Accumulation of the angucycline antibiotic rabelomycin after disruption of an oxygenase gene in the jadomycin B biosynthetic gene cluster of Streptomyces venezuelae

Microbiology

Volumn 142, Issue 1, 1996, Pages 123-132

  Yang, Keqian ^a   Han, Lei ^a,c   Ayer, Stephen W ^b   Vining, Leo C ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Angucycline; Gene disruption; Jadomycin B; Polyketide antibiotic; Streptomyces venezuelae

Indexed keywords

ANGUCYCLINE DERIVATIVE; ANTIBIOTIC AGENT; APRAMYCIN; OXYGENASE; POLYKETIDE; RABELOMYCIN; SYNTHETASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBIOTIC BIOSYNTHESIS; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM CULTURE; BACTERIUM MUTANT; CONTROLLED STUDY; GENE CLUSTER; GENE DISRUPTION; GENETIC SELECTION; GENETIC TRANSFORMATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; SHUTTLE VECTOR; SOUTHERN BLOTTING; STREPTOMYCES;

BACTERIA (MICROORGANISMS); STREPTOMYCES OLIVACEUS; STREPTOMYCES VENEZUELAE;

EID: 0030054143     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/13500872-142-1-123     Document Type: Article

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