New concepts for the development and use of antifolates

Stem Cells

Volumn 14, Issue 1, 1996, Pages 41-46

  Chu, Edward ^a   Grem, Jean L ^a   Johnston, Patrick G ^a   Allegra, Carmen J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Antifolates; Biochemical modulation; Enzyme regulation; immunohistochemistry; Interferon; Monoclonal antibodies; Thymidylate synthase

Indexed keywords

ALPHA INTERFERON; DIHYDROFOLATE REDUCTASE; FLUOROURACIL; FOLIC ACID ANTAGONIST; FOLINIC ACID; IRINOTECAN; MESSENGER RNA; MONOCLONAL ANTIBODY; RALTITREXED; THYMIDYLATE SYNTHASE;

ANTINEOPLASTIC ACTIVITY; AUTOREGULATION; BREAST CANCER; CANCER SURVIVAL; COLON CARCINOMA; COLORECTAL CARCINOMA; DIARRHEA; DRUG DEVELOPMENT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MUCOSA INFLAMMATION; NONHUMAN; PROGNOSIS; PROTEIN RNA BINDING; REVIEW; RNA TRANSLATION; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030053929     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.140041     Document Type: Review

References (20)

1. Grogan L, Sotos GA, Allegra CJ. Leucovorin modulation of fluorouracil. Oncology 1993;7:63-72.
2. Conti JA, Kemeny N, Saltz L et al. Irinotecan (CPT-11) is an active agent in untreated patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 1994;13:195.
3. Cunningham D, Zalcberg J, Francois E et al. Tomudex (ZD1694) a new thymidylate synthase inhibitor with good antitumor activity in advanced colorectal cancer (ACC). Proc Am Soc Clin Oncol 1994;13:199.
4. Washtien WL. Increased levels of thymidylate synthetase in cells exposed to 5-fluorouracil. Mol Pharmacol 1984;25:171-177.
5. Johnston PG, Drake JC, Trepel J et al. The immunological quantitation of thymidylate synthase using the monoclonal antibody TS106 in 5-FU sensitive and resistant human cancer cell lines. Cancer Res 1992;52:4306-4312.
6. Swain SM, Lippman ME, Egan EF et al 5-fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer. J Clin Oncol 1989;7:890-899.
7. Alexander HR, Grem JL, Hamilton JM et al. Thymidylate synthase protein expression is associated with response following neoadjuvant chemotherapy and resection for locally advanced gastric and gastroesophageal adenocarcinoma. Cancer J 1995;1:49-54.
8. Wolmark N, Rockette H, Fisher B et al. The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: results from National Surgical Adjuvant Breast and Bowel Project protocol C-03. J Clin Oncol 1993;11:1879-1887.
9. Spears CP, Shahinian AH, Moran RG et al. In vivo kinetics of thymidylate synthetase inhibition in 5-fluorouracil sensitive and -resistant murine colon adenocarcinomas. Cancer Res 1982;42:450-456.
10. Berne MHO, Gustavsson BG, Almersjo O et al. Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma. Cancer Chemother Pharmacol 1986;16:237-242.
11. Keyomarsi K, Moran RG. Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells. J Biol Chem 1988;263:14402-14409.
12. Chu E, Zinn S, Boarman D et al. The interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line. Cancer Res 1990;50:5834-5840.
13. Chu E, Koeller DM, Johnston PG et al. Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-γ. Mol Pharmacol 1993;43:527-533.
14. Chu E, Koeller DM, Casey JL et al. Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. Proc Natl Acad Sci USA 1991;88:8977-8981.
15. Chu E, Voeller D, Koeller DM et al. Identification of an RNA binding site for human thymidylate synthase. Proc Natl Acad Sci USA 1993;90:517-521.
16. Grem JL, McAtee N, Steinberg S et al. A pilot study of interferon alpha-2a in combination with 5-fluorouracil plus high-dose leucovorin in metastatic gastrointestinal carcinoma. J Clin Oncol 1991;9:1811-1820.
17. Grem JL, Jordan E, Robson ME et al. A phase II study of 5-fluorouracil. leucovorin and interferon α-2a in metastatic colorectal carcinoma. J Clin Oncol 1993;11:1737-1745.
18. Johnston PG, Liang C-M, Henry S et al. The production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissue. Cancer Res 1991;51:6668-6676.
19. Johnston PG, Fisher ER, Rockette HE et al. The role of thymidylate synthase expression in prognosis and outcome to adjuvant chemotherapy in patients with rectal cancer. J Clin Oncol 1994;12:2640-2647.
20. Johnston PG, Lenz HJ, Leichman CG et al. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 1995;55:1407-1412.