Antisense oligodeoxynucleotides selectively suppress expression of the mutant α2(I) collagen allele in type IV osteogenesis imperfecta fibroblasts: A molecular approach to therapeutics of dominant negative disorders

Journal of Clinical Investigation

Volumn 97, Issue 2, 1996, Pages 448-454

  Wang, Qin ^a   Marini, Joan C ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Bone disease; Collagen diseases; Connective tissue; Connective tissue diseases; Gene therapy

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; COLLAGEN TYPE 4; COMPLEMENTARY DNA; MESSENGER RNA; MUTANT PROTEIN;

ALLELE; ARTICLE; COLLAGEN DISEASE; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; DOMINANT INHERITANCE; FIBROBLAST CULTURE; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC DISORDER; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; OSTEOGENESIS IMPERFECTA; PRIORITY JOURNAL;

BASE SEQUENCE; BIOLOGICAL TRANSPORT; CELLS, CULTURED; COLLAGEN; FIBROBLASTS; GENE EXPRESSION REGULATION; GENE THERAPY; GENES, DOMINANT; HUMANS; MICELLES; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES, ANTISENSE; OSTEOGENESIS IMPERFECTA; RNA SPLICING; RNA, MESSENGER; TIME FACTORS;

EID: 0030053744     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118434     Document Type: Article

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