL; ANALGESICS, OPIOID; ANESTHESIA, EPIDURAL; ANESTHETICS, LOCAL; BUPIVACAINE; DOUBLE-BLIND METHOD; HALF-LIFE; HUMANS; METABOLIC CLEARANCE RATE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; SUFENTANIL; THORACOTOMY;

EID: 0030056229     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199608000-00034     Document Type: Article

References (19)

1. Glynn C, Mather L, Cousins M, et al. Spinal narcotics and respiratory depression. Lancet 1979;2:356-7.
2. Chrubasik J, Chrubasik S, Martin E. The ideal epidural opioid - fact or fantasy. Eur J Anaesthesiol 1993;10:79-100.
3. Salomäki T, Laitinen J, Nuutinen L. A randomized double-blind comparison of epidural versus intravenous fentanyl infusion for analgesia after thoracotomy. Anesthesiology 1991;75:790-5.
4. Nordberg G, Borg L, Hedner T, et al. CSF and plasma pharmacokinetics of intramuscular morphine. Eur J Clin Pharmacol 1985;27:677-81.
5. Nordberg G, Hansdottir V, Kvist L, et al. Pharmacokinetics of different epidural sites of morphine administration. Eur J Pharmacol 1987;33:499-504.
6. Hansdóttir V, Woestenborghs R, Nordberg G. The cerebrospinal fluid and plasma pharmacokinetics of sufentanil after thoracic or lumbar epidural administration. Anesth Analg 1995;80: 724-9.
7. Taverne RH, Ionescu TI, Nuyten ST. Comparative absorption and distribution pharmacokinetics of intravenous and epidural sufentanil for major abdominal surgery. Clin Pharmacokinet 1992;23:231-7.
8. Mourisse J, Hasenbos MA, Gielen MJ, et al. Epidural bupivacaine, sufentanil or the combination for post-thoracotomy pain. Acta Anaesthesiol Scand 1992;36:70-4.
9. Kavanagh B, Katz J, Sandler A. Pain control after thoracic surgery. Anesthesiology 1994;81:737-59.
10. Auwera DVd, Verborgh C, Camu F. Analgesic and cardiorespiratory effects of sufentanil and morphine in humans. Anesth Analg 1987;66:999-1003.
11. Hansdóttir V, Bake B, Nordberg G. The analgesic efficacy and adverse effects of continuous epidural sufentanil and bupivacaine infusion after thoracoctomy. Anesth Analg 1996;83: 394-400.
12. Woestenborghs R, Timmerman P, Cornelissen M-L, et al. Assay methods for sufentanil in plasma: radioimmunoassay versus gas chromatography-mass spectrometry. Anesthesiology 1994; 80:666-70.
13. Hansdóttir V, Hedner T, Woestenborghs R, et al. The CSF and plasma pharmacokinetics of sufentanil after intrathecal administration. Anesthesiology 1991;74:264-9.
14. Shafer S, Varvel J. Pharmacokinetics, pharmacodynamics, and rational opioid selection. Anesthesiology 1991;74:53-63.
15. Lehmann K, Gerhard A, Horrichs-Haermeyer G, et al. Postoperative patient-controlled analgesia with sufentanil: analgesic efficacy and minimum effective concentrations. Acta Anaesthesiol Scand 1991;35:221-6,
16. Deleted in proof.
17. Harbers JB, Hasenbos MA, Gort C, et al. Ventilatory function and continuous high thoracic epidural administration of bupivacaine with sufentanil intravenously or epidurally: a double- blind comparison. Reg Anesth 1991;16:65-71.
18. Hudson R, Bergström R, Thomson I, et al. Pharmacokinetics of sufentanil in patients undergoing abdominal aortic surgery. Anesthesiology 1989;70:426-31.
19. Meuldermans W, Hurkmans R, Heykants J. Plasma protein binding and distribution of fentanyl, sufentanil, alfentanil and lofentanil in blood. Arch Int Pharmacodyn Ther 1982;257:4-19.