Evidence for specific involvement of 5-HT1A and 5-HT2A/C receptors in the expression of patterns of spontaneous motor activity of the rat

European Journal of Pharmacology

Volumn 295, Issue 2-3, 1996, Pages 155-161

  Hillegaart, Viveka ^b   Estival, Alain ^a,b   Ahlenius, Sven ^b  

^a School of Pharmacy   (France)

^b Astra Arcus AB   (Sweden)

Author keywords

(Rat); 5 HT receptor; Locomotor activity; Stereotyped behavior

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETAXOLOL; PINDOLOL; RITANSERIN; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 1B ANTAGONIST; SEROTONIN 1C RECEPTOR; SEROTONIN 2A AGONIST; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2C AGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG SELECTIVITY; DRUG SPECIFICITY; LOCOMOTION; MALE; MOTOR ACTIVITY; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; RAT; SEROTONINERGIC TRANSMISSION; STEREOTYPY; SUBCUTANEOUS DRUG ADMINISTRATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; BEHAVIOR, ANIMAL; BETAXOLOL; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN;

EID: 0030053186     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00666-4     Document Type: Article

References (28)

1. Ahlenius, S. and K. Larsson, 1985, Antagonism by lisuride and 8-OH-DPAT of 5-HTP-induced prolongation of the performance of male rat sexual behavior, Eur. J. Pharmacol. 110, 379.
2. Ahlenius, S. and K. Larsson, 1991, Opposite effects of 5-methoxy-N-N-di-methyltryptamine and 5-hydroxytryptophan on male rat sexual behavior, Pharmacol. Biochem. Behav. 38, 201.
3. 1A receptor agonists flesinoxan and 8-OH-DPAT in the rat, Eur. J. Pharmacol. 200, 259.
4. 1A agonists on patterns of rat motor activity in relation to effects on forebrain monoamine synthesis, Pharmacol. Toxicol. 72, 398.
5. 2A receptors, Eur. J. Pharmacol. 261, 285.
6. Artigas, F., 1993, 5-HT and antidepressants: new views from microdialysis studies, Trends Pharmacol. Sci. 14, 262.
7. Bedard, P., A. Carlsson and M. Lindqvist, 1972, Effect of a transverse cerebral hemisection on 5-hydroxytryptamine metabolism in the rat brain. Naunyn-Schmied. Arch. Pharmacol. 272, 1.
8. Carlsson, A. and M. Lindqvist, 1972, The effect of L-tryptophan and some psychotropic drugs on formation of 5-hydroxytryptophan in the mouse brain in vivo, J. Neural Transm. 33, 23.
9. 1-Adrenoceptor Antagonists (LERS Monogr. Ser., Vol. 1), eds. P.L. Morselli, J.R. Kilborn, I. Cavero, D.C. Harrison and S.Z. Langer (Raven Press, New York) p. 31.
10. Costain, D.W. and A.R. Green, 1978, β-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine, Br. J. Pharmacol. 64, 193.
11. Ericson, E., J. Samuelsson and S. Ahlenius, 1991, Photocell measurements of rat motor activity: a contribution to sensitivity and variation in behavioral observations, J. Pharmacol. Methods 25, 111.
12. Evenden, J.L. and K. Ängeby-Möller, 1990, Effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on locomotor activity and rearing of mice and rats, Psychopharmacology 102, 485.
13. 2 receptors, Br. J. Pharmacol. 84, 743.
14. Hillegaart, V., M.-L. Wadenberg and S. Ahlenius, 1989, Effects of 8-OH-DPAT on motor activity in the rat, Pharmacol. Biochem. Behav. 32, 797.
15. 1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo: a microdialysis study, J. Neurochem. 60, 776.
16. Hjorth, S., A. Carlsson, P. Lindberg, D. Sanchez, H. Wikström, L.-E. Arvidsson, U. Hacksell and J.L.G. Nilsson, 1982, 8-Hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent an selective simplified ergot congener with central 5-HT-receptor stimulating activity, J. Neural Transm. 55, 169.
17. Hoyer, D., D.E. Clarke, J.R. Fozard, P.R. Hartig, G.R. Martin, E.J. Mylecharane, P.R. Saxena and P.A. Humphrey, 1994, VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin), Pharmacol. Rev. 46, 157.
18. Invernizzi, R., S. Belli and R. Samanin, 1992, Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex, Brain Res. 584, 322.
19. 1A receptors in the mediation of exploratory locomotor activity in the rat, J. Psychopharmacol. 3, 32.
20. 1A receptor agonists, Eur. J. Pharmacol. 173, 121.
21. Kalkman, H.O. and J. Soar, 1990, Determination of the 5-HT receptor subtype involved in 8-OH-DPAT-induced hyperlocomotion - Potential difficulties arising from inadequate pharmacological tools, Eur. J. Pharmacol. 191, 383.
22. 2 receptor antagonist amperozide attenuates 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane-induced inhibition of male rat sexual behavior, Eur. J. Pharmacol. 212, 241.
23. 2 antagonist, Mol. Pharmacol. 27, 600.
24. 1A agonists on locomotor and investigatory behaviors in rats differ from those of hallucinogens, Psychopharmacology 98, 321.
25. 2 binding properties of derivatives of the hallucinogen 1-(2,5-dimethoxy-phenyl)-2-aminopropane (2,5-DMA), Eur. J. Pharmacol. 102, 23.
26. 1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat, Eur. J. Pharmacol. 106, 271.
27. Winer, B.J., 1971, Statistical Principles in Experimental Design (McGraw-Hill, New York).
28. Yocca, F.D., R.N. Wright, R.R. Margraf and M.S. Eison, 1990, 8-OH-DPAT and buspirone analogs inhibit the ketanserin-sensitive quipazine-induced head shake response in rats, Pharmacol. Biochem. Behav. 35, 251.