Sites of urokinase-type plasminogen activator expression and distribution of its receptor in the normal human kidney

Histochemistry and Cell Biology

Volumn 105, Issue 1, 1996, Pages 53-60

  Wagner, S N ^a,c   Atkinson, M J ^a   Wagner, C ^a   Hofler H ^a,b   Schmitt, M ^b   Wilhelm, O ^b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PLASMINOGEN ACTIVATOR; UROKINASE;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY TUBULE; PRIORITY JOURNAL;

HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; KIDNEY; KIDNEY NEOPLASMS; RECEPTORS, CELL SURFACE; RNA, MESSENGER; TISSUE DISTRIBUTION; URINARY PLASMINOGEN ACTIVATOR;

EID: 0030052005     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01450878     Document Type: Article

References (35)

1. Altus MS, Pearson D, Horiuchi A, Nagamine Y (1987) Inhibition of protein synthesis in LLC-PK, cells increases calcitonin-induced plasminogen-activator gene transcription and mRNA stability. Biochem J 242:387-392
2. Baker MS, Bleakley P, Woodrow GC, Doe WF (1990) Inhibition of cancer cell urokinase plasminogen activator by its specific inhibitor PAI-2 and subsequent effects on extracellular matrix degradation. Cancer Res 50:4676-4684
3. Bukovsky A, Labarrere CA, Carter C, Haag B, Faulk WP (1992) Novel immunohistochemical markers of human renal allograft dysfunction-antithrombin III, Thy-1, urokinase, and alpha-smooth muscle actin. Transplantation 54:1064-1071
4. Chucholowski N, Schmitt M, Rettenberger P, Schüren E, Moniwa N, Goretzki L, Wilhelm O, Weidle U, Jänicke F, Graeff H (1992) Flow-cytometric analysis of the urokinase-receptor (uPAR) on tumor cells by fluorescent uPA-ligand or monoclonal antibody #3936. Fibrinolysis 6 [Suppl #4]:95-102
5. Danø K, Andreasen PA, Grøndahl-Hansen J, Kristensen P, Nielsen LS, Skriver L (1985) Plasminogen activators, tissue degradation and cancer. Adv Cancer Res 44:139-266
6. Glass WF, Kreisberg JI, Troyer DA (1993) Two-chain urokinase, receptor, and type 1 inhibitor in cultured human mesangial cells. Am J Physiol 264(3Pt2):F532-F539
7. Hart DA, Rehetmulla A, Babins E (1986) Species differences in the detection of high molecular weight urinary plasminogen activators. Comp Biochem Physiol 84B:287-293
8. Hasui Y, Suzumiya J, Sumiyoshi A, Hashida S, Ishikawa E (1988) Distribution of plasminogen activators in human kidney and male genital organs using a highly sensitive enzyme immunoassay. Thromb Res 51:453-459
9. Hata M (1989) The study of plasminogen activator in renal cell carcinoma with special remarks on urokinase type plasminogen activator. Nippon Hinyokika Gakkai Zasshi 80:1558-1565
10. Hearing VJ, Law LW, Corti A, Appella E, Blasi F (1988) Modulation of metastatic potential by cell surface urokinase of murine melanoma cells. Cancer Res 48:1270-1278
11. Höfler H, Childers H, Montminy MR, Lechan RM, Goodman RH, Wolfe HJ (1986) In situ hybridization methods for the detection of somatostatin mRNA in tissue sections using antisense RNA probes. Histochem J 18:597-604
12. Hollas W, Blasi F, Boyd D (1991) Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer. Cancer Res 51:3690-3695
13. Huber K, Kirchheimer J, Binder R (1982) Rapid isolation and characterization of high molecular weight urokinase from native human urine. Thromb Haemost 47:197-202
14. Iwamoto T, Nakashima Y, Sueishi K (1990) Secretion of plasminogen activator and its inhibitor by glomerular epithelial cells. Kidney Int 37:1466-1476
15. Kirchheimer JC, Pflüger H, Hienert G, Binder BR (1985) Increased urokinase activity to antigen ratio in human renal-cell carcinoma. Int J Cancer 35:737-741
16. Kristensen P, Eriksen J, Danø K (1991) Localization of urokinase-type plasminogen activator messenger RNA in the normal mouse by in situ hybridization. J Histochem Cytochem 39:341-349
17. Langer DJ, Kuo A, Kariko K, Ahuja M, Klugherz BD, Ivanics KM, Hoxie JA, Williams WV, Liang BT, Cines DB, Barnathan ES (1993) Regulation of the endothelial cell urokinase-type plasminogen activator receptor. Circ Res 72:330-340
18. Larsson L-I, Skriver L, Nielsen LS, Grøndahl-Hansen J, Kristensen P, Danø K (1984) Distribution of urokinase-type plasminogen activator immunoreactivity in the mouse. J Cell Biol 98:894-903
19. Mignatti P, Robbins E, Rifkin DB (1986) Tumor invasion through the human amniotic membrane: requirement for a proteinase cascade. Cell 47:487-498
20. Müllbacher W, Maier M, Binder BR (1989) Regulation of plasminogen activation in isolated perfused rat kidney. Am J Physiol 256:F787-F793
21. Ossowski L (1988) In vivo invasion of modified chorioallantoic membrane by tumor cells: the role of cell surface-bound urokinase. J Cell Biol 107:2437-2445
22. Ossowski L, Clunie G, Masucci M-T, Blasi F (1991) In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion. J Cell Biol 115:1107-1112
23. Pepper MS, Matsumoto K, Nakamura T, Orci L, Montesano R (1992) Hepatocyte growth factor increases urokinase-type plasminogen activator (u-PA) and u-PA receptor expression in Madin-Darby canine kidney epithelial cells. J Biol Chem 267:20493-20496
24. Quax PHA, Pedersen N, Masucci MT, Weening-Verhoeff EJD, Danø K, Verheijen JH, Blasi F (1991) Complementation between urokinase-producing and receptor-producing cells in extracellular matrix degradation. Cell Regulation 2:793-803
25. Rømer J, Lund LR, Eriksen J, Ralfkiær E, Zeheb R, Gelehrter TD, Danø K, Kristensen P (1991) Differential expression of urokinase-type plasminogen activator and its type-1 inhibitor during wound healing of mouse skin wounds. J Invest Dermatol 97:803-811
26. Rondeau E, Ochi S, Lacave R, He C-J, Medcalf R, Delarue F, Sraer JD (1989) Urokinase synthesis and binding by glomerular epithelial cells in culture. Kidney Int 36:593-600
27. Saksela O, Holthöfer H (1987) Plasminogen activators during differentiation of the human kidney. Differentiation 34:131-138
28. Sappino A-P, Huarte J, Belin D, Vassalli J-D (1989) Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos. J Cell Biol 109:2471-2479
29. Sappino A-P, Huarte J, Vassalli J-D, Belin D (1991) Sites of synthesis of urokinase and tissue-type plasminogen activators in the murine kidney. J Clin Invest 87:962-970
30. Schenk EA, Schwartz RH, Lewis RA (1971) Tamm-Horsfall mutoprotein. I. Localization in the kidney. Lab Invest 25:92-95
31. Schmitt M, Chucholowski N, Busch E, Hellmann D, Wagner B, Goretzki L, Jänicke F, Günzler WA, Graeff H (1991) Fluorescent probes as tools to assess the receptor for the urokinase-type plasminogen activator (uPA) on tumor cells. Semin Thromb Hemost 17:291-302
32. Sumi Y, Dent MAR, Owen DE, Seeley PJ, Morris RJ (1992) The expression of tissue and urokinase-type plasminogen activators in neural development suggests different modes of proteolytic involvement in neuronal growth. Development 116:625-637
33. Takada A, Sakakibara K, Nagase M, Shizume K, Takada Y (1986) Determination of urokinase in the urine of healthy volunteers and patients with renal diseases. Thromb Res 44:867-873
34. Wojta J, Hoover RL, Daniel TO (1989) Vascular origin determines plasminogen activator expression in human endothelial cells. J Biol Chem 264:2846-2852
35. 2+ potentiates cAMP-dependent expression of urokinase-type plasminogen activator gene through a calmodulin- and protein kinase C-independent mechanism. J Biol Chem 265:21194-21201