A study of the luteolytic mechanism of the antiprogesterone RU486 during the late-luteal phase in pseudopregnant rats

Journal of Endocrinology

Volumn 150, Issue 1, 1996, Pages 93-98

  Nakamura, Y ^a   Tamura, H ^a   Ono, M ^a   Shimamura, K ^a   Sugino, N ^a   Numa, F ^a   Ueda, K ^a   Kato, H ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGESTAGEN; MIFEPRISTONE; PROGESTERONE; PROLACTIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ESTRUS CYCLE; FEMALE; LUTEOLYSIS; NONHUMAN; PRIORITY JOURNAL; PSEUDOPREGNANCY; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030055126     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1500093     Document Type: Article

References (27)

1. Arbogast LA & Ben-Jonathan N 1990 The preovulatory prolactin surge is prolonged by a progesterone-dependent dopaminergic mechanism. Endocrinology 126 246-252.
2. Bosc MJ, Germain G, Nicolle A, Mouren M, Philibert D & Baulieu EE 1987 Control of birth in rats by RU 486, an antiprogesterone compound. Journal of Reproduction and Fertility 79 1-8.
3. Concannon PW, Yeager A, Frank D & Iyampillai A 1990 Termination of pregnancy and induction of premature luteolysis by the antiprogestagen, mifepristone, in dogs. Journal of Reproduction and Fertility 88 99-104.
4. Duffy DM, Hess DL & Stouffer RL 1994 Acute administration of a 3β-hydroxysteroid dehydrogenase inhibitor to rhesus monkeys at midluteal phase of the menstrual cycle: evidence for possible autocrine regulation of the primate corpus luteum by progesterone. Journal of Clinical Endocrinology and Metabolism 79 1587-1594.
5. Freeman ME, Smith MS, Nazian SJ & Neill JD 1974 Ovarian and hypothalamic control of the daily surges of prolactin secretion during pseudopregnancy. Endocrinology 94 875-882.
6. Gazal OS, Li Y, Schwabe C & Anderson LL 1993 Attenuation of antepartum relaxin surge and induction of parturition by antiprogesterone RU 486 in sheep. Journal of Reproduction and Fertility 97 233-240.
7. Greenwald GS & Wang MW 1994 Abortifacient effects in the hamster of an antibody to progesterone are reversed by exogenous prolactin. Biology of Reproduction 51 504-508.
8. Hagihara K, Hirata S, Osada T, Hirai M & Kato J 1992 Distribution of cells containing progesterone receptor mRNA in the female rat di- and telencephalon: an in situ hybridization study. Molecular Brain Research 14 239-249.
9. Kato H, Ueda K, Tsutsui H, Miyauchi F & Torigoe T 1982 Role of the nongravid part of the uterus in the regulation of corpus luteum function in pregnant rats. Endocrinology 111 2020-2024.
10. Knickerbocker JJ, Wiltbank MC & Niswender GD 1988 Mechanisms of luteolysis in domestic livestock. Domestic Animal Endocrinology 5 91-107.
11. Li Y, Huang C, Klindt J & Anderson LL 1991a Divergent effects of antiprogesterone, RU 486, on progesterone, relaxin, and prolactin secretion in pregnant and hysterectomized pigs with aging corpora lutea. Endocrinology 129 2907-2914.
12. Li Y, Perezgrovas R, Gazil OS, Schwabe C & Anderson LL 1991b Antiprogesterone, RU 486, facilitates parturition in cattle. Endocrinology 129 765-770.
13. Li Y, Huang C, Klindt J & Anderson LL 1993 Stimulation of prolactin secretion in the pig: central effects of relaxin and the antiprogesterone RU486. Endocrinology 133 1205-1212.
14. 2α concentrations in uteri and plasma of ovariectomized ewes. Journal of Endocrinology 73 427-439.
15. Murphy BD & Rajkumar K 1985 Prolactin as a luteotrophin. Canadian Journal of Physiology and Pharmacology 63 257-264.
16. Park OK & Mayo KE 1991 Transient expression of progesterone receptor messenger RNA in ovarian granulosa cells after the preovulatory luteinizing hormone surge. Molecular Endocrinology 5 967-978.
17. Park-Sarge OK, Parmer TG, Gu Y & Gibori G 1995 Does the rat corpus luteum express the progesterone receptor gene? Endocrinology 136 1537-1543.
18. Pepe GJ & Rothchild I 1974 A comparative study of serum progesterone levels in pregnancy and in various types of pseudopregnancy in the rat. Endocrinology 95 275-279.
19. Rothchild I 1981 The regulation of the mammalian corpus luteum. Recent Progress in Hormone Research 37 183-298.
20. Sánchez-Criado JE, Hernandez G, Bellido C, Gonzalez D, Tébar M, Diaz-Cruz MA & Alonso R 1994 Periovulatory LHRH, LH and FSH secretion in cyclic rats treated with RU486: effects of exogenous LHRH and LHRH antagonist on LH and FSH secretion at early oestrus. Journal of Endocrinology 141 7-14.
21. 3H] ORG.2058, a synthetic progestin, and antibodies to tyrosine hydroxylase in hypothalamus by combined autoradiography and immunocytochemistry. Endocrinology 123 1110-1118.
22. Schreiber JR & Hsueh AJW 1979 Progesterone receptor in rat ovary. Endocrinology 105 915-919.
23. Smith MS, Freeman ME & Neill JD 1975 The control of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat: prolactin, gonadotropin and steroid levels associated with rescue of the corpus luteum of pseudopregnancy. Endocrinology 96 219-226.
24. Sugino N, Shimamura K, Tamura H, Ono M, Nakamura Y, Ogino K & Kato H 1996 Progesterone inhibits superoxide radical production by mononuclear phagocytes in pseudopregnant rats. Endocrinology (In Press).
25. Ueda K, Ochiai K & Rothchild I 1985 A luteotrophic action of prolactin: suppression of intraluteal prostaglandin production or effect? Endocrinology 116 772-778.
26. Uilenbroek JThJ, van der Schoot P, Mattheij JAM & Swarts JJM 1995 Luteolytic and antiluteolytic effect of the antiprogestagen RU486 in pseudopregnant rats. Journal of Endocrinology 145 449-454.
27. Voogt J 1980 Regulation of nocturnal prolactin surges during pregnancy in the rat. Endocrinology 106 1670-1676.