Chemosensitization and drug accumulation assays as complementary methods for the screening of multidrug resistance reversal agents

Cancer Letters

Volumn 99, Issue 1, 1996, Pages 109-114

  Quesada, A R ^a   Barbacid, M M ^a   Mira, E ^a,b   Aracil, M ^a   Marquez G ^a  

^a Research Center   (Spain)

^b UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

Chemosensitization; Multidrug resistance; PSC 833; Resistance modifier agent; Rhodamine 123; Verapamil

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOSPORIN DERIVATIVE; DOXORUBICIN; RHODAMINE 123; VALSPODAR; VERAPAMIL;

ANIMAL CELL; ARTICLE; CELL LINE; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG SCREENING; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0030052628     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(95)04044-7     Document Type: Article

References (23)

1. Biedler, J.L. (1994) drug resistance: genotype versus phenotype. Thirty-second G.H.A. Clowes Memorial Award Lecture. Cancer Res., 54, 666-678.
2. Biedler, J.L., Chang, T., Druskin, H., Meyers, M.B. and Spengler, B.A. (1993) Modulation of multidrug resistance gene expression by chemosensitizing agents. Proc. Am. Assoc. Cancer Res., 34, 578.
3. Boer, R., Haas, S. and Schödl, A. (1994) Influence of dexniguldipine-HCl on Rhodamine 123 accumulation in a multidrug-resistam leukaemia cell line: comparison with other chemosensitisers. Eur. J. Cancer, 30A, 1117-1123.
4. Boesch, D., Gaveriaux, C. and Jachez, B. (1991) In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833. Cancer Res., 51, 4226-4233.
5. Gottesman, M.M. and Pastan, I. (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem., 62, 385-427.
6. Grandi, M., Geroni, C. and Giuliani, F.C. (1986) Isolation and characterization of a human colon adenocarcinoma cell line resistant to doxorubicin. Br. J. Cancer, 54, 515-518.
7. Grandi, M., Young, C. and Bellini, O. (1987) Pleiotropic multidrug resistant LoVo, P388 and Y-407 cell lines have an increased tubulovesicular compartment. Proc. Am. Assoc. Cancer Res., 28, 279.
8. Hill, B.T. (1990) Modulation of antitumour drug resistance: experimental laboratory data and results of clinical evaluation. Cancer Treat. Rev., 17, 197-202.
9. Homolya, L., Holló, Z., Germann, U.A., Pastan, I., Gottesman, M.M. and Sarkadi, B. (1993) Fluorescent cellular indicators are extruded by the multidrug resistance protein. J. Biol. Chem., 268, 21493-21496 .
10. Johnson, L.V., Walsh, M.L., Bockus, B.J. and Chen LB. (1981) Monitoring of relative mitochondrial potential in living cells by fluorescence microscopy. J. Cell Biol., 88, 526-35.
11. Kellen, J.A. (1993) The reversal of multidrug resistance in cancer. Anticancer Res., 13, 959-961.
12. Kessel, D., Beck, W.T., Kukurunga, D. and Schulz, V. (1991) Characterization of multidrug resistance by fluorescent dyes. Cancer Res., 51, 4665-4670.
13. Loor, F., Boesch, D., Gaveriaux, C., Jachez, B., Pourtier-Manzanedo, A. and Emmer, G. (1992) SDZ 280-446, a novel semi-synthetic cyclopeptolide: in vitro and in vivo circumvention of the P-glycoprotein mediated tumour cell multidrug resistance. Br. J. Cancer, 65, 11-18.
14. Maynadie, M., Lizard, G., Solary, E., Roignot, P. and Carli, P.M. (1994) Multidrug resistance phenotype evaluation by immunofluorescence and functional tests: comparison of two monoclonal antibodies and three fluorescent dyes in three cells lines. Anticancer Res., 14, 2605-2610.
15. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63.
16. Neyfakh, A.A. (1988) Use of fluorescent dyes as molecular probes for the study of multidrug resistance. Exp. Cell Res., 174, 168-176.
17. Patel, N.H. and Rothenberg, M.L. (1994) Multidrug resistance in cancer chemotherapy. Invest. New Drug, 12, 1-13.
18. Pourtier-Manzanedo, A., Didler, A.D., Muller, C.D. and Loor, F. (1993) SDZ PSC 833 and SDZ 280-446 are the most active of various resistance-modifying agents in restoring rhodamine 123 retention within multidrug resistant P388 cells. Anti-Cancer Drugs, 3, 419-421.
19. Tapiero, H., Munck, J.N., Fourcade, A. and Lampidis, T.J. (1984) Cross-resistance to rhodamine 123 in adriamycin and daunorubicin-resistant friend leukemia cell variants. Cancer Res., 44, 5544-5549.
20. Tsuruo, T., Iida, H., Tsukagoshi, S. and Sakurai, J. (1981) Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res., 41, 1967-1972.
21. Twentyman, P.R. and Bleehen, N.M. (1991) Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin A. Eur. J. Cancer, 27, 1639-1642.
22. Twentyman, P.R., Rhodes, T. and Rayner, S. (1994) A comparison of Rhodamine 123 accumulation and efflux in cells with P-glycoprotein-mediated and MRP-associated multidrug resistance phenotypes. Eur. J. Cancer, 30A, 1360-1369.
23. Yoshimura, A., Shudo, N., Ikeda, S.I., Sumizawa, T. and Akiyama, S.I. (1990) Novel screening method for agents that overcome classical multidrug resistance in a human cell line. Cancer Lett., 50, 45-51.