Magnitude of benefit from earlier thrombolytic treatment in acute myocardial infarction: New evidence from Grampian region early anistreplase trial (GREAT)

British Medical Journal

Volumn 312, Issue 7025, 1996, Pages 212-215

  Rawles, John ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANISTREPLASE; PLASMINOGEN ACTIVATOR;

ACUTE HEART INFARCTION; ADULT; ARTICLE; BLOOD CLOT LYSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; GENERAL PRACTITIONER; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RURAL AREA; SYMPTOM; TEACHING HOSPITAL; TIME; UNITED KINGDOM;

EID: 0030054086     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.312.7025.212     Document Type: Article

References (17)

1. Weston CFM, Penny WJ, Julian DG on behalf of the British Heart Foundation Working Group. Guidelines for the early management of patients with myocardial infarction. BMJ 1994;308:767-71.
2. The European Myocardial Infarction Project Group. Prehospital thrombolytic therapy in patients with suspected acute myocardial infarction. N Engl J Med 1993;329;383-9.
3. Weaver WD, Cerqueira M, Hallstrom AP, Litwin PE, Martin JS, Kudenchuk PJ, et al for the Myocardial Infarction Triage and Intervention Project Group. Prehospital-initiated vs hospital-initiated thrombolytic therapy. JAMA 1993;270:1211-6.
4. GREAT Group. Feasibility, safety, and efficacy of domiciliary thrombolysis by general practitioners. BMJ 1992;305:548-53.
5. Rawles J on behalf of the GREAT Group. Halving of 1-year mortality from acute myocardial infarction by domiciliary thrombolysis in the Grampian region early anistreplase trial (GREAT). J Am Coll Cardiol 1994;23:1-5.
6. Rawles JM, Haites NE. Patient and general practitioner delays in acute myocardial infarction. BMJ 1988;296:882-4.
7. Rawles JM, Metcalfe MJ, Shirreffs C, Jennings K, Kenmure ACF. Association of patient delay with symptoms, cardiac enzymes, and outcome in acute myocardial infarction. Eur Heart J 1990;11:643-8.
8. Hofgren K, Bondestam E, Johansson G, Jern S, Herlitz J, Holmberg S. Initial pain course and delay to hospital admission in relation to myocardial infarct size. Heart Lung 1988;17:274-80.
9. Maynard C, Althouse R, Olsufka M, Ritchie JL, Davis KB, Kennedy JW. Early versus late hospital arrival for acute myocardial infarction in the western Washington thrombolytic therapy trials. Am J Cardiol 1989;63: 1296-300.
10. Fibrinolytic Therapy Triallists' Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet 1994;343:311-22.
11. Rawles JM. Treatment of myocardial infarction and angina [letter]. BMJ 1995;310:465.
12. Second International Study of Infarct Survival Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 1988;ii:349-60.
13. Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI). Long-term effects of intravenous thrombolysis in acute myocardial infarction: final report of the GISSI study. Lancet 1987;ii:871-4.
14. Wilcox RG, von der Lippe G, Olsson CG, Jensen G, Skene AM, Hampton JR for the Anglo-Scandinavian study of early thrombolysis. Effects of alteplase in acute myocardial infarction: 6-month results from the ASSET study. Lancet 1990;335:1175-8.
15. Hillis WS, Chamberlain DA, de Bono DP, Fox KAA, Murray RG, Julian DG, et al for the AIMS Study Group. Intravenous anistreplase in acute myocardial infarction: continued reduction in mortality up to five years: long-term results of the APSAC international mortality study (AIMS) [abstract]. Br Heart J 1992;68:89.
16. Baigent C, Collins R for the ISIS Collaborative Group. ISIS-2: 4-year mortality follow-up of 17187 patients after fibrinolyric and anti-platelet therapy in suspected acute myocardial infarction [abstract]. Circulation 1993;88(suppl I):I-291.
17. Trent R, Adams J, Jennings K, Rawles J. Impact of resuscitation and thrombolysis on mortality rate from acute myocardial infarction. Int J Cardiol 1995;49:33-7.