Metal-chelating inhibitors of a zinc finger protein HIV-EP1. Remarkable potentiation of inhibitory activity by introduction of SH groups

Journal of Medicinal Chemistry

Volumn 39, Issue 2, 1996, Pages 503-507

  Fujita, Mikako ^a   Otsuka, Masami ^a   Sugiura, Yukio ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (DIMETHYLAMINO) 2,6 BIS[[(2 MERCAPTOETHYL)AMINO]METHYL]PYRIDINE; CHELATING AGENT; DITHIOTHREITOL; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MERCAPTAMINE; METAL CHELATE; PROTEIN INHIBITOR; PYRIDINE DERIVATIVE; THIOL GROUP; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ARTICLE; CHELATION; DRUG POTENCY; DRUG SYNTHESIS; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; METAL BINDING; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROVIRUS; SIGNAL TRANSDUCTION; VIRUS INTERFERENCE;

ANIMALS; BASE SEQUENCE; CHELATING AGENTS; DNA; DNA-BINDING PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NF-KAPPA B; SULFHYDRYL COMPOUNDS; TRANSCRIPTION FACTORS; ZINC; ZINC FINGERS;

EID: 0030052885     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950831t     Document Type: Article

References (21)

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17. Reduction of 17 or 19 with 3 equiv of DTT proceeded immediately and completely to afford 2. Similarly, 18 or 20 gave 3.
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