메뉴 건너뛰기




Volumn 67, Issue 2, 1996, Pages 498-507

Characterization of the human protease nexin-1 promoter and its regulation by Sp1 through a G/C-rich activation domain

Author keywords

G C rich elements; Human; Promoter; Protease nexin 1; Serpin; Sp1

Indexed keywords

PROTEASE NEXIN I; REGULATOR PROTEIN; TRANSCRIPTION FACTOR SP1;

EID: 0030054814     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.67020498.x     Document Type: Article
Times cited : (6)

References (45)
  • 1
    • 0026644408 scopus 로고
    • Sp1 DNA binding efficiency is highly reduced in nuclear extract from aged rat tissues
    • Ammendol R., Mesuraca M., Russo T., and Cimino F. (1992) Sp1 DNA binding efficiency is highly reduced in nuclear extract from aged rat tissues. J. Biol. Chem. 267, 17944-17948.
    • (1992) J. Biol. Chem. , vol.267 , pp. 17944-17948
    • Ammendol, R.1    Mesuraca, M.2    Russo, T.3    Cimino, F.4
  • 4
    • 0018932068 scopus 로고
    • Protease-nexin: A cellular component that links thrombin and plasminogen activator and mediates their binding to cells
    • Baker J. B., Low D. A., Simmer R. L., and Cunningham D. D. (1980) Protease-nexin: a cellular component that links thrombin and plasminogen activator and mediates their binding to cells. Cell 21, 37-45.
    • (1980) Cell , vol.21 , pp. 37-45
    • Baker, J.B.1    Low, D.A.2    Simmer, R.L.3    Cunningham, D.D.4
  • 5
    • 0029053384 scopus 로고
    • The gene for the serpin thrombin inhibitor (P17), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes
    • Carter R. E., Cerosaletti K. M., Burkin D. J., Fournier R. E., Jones C., Greenberg B. D., Citron B. A., and Festoff B. W. (1995) The gene for the serpin thrombin inhibitor (P17), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes. Genomics 27, 196-199.
    • (1995) Genomics , vol.27 , pp. 196-199
    • Carter, R.E.1    Cerosaletti, K.M.2    Burkin, D.J.3    Fournier, R.E.4    Jones, C.5    Greenberg, B.D.6    Citron, B.A.7    Festoff, B.W.8
  • 6
    • 0025255579 scopus 로고
    • Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1
    • Cavanaugh K. P., Gurwitz D., Cunningham D. D., and Bradshaw R. A. (1990) Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1. J. Neurochem. 54, 1735-1743.
    • (1990) J. Neurochem. , vol.54 , pp. 1735-1743
    • Cavanaugh, K.P.1    Gurwitz, D.2    Cunningham, D.D.3    Bradshaw, R.A.4
  • 7
    • 0024276524 scopus 로고
    • Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif
    • Courey A. J. and Tjian R. (1988) Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell 55, 887-898.
    • (1988) Cell , vol.55 , pp. 887-898
    • Courey, A.J.1    Tjian, R.2
  • 8
    • 0024811686 scopus 로고
    • Synergistic activation by the glutamine-rich domains of human transcription factor Sp1
    • Courey A. J., Holtzman D. A., Jackson S. P., and Tjian R. (1989) Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell 59, 827-836.
    • (1989) Cell , vol.59 , pp. 827-836
    • Courey, A.J.1    Holtzman, D.A.2    Jackson, S.P.3    Tjian, R.4
  • 9
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam J. D., Lebovitz R. M., and Roeder R. G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489.
    • (1983) Nucleic Acids Res. , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 10
    • 0023659508 scopus 로고
    • Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: Direct participation of c-fos
    • Distel R. J., Ro H. S., Rosen B. S., Groves D. L., and Spiegelman B. M. (1987) Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos. Cell 49, 835-844.
    • (1987) Cell , vol.49 , pp. 835-844
    • Distel, R.J.1    Ro, H.S.2    Rosen, B.S.3    Groves, D.L.4    Spiegelman, B.M.5
  • 11
    • 0021058853 scopus 로고
    • The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter
    • Dynan W. S. and Tjian R. (1983) The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell 35, 79-87.
    • (1983) Cell , vol.35 , pp. 79-87
    • Dynan, W.S.1    Tjian, R.2
  • 12
    • 18344400664 scopus 로고
    • Molecular organization of the rat glia-derived nexin/protease nexin-1 promoter
    • Erno H. and Monard D. (1993) Molecular organization of the rat glia-derived nexin/protease nexin-1 promoter. Gene Expr. 3, 163-174.
    • (1993) Gene Expr. , vol.3 , pp. 163-174
    • Erno, H.1    Monard, D.2
  • 13
    • 0023913120 scopus 로고
    • The steroid and thyroid hormone receptor superfamily
    • Evans R. M. (1988) The steroid and thyroid hormone receptor superfamily. Science 240, 889-895.
    • (1988) Science , vol.240 , pp. 889-895
    • Evans, R.M.1
  • 14
    • 0026508808 scopus 로고
    • Compilation of vertebrate-encoded transcription factors
    • Faisst S. and Meyer S. (1992) Compilation of vertebrate-encoded transcription factors. Nucleic Acids Res. 20, 3-26.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 3-26
    • Faisst, S.1    Meyer, S.2
  • 15
    • 0022768842 scopus 로고
    • Human fibroblasts accelerate the inhibition of thrombin by protease nexin
    • Farrell D. H., Van Nostrand W. E., and Cunningham D. D. (1986) Human fibroblasts accelerate the inhibition of thrombin by protease nexin. Biochem. J. 237, 907-912.
    • (1986) Biochem. J. , vol.237 , pp. 907-912
    • Farrell, D.H.1    Van Nostrand, W.E.2    Cunningham, D.D.3
  • 16
    • 0025877805 scopus 로고
    • Plasminogen activators and inhibitors in the neuromuscular system: III. The serpin protease nexin I is synthesized by muscle and localized at neuromuscular synapses
    • Festoff B. W., Rao J. S., and Hantai D. (1991) Plasminogen activators and inhibitors in the neuromuscular system: III. The serpin protease nexin I is synthesized by muscle and localized at neuromuscular synapses. J. Cell. Physiol. 147, 76-86.
    • (1991) J. Cell. Physiol. , vol.147 , pp. 76-86
    • Festoff, B.W.1    Rao, J.S.2    Hantai, D.3
  • 17
    • 0024465346 scopus 로고
    • Modulation of morphological differentiation of human neuroepithelial cells by serine proteases: Independence from blood coagulation
    • Grand R. J., Grabham P. W., Gallimore M. J., and Gallimore P. H. (1989) Modulation of morphological differentiation of human neuroepithelial cells by serine proteases: independence from blood coagulation. EMBO J. 8, 2209-2215.
    • (1989) EMBO J. , vol.8 , pp. 2209-2215
    • Grand, R.J.1    Grabham, P.W.2    Gallimore, M.J.3    Gallimore, P.H.4
  • 18
    • 0022110035 scopus 로고
    • A glia-derived neurite-promoting factor with protease inhibitory activity
    • Guenther J., Hanspeter N., and Monard D. (1985) A glia-derived neurite-promoting factor with protease inhibitory activity. EMBO J. 4, 1963-1966.
    • (1985) EMBO J. , vol.4 , pp. 1963-1966
    • Guenther, J.1    Hanspeter, N.2    Monard, D.3
  • 19
    • 0011811083 scopus 로고
    • Thrombin modulates and reverses neuroblastoma neurite outgrowth
    • Gurwitz D. and Cunningham D. D. (1988) Thrombin modulates and reverses neuroblastoma neurite outgrowth. Proc. Natl. Acad. Sci. USA 85, 3440-3444.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 3440-3444
    • Gurwitz, D.1    Cunningham, D.D.2
  • 20
    • 0027258961 scopus 로고
    • Protease nexin-1, a thrombin inhibitor, is regulated by interleukin-1 and dexamethasone in normal human fibroblasts
    • Guttridge D. C., Lau A. L., and Cunningham D. D. (1993) Protease nexin-1, a thrombin inhibitor, is regulated by interleukin-1 and dexamethasone in normal human fibroblasts. J. Biol. Chem. 268, 18966-18974.
    • (1993) J. Biol. Chem. , vol.268 , pp. 18966-18974
    • Guttridge, D.C.1    Lau, A.L.2    Cunningham, D.D.3
  • 21
    • 0026763045 scopus 로고
    • The prolonged presence of glia-derived nexin, an endogenous protease inhibitor, in the hippocampus after ischemia-induced delayed neuronal death
    • Hoffmann M. C., Nitsch C., Scotti A. L., Reinhard E., and Monard D. (1992) The prolonged presence of glia-derived nexin, an endogenous protease inhibitor, in the hippocampus after ischemia-induced delayed neuronal death. Neuroscience 49, 397-408.
    • (1992) Neuroscience , vol.49 , pp. 397-408
    • Hoffmann, M.C.1    Nitsch, C.2    Scotti, A.L.3    Reinhard, E.4    Monard, D.5
  • 22
    • 0028800603 scopus 로고
    • A serine protease inhibitor, protease nexin 1, rescues motoneurons from naturally occurring and axotomy-induced cell death
    • Houenou L. J., Turner P. L., Li L., Oppenheim R. W., and Festoff B. W. (1995) A serine protease inhibitor, protease nexin 1, rescues motoneurons from naturally occurring and axotomy-induced cell death. Proc. Natl. Acad. Sci. USA 92, 895-899.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 895-899
    • Houenou, L.J.1    Turner, P.L.2    Li, L.3    Oppenheim, R.W.4    Festoff, B.W.5
  • 23
    • 0024475227 scopus 로고
    • NF-kappa B: A pleiotropic mediator of inducible and tissue-specific gene control
    • Lenardo M. J. and Baltimore D. (1989) NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 58, 227-229.
    • (1989) Cell , vol.58 , pp. 227-229
    • Lenardo, M.J.1    Baltimore, D.2
  • 24
    • 0027379725 scopus 로고
    • Variable and multiple expression of protease nexin-1 during mouse organogenesis and nervous system development
    • Mansuy I. M., van der Putten H., Schmid P., Meins M., Botteri F. M., and Monard D. (1993) Variable and multiple expression of protease nexin-1 during mouse organogenesis and nervous system development. Development 119, 1119-1134.
    • (1993) Development , vol.119 , pp. 1119-1134
    • Mansuy, I.M.1    Van Der Putten, H.2    Schmid, P.3    Meins, M.4    Botteri, F.M.5    Monard, D.6
  • 27
    • 0024404827 scopus 로고
    • Induction of glia-derived nexin after lesion of a peripheral nerve
    • Meier R., Spreyer P., Ortmann R., Harel A., and Monard D. (1989) Induction of glia-derived nexin after lesion of a peripheral nerve. Nature 342, 548-550.
    • (1989) Nature , vol.342 , pp. 548-550
    • Meier, R.1    Spreyer, P.2    Ortmann, R.3    Harel, A.4    Monard, D.5
  • 28
    • 0025967317 scopus 로고
    • Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis
    • Mitchell P. J., Timmons P. M., Hebert J. M., Rigby P. W., and Tjian R. (1991) Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes Dev. 5, 105-119.
    • (1991) Genes Dev. , vol.5 , pp. 105-119
    • Mitchell, P.J.1    Timmons, P.M.2    Hebert, J.M.3    Rigby, P.W.4    Tjian, R.5
  • 29
    • 0025336477 scopus 로고
    • Thrombin and its inhibitors regulate morphological and biochemical differentiation of astrocytes in vitro
    • Nelson R. B. and Simon R. (1990) Thrombin and its inhibitors regulate morphological and biochemical differentiation of astrocytes in vitro. Dev. Brain Res. 54, 93-104.
    • (1990) Dev. Brain Res. , vol.54 , pp. 93-104
    • Nelson, R.B.1    Simon, R.2
  • 30
    • 0026742623 scopus 로고
    • Red 25, a protein that binds specifically to the sterol regulatory region in the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    • Osborne T. F., Bennett M., and Rhee K. (1992) Red 25, a protein that binds specifically to the sterol regulatory region in the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. Biol. Chem. 267, 18973-18982.
    • (1992) J. Biol. Chem. , vol.267 , pp. 18973-18982
    • Osborne, T.F.1    Bennett, M.2    Rhee, K.3
  • 31
    • 0025995937 scopus 로고
    • Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism
    • Pascal E. and Tjian R. (1991) Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism. Genes Dev. 5, 1646-1656.
    • (1991) Genes Dev. , vol.5 , pp. 1646-1656
    • Pascal, E.1    Tjian, R.2
  • 32
    • 0023517177 scopus 로고
    • Thrombin is a potent mitogen for rat astroblasts but not for oligodendrocytes and neuroblasts in primary culture
    • Perraud F., Besnard F., Sensenbrenner M., and Labourdette G. (1987) Thrombin is a potent mitogen for rat astroblasts but not for oligodendrocytes and neuroblasts in primary culture. Int. J. Dev. Neurosci. 5, 181-188.
    • (1987) Int. J. Dev. Neurosci. , vol.5 , pp. 181-188
    • Perraud, F.1    Besnard, F.2    Sensenbrenner, M.3    Labourdette, G.4
  • 33
    • 0025351398 scopus 로고
    • Mechanism of transcriptional activation by Sp1: Evidence for coactivators
    • Pugh B. F. and Tjian R. (1990) Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell 61, 1187-1197.
    • (1990) Cell , vol.61 , pp. 1187-1197
    • Pugh, B.F.1    Tjian, R.2
  • 34
    • 0025137467 scopus 로고
    • An improvement of the single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Puissant C. and Houdebine L. M. (1990) An improvement of the single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Biotechnology 8, 148-149.
    • (1990) Biotechnology , vol.8 , pp. 148-149
    • Puissant, C.1    Houdebine, L.M.2
  • 35
    • 0027976526 scopus 로고
    • Glia-derived nexin/protease nexin-1 is expressed by a subset of neurons in the rat brain
    • Reinhard E., Suidan H. S., Pavlik A., and Monard D. (1994) Glia-derived nexin/protease nexin-1 is expressed by a subset of neurons in the rat brain. J. Neurosci. Res. 37, 256-270.
    • (1994) J. Neurosci. Res. , vol.37 , pp. 256-270
    • Reinhard, E.1    Suidan, H.S.2    Pavlik, A.3    Monard, D.4
  • 36
    • 0023263508 scopus 로고
    • Identification of a protease inhibitor produced by astrocytes that is structurally and functionally homologous to human protease nexin-1
    • Rosenblatt D. E., Cotman C. W., Neito-Sampedro M., Rowe J. W., and Knauer D. J. (1987) Identification of a protease inhibitor produced by astrocytes that is structurally and functionally homologous to human protease nexin-1. Brain Res. 415, 40-48.
    • (1987) Brain Res. , vol.415 , pp. 40-48
    • Rosenblatt, D.E.1    Cotman, C.W.2    Neito-Sampedro, M.3    Rowe, J.W.4    Knauer, D.J.5
  • 37
    • 0028077777 scopus 로고
    • The neurite growth promoting protease nexin 1 in glial cells of the olfactory bulb of the gerbil: An ultrastructural study
    • Scotti A. L., Hoffmann M. C., and Nitsch C. (1994) The neurite growth promoting protease nexin 1 in glial cells of the olfactory bulb of the gerbil: an ultrastructural study. Cell Tissue Res. 278, 409-413.
    • (1994) Cell Tissue Res. , vol.278 , pp. 409-413
    • Scotti, A.L.1    Hoffmann, M.C.2    Nitsch, C.3
  • 38
    • 0024557039 scopus 로고
    • The "initiator" as a transcription control element
    • Smale S. T. and Baltimore D. (1989) The "initiator" as a transcription control element. Cell 57, 103-113.
    • (1989) Cell , vol.57 , pp. 103-113
    • Smale, S.T.1    Baltimore, D.2
  • 39
    • 0029089908 scopus 로고
    • Protease nexin-1 and thrombin modulate neuronal calcium homeostasis and sensitivity to glucose deprivation-induced injury
    • Smith-Swintosky V. L., Zimmer S., Fenton J. W. I., and Mattson M. P. (1995) Protease nexin-1 and thrombin modulate neuronal calcium homeostasis and sensitivity to glucose deprivation-induced injury. J. Neurosci. 15, 5840-5850.
    • (1995) J. Neurosci. , vol.15 , pp. 5840-5850
    • Smith-Swintosky, V.L.1    Zimmer, S.2    Fenton, J.W.I.3    Mattson, M.P.4
  • 40
    • 0023791129 scopus 로고
    • 5′ flanking sequence and genomic structure of Egr-1, a murine mitogen inducible zinc finger encoding gene
    • Tsai-Morris C. H., Cao X. M., and Sukhatme V. P. (1988) 5′ flanking sequence and genomic structure of Egr-1, a murine mitogen inducible zinc finger encoding gene. Nucleic Acids Res. 16, 8835-8846.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 8835-8846
    • Tsai-Morris, C.H.1    Cao, X.M.2    Sukhatme, V.P.3
  • 41
    • 0027468772 scopus 로고
    • Regulation of protease nexin-1 synthesis and secretion in cultured brain cells by injury related factors
    • Vaughan P. J. and Cunningham D. D. (1993) Regulation of protease nexin-1 synthesis and secretion in cultured brain cells by injury related factors. J. Biol. Chem. 268, 3720-3727.
    • (1993) J. Biol. Chem. , vol.268 , pp. 3720-3727
    • Vaughan, P.J.1    Cunningham, D.D.2
  • 42
    • 0028566867 scopus 로고
    • Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease
    • Vaughan P. J., Su J., Cotman C. W., and Cunningham D. D. (1994) Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease. Brain Res. 668, 160-170.
    • (1994) Brain Res. , vol.668 , pp. 160-170
    • Vaughan, P.J.1    Su, J.2    Cotman, C.W.3    Cunningham, D.D.4
  • 43
    • 0029012029 scopus 로고
    • Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults
    • Vaughan P. J., Pike C. J., Cotman C. W., and Cunningham D. D. (1995) Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. J. Neurosci. 15, 5389-5401.
    • (1995) J. Neurosci. , vol.15 , pp. 5389-5401
    • Vaughan, P.J.1    Pike, C.J.2    Cotman, C.W.3    Cunningham, D.D.4
  • 45
    • 0024199329 scopus 로고
    • Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements
    • Williams T., Admon A., Luscher B., and Tjian R. (1988) Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Dev. 2, 1557-1569.
    • (1988) Genes Dev. , vol.2 , pp. 1557-1569
    • Williams, T.1    Admon, A.2    Luscher, B.3    Tjian, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.