Hypermagnesiuria and hypercalciuria in childhood leukemia: An effect of amikacin therapy

Journal of Pediatric Hematology/Oncology

Volumn 18, Issue 1, 1996, Pages 86-89

  Wu, Binky ^a   Atkinson, Stephanie A ^a   Halton, Jacqueline M ^a   Barr, Ronald D ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Aminoglycoside; Calcium; Children; Leukemia; Magnesium; Renal toxicity

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; VANCOMYCIN;

ADOLESCENT; ADULT; ANTIBIOTIC THERAPY; ARTICLE; CHILD; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; FEMALE; HUMAN; HYPERCALCIURIA; HYPOMAGNESEMIA; INFECTION; MAGNESIUM EXCRETION; MALE; NEPHROTOXICITY; PRIORITY JOURNAL; RISK ASSESSMENT;

ADOLESCENT; AMIKACIN; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; CALCIUM; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; KIDNEY TUBULES, PROXIMAL; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; MAGNESIUM; MALE; NEUTROPENIA; PROSPECTIVE STUDIES;

EID: 0030053531     PISSN: 10774114     EISSN: None     Source Type: Journal    
DOI: 10.1097/00043426-199602000-00017     Document Type: Article

References (29)

1. Atkinson SA, Fraher L, Gundberg CM, et al. Mineral homeostasis and bone mass in children treated for acute lymphoblastic leukemia. J Pediatr 1989;114:793-800.
2. Mendoza SA. Nephrotoxic drugs. Pediatr Nephrol 1988;2:466-76.
3. Durlach J. Secondary magnesium deficits. In: Durlach J, ed. Magnesium in clinical practice. London: John Libbey, 1988:111-94.
4. Elliot WC, Patchin DS. Aminoglycoside-mediated calciuresis. J Pharmacol Exp Ther 1992;262:151-6.
5. Foster JE, Harpur ES, Garland HO. An investigation of the acute effect of gentamicin on the renal handling of electrolytes in the rat. J Pharmacol Exp Ther 1992;261:38-43.
6. Bar RS, Wilson HE, Mazzaferri EL. Hypomagnesemic hypocalcemia secondary to renal magnesium wasting: a possible consequence of high dose gentamicin therapy. Ann Intern Med 1975;82:646-9.
7. Kelnar CJH, Toar WS, Reynolds DJ, et al. Hypomagnesemic hypocalcemia with hypokalemia caused by treatment with high dose gentamicin. Arch Dis Child 1978;53:817-20.
8. Mountokalakis T, Tzouvelekis E, Mayopoulou-Symvoulidou D. Effects of gentamicin on renal magnesium excretion. In: Halpern MF, Durlach J, eds. Magnesium deficiency: physiopathology and treatment implications. Basel: Karger, 1985:172-4.
9. Davey P, Gozzard D, Goodall M, et al. Hypomagnesaemia: an underdiagnosed interaction between gentamicin and cytotoxic chemotherapy for acute non-lymphoblastic leukaemia. J Antimicrob Chemother 1985;15:623-8.
10. Barr RD, DeVeber LL, Pai KM, et al. Management of children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols. Am J Pediatr Hematol Oncol 1992;14:136-9.
11. MacIntyre I. Flame photometry. Adv Clin Chem 1961;4:1-28.
12. Fiske CH, Subbarow Y. Colorimetric determination of phosphorus. J Biol Chem 1925;66:375-400.
13. Meites S. In: Pediatric clinical chemistry: a survey of reference (normal) values, methods and instrumentation, with commentary, ed 2. Washington, DC: American Association for Clinical Chemistry, 1981:69.
14. Ghazali S, Barratt TM. Urinary excretion of calcium and magnesium in children. Arch Dis Child 1975;49:97-101.
15. Mabry CC, Tietz NW. Reference ranges for laboratory tests. In: Nelsen WE, ed. Textbook of pediatrics. Philadelphia: WB Saunders, 1983:1827-52.
16. Shah GM, Kirschenbaum MA. Renal magnesium wasting associated with therapeutic agents. Miner Electrolyte Metab 1991;17:58-64.
17. Piscator M. Markers of tubular dysfunction. Toxicol Lett 1989;46:197-204.
18. Shenlag JJ, Sulfin TA, Plaut ME. Early detection of aminoglycoside nephrotoxicity with urinary β2-microglobulin. J Med 1978;9:201-10.
19. Dirks JH, Wong NLM. Renal magnesium wasting disorders. Adv Exp Med Biol 1982;208:193-7.
20. Quamme GA, Dirks JH. The physiology of renal magnesium handling. Renal Physiol 1986;9:257-69.
21. Lukert BP, Raisz LG. Glucocorticoid-induced osteoporosis: pathogenesis and management. Ann Intern Med 1990;112:352-64.
22. Suzuki Y, Ichikawa Y, Saito E, et al. Importance of increased urinary calcium excretion in the development of secondary hyperparathyroidism of patients under glucocorticoid therapy. Metabolism 1983;32:151-6.
23. Bradley C. Investigations of hypomagnesemia in childhood leukemia and the development of new stable isotope techniques to determine magnesium absorption [MSc. Thesis]. Hamilton, Ontario: McMaster University, 1992.
24. Bertino JS, Booker LA, Franck PA, et al. Incidence of and significant risk factors for aminoglycoside-associated nephrotoxicity in patients dosed by using individualized pharmacokinetic monitoring. J Infect Dis 1991;163:173-9.
25. Haughey DB, Hilligos DM, Grassi S, et al. Two compartment gentamicin pharmacokinetics in premature neonates: a comparison to adults with decreased glomerular filtration rates. J Pediatr 1980;96:325-30.
26. McCracken GH Jr. Aminoglycoside toxicity in infants and children. Am J Med 1986;80:172-8.
27. Chandrasekar PH, Cronin SM. Nephrotoxicity in bone marrow transplant recipients receiving aminoglycoside plus cyclosporin or aminoglycoside alone. J Antimicrob Chemother 1991;27:845-9.
28. Hesseling PB, Mouton WL, Henning PA, et al. A prospective study of long term use of amikacin in a pediatrics department. Indications, administration, side-effects, bacterial isolates and resistance. S Afr Med J 1990;78:192-5.
29. Kramer WG, Cleary T, Frankel LS. Multiple-dose amikacin kinetics in pediatric oncology patients. Clin Pharmacol Ther 1979;26:635-40.