Decreased vasoactive intestinal peptide levels and glutathione depletion in acquired megacolon

Digestive Diseases and Sciences

Volumn 41, Issue 7, 1996, Pages 1409-1416

  Koch, Timothy R ^a   Schulte Bockholt, Arnd ^b   Otterson, Mary F ^b   Telford, Gordon L ^b   Stryker, Steven J ^b   Ballard, T ^b   Opara, Emmanuel C ^b  

^a CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

colon; glutathione; megacolon; NADPH diaphorase; vasoactive intestinal peptide

Indexed keywords

GLUTATHIONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MEGACOLON; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; COLON; GLUTATHIONE; HUMANS; INTESTINAL MUCOSA; MEGACOLON; MIDDLE AGED; MUSCLE, SMOOTH; NADPH DEHYDROGENASE; RADIOIMMUNOASSAY; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0030056153     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02088566     Document Type: Article

References (51)

1. Boeckxstaens GE, Pelckmans PA, Herman AG, Van Maercke YM: Involvement of nitric oxide in the inhibitory innervation of the human isolated colon. Gastroenterology 104:690-697, 1993
2. Bredt DS, Glatt CE, Hwang PM, Fotuhi M, Dawson TM, Snyder SH: Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron 7:615-624, 1991
3. Keef KD, Du C, Ward SM, McGregor B, Sanders KM: Enteric inhibitory neural regulation of human colonic circular muscle: role of nitric oxide. Gastroenterology 105:1009-1016, 1993
4. Furness JB, Pombolo S, Young HM, Li ZS, McConalogue K, Kunze WAA, Bornstein JC: Structure and function of chemically specified enteric neurons in the guinea pig intestine. Regul Pept 40(2):151, 1992
5. Grider JR: Interplay of VIP and nitric oxide in regulation of the descending relaxation phase of peristalsis. Am J Physiol 264:G334-G340, 1993
6. 2+ influx activates a constitutive NOS in dispersed gastric muscle cells. Am J Physiol 265(Gastrointest Liver Physiol 28):G660-G671, 1993
7. Dawson TM, Bredt DS, Fotuhi M, Hwang PM, Snyder SH: Nitric oxide synthase and neuronal NADPH-d are identical in brain and peripheral tissue. Proc Natl Acad Sci USA 88:7797-7801, 1991
8. Aimi Y, Kimura H, Kinoshita T, Minami Y, Fujimura M, Vincent SR: Histochemical localization of nitric oxide synthase in rat enteric nervous system. Neuroscience 53:553-560, 1993
9. Gaumnitz E, Sweet MA, Sengupta A, Singaram C: Nitrinergic and peptidergic innervations and their inter-relationships in human colon. Neuropeptides 29:1-9, 1995
10. Saffrey MJ, Hassall CJS, Hoyle CHF, Belai A, Moss J, Schmidt HH, Förstermann U, Murad F, Burnstock G: Colocalization of nitric oxide synthase and NADPH-diaphorase in cultured myenteric neurones. Neuroreport 3:333-336, 1992
11. Young HM, Furness JB, Shuttleworth CWR, Bredt DS, Snyder SH: Co-localization of nitric oxide synthase immunoreactivity and NADPH diaphorase staining in neurons of the guinea-pig intestine. Histochemistry 97:375-378, 1992
12. Ny L, Aim P, Ekstrom P, Hannibal J, Larsson B, Andersson K-E: Nitric oxide synthase-containing, peptide-containing and acetylcholinesterase-positive nerves in the cat lower esophagus. Histochem J 26:721-733, 1994
13. Itoh N, Obata K-i, Yanaihara N, Okamoto H: Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature 304:547-549, 1983
14. Couture R, Mizrahi J, Regoli D, Devroede G: Peptides and the human colon: An in vitro pharmacological study. Can J Physiol Pharmacol 59:957-964, 1981
15. Grider JR: Identification of neurotransmitters regulating intestinal peristaltic reflex in humans. Gastroenterology 97:1414-1419, 1989
16. Sonnenberg A, Koch TR: Epidemiology of constipation in the United States. Dis Colon Rectum 32:1-8, 1989
17. Müller-Lissner S: Effect of wheat bran on weight of stool and gastrointestinal transit time: A meta analysis. Br Med J 296:615-617, 1988
18. Bingham SA, Cummings JH: Effect of exercise and physical fitness on large intestinal function. Gastroenterology 97:1389-1399, 1989
19. Kamm MA, Farthing MJG, Lennard-Jones JE: Bowel function and transit rate during the menstrual cycle. Gut 30:605-608, 1989
20. Johanson JF, Sonnenberg A, Koch TR, McCarty DJ: Association of constipation with neurologic diseases. Dig Dis Sci 37:179-186, 1992
21. Koch TR, Carney JA, Go VLW, Szurszewski JH: Inhibitory neuropeptides and intrinsic inhibitory innervation of descending human colon. Dig Dis Sci 36:712-718, 1991
22. Hoyle CHV, Burnstock G, Jass J, Lennard-Jones JE: Enkephalins inhibit non-adrenergic, non-cholinergic neuromuscular transmission in the human colon. Eur J Pharmacol 131:159-160, 1986
23. Bouvier M, Grimaud JC, Naudy B, Salducci J: Effects of morphine on electrical activity of the rectum in man. J Physiol (London) 388:1153-1161, 1987
24. Kantor JL: A clinical study of some common anatomical abnormalities of the colon. I. The redundant colon. Am J Roentgenol 12:414-430, 1924
25. Carney JA, Hayles AB: Alimentary tract manifestations of multiple endocrine neoplasia. type 2b. Mayo Clin Proc 52:543-548, 1477
26. Macedo J FS, Meneghelli UG, Oliveira RB, Godoy RA, Troncon LEA, Dantas RO: Effect of CCK-OP and intraduodenal administration of essential amino acids on intraluminal pressures of sigmoid and rectum in patients with Chagasic megacolon. Dig Dis Sci 31:145-150, 1986
27. Yoshida MM, Krishnamurthy S, Wattchow DA, Furness JB, Schuffler MD: Megacolon in myotonic dystrophy caused by a degenerative neuropathy of the myenteric plexus. Gastroenterology 95:820-827, 1988
28. Koch TR, Schulte-Bockholt A, Telford GL, Otterson MF, Murad TM, Stryker SJ: Acquired megacolon is associated with alteration of vasoactive intestinal peptide levels and acetylcholinesterase activity. Regul Pept 48:309-319, 1993
29. Stadtman ER: Protein oxidation and aging. Science 257:1220-1224, 1992
30. Viani P, Cervato G, Fiorilli A, Cestaro B: Age-related differences in synaptosomal peroxidative damage and membrane properties. J Neurochem 56:253-258, 1991
31. Machlin LJ, Bendich A: Free radical tissue damage: protective role of antioxidant nutrients. FASBB J 1:441-445, 1987
32. Meister A: Glulathione-ascorbic acid antioxidant system in animals. J Biol Chem 269:9397-9400, 1994
33. Martensson J, Jain A, Meister A: Glutathione is required for intestinal function. Proc Natl Acad Sci USA 87:1715-1719, 1990
34. Preston DM, Lennard-Jones JE, Thomas BM: Towards a radiologic definition of idiopathic megacolon. Gastrointest Radiol 10:167-169, 1985
35. Heine JA, Wong WD, Goldberg SM: Collective review: Surgical treatment for constipation. Surg Gyne Obstet 176:403-410, 1993
36. McCready RA, Beart RW Jr: The surgical treatment of incapacitating constipation associated with idiopathic megacolon. Mayo Clin Proc 54:779-783, 1979
37. Koch TR, Carney JA, Go VLW: Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases. Dig Dis Sci 32:369-376, 1987
38. Radomski MW, Palmer RMJ, Moncada S: An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 87:5193-5197, 1990
39. Edelhoch H, Hayaishi O, Teply LJ: The preparation and properties of a soluble diphosphopyridine nucleotide cytochrome c reductase. J Biol Chem 197:97-104, 1952
40. Mahler HR, Sarkar NK, Vernon LP, Alherty RA: Studies on diphosphopyridine nucleotide-cytochrome c reductase: II. Purification and properties. J Biol Chem 199:585-597, 1952
41. Massom L, Lee H, Jarrett HW: Trifiuoperazine binding to porcine brain calmodulin and skeletal muscle tropinin C. Biochemistry 29:671-681, 1990
42. Burleigh DE: N-Nitro-L-arginine reduces nonadrenergic. non-cholinergic relaxations of human gut. Gastroenterology 102:679-683, 1992
43. Dass PD, Bermes EW Jr, Holmes EW: Renal and hepatic output of glutathione in plasma and whole blood. Biochim Biophys Acta 1156:99-102, 1992
44. Lang CA, Naryshkin S, Schneider DL, Mills BJ, Lindeman RD: Low blood glutathione levels in healthy aging adults. J Lab Clin Med 120:720-725, 1992
45. Ballard TC, Farag A, Branum GD, Akwari OE, Opara EC: Effect of L-glutamine supplementation on impaired glucose regulation during intravenous lipid administration. Nutrition 12, 1996 (in press)
46. Johanson JF, Carney JA, Go VLW, Koch TR: Segmental distribution of colonic neuropeptides in Hirschsprung's disease. Regul Pept 36:59-69, 1991
47. Aoki N, et al: Peristaltic reflex and peptidergic nerve control in megacolon. Nippon Heikatsukin Gakkai Zasshi 25:233-235, 1989
48. Cortesini C, Cianchi F, Infantino A, Lise M: Nitric oxide synthase and VIP distribution in enteric nervous system in idiopathic chronic constipation. Dig Dis Sci 40:2450-2455, 1995
49. Feher E, Penzes L: Effect of an antioxidant compound (2-mercaptoethanol) on the nerve terminals of the aging small intestine. Exp Gerontol 25:135-140, 1990
50. Halliwell B: Antioxidants: Sense or speculation? Nutr Today 29(6):15-19, 1994
51. White AC, Thannickal VJ, Fanburg BL: Glutathione deficiency in human disease. J Nutr Biochem 5:218-226, 1994