Loss and shedding of surface markers from the leukemic myeloid monocytic line THP-1 induced to undergo apoptosis

Journal of Cellular Biochemistry

Volumn 60, Issue 2, 1996, Pages 246-259

  Brown, S B ^a,b   Kluck, R M ^a   Ellem, K A O ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b Liver Unit   (United Kingdom)

Author keywords

aminopeptidase N shedding; apoptosis; CD13; CD14; CD33; ectopeptidase activation; ethanol THP 1 cultures

Indexed keywords

ALCOHOL; CD14 ANTIGEN; CD33 ANTIGEN; CELL SURFACE MARKER; DNA FRAGMENT; HOE 33342; MICROSOMAL AMINOPEPTIDASE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PEPTIDASE; PROTEINASE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVATION; ENZYME ASSAY; FLUORESCENCE ACTIVATED CELL SORTER; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MICROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY; VITAL STAIN;

AMINO ACID SEQUENCE; ANTIGENS, CD13; ANTIGENS, SURFACE; APOPTOSIS; CELL SEPARATION; CULTURE MEDIA; ETHANOL; FLOW CYTOMETRY; HUMANS; LEUKEMIA, MYELOID; MONOCYTES; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; TUMOR STEM CELLS;

EID: 0030051438     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19960201)60:2<246::AID-JCB9>3.0.CO;2-X     Document Type: Article

References (44)

1. Bažil V, Strominger JL (1994): Metalloprotease and serine protease are involved in cleavage of CD43, CD44, and CD16 from stimulated human granulocytes. J Immunol 152:1314-1333.
2. Brown SB, Krause D, Townsend E, Ellem KAO (1992): Development of a sensitive peptidase assay: in search of cell associated proteases responsible for the cleavage of preproTGFα. J Cell Biochem 48:411-423.
3. Brown SB, Krause D, Ellem KAO (1993): Low fluences of ultraviolet irradiation stimulate HeLa cell surface amino-peptidase and candidate "TGFαase" activity. J Cell Biochem 51:102-115.
4. Brown SB, Kluck RM, Ellem KAO (1994): Induction of cell surface peptidase activity: A global response to cell stress correlated with apoptosis. J Cell Biochem 54:320-331.
5. Cappelluti E, Strom SC, Harris RB (1993): Potential role of two novel elastase-like enzymes in processing pro-transforming growth factor-α. Biochemistry 32:551-560.
6. Chen TR (1977): In situ detection of Mycoplosma contamination in cell cultures by fluorescent Hoechst 33258 stain. Exp Cell Res 104:255-262.
7. Chenevix-trench G, Cullinan M, Ellem KAO (1992): UV induction of transforming growth factor alpha in melanoma cell lines is a posttranslational event. J Cell Physiol 152:328-336.
8. Choudry Y, Kenny AJ (1991): Hydrolysis of transforming growth factor-α by cell surface peptidases in vitro. Biochem J 280:57-60.
9. Cohen GM, Sun X-M, Feamhead H, MacFarlane M, Brown DG, Snowden RT, Dinsdale D (1994): Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes. J Immunol 153:507-516.
10. Cohen GM, Sun X-M, Snowden RT, Ormerod MG, Dinsdale D (1993): Identification of a transitional preapoptotic population of thymocytes. J Immunol 151:566-574.
11. Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, MA, Lassota P, Traganos F (1992): Features of apoptotic cells measured by flow cytometry Cytometry 13:795-808.
12. Dransfield I, Buckle AM, Savill JS, McDowall A, Haslett C, Hogg N (1994): Neutrophil apoptosis is associated with a reduction in CD16 (FcγrIII) expression. J Immunol 153: 1254-1263.
13. Duvall E, Wyllie H, Morris RG (1985): Macrophage recognition of cells undergoing programmed cell death (apoptosis). Immunology 56:351-358.
14. Ehlers MRW, Riordan JF (1991): Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins. Biochemistry 30:10065-1074.
15. Ellem KAO, Cullinan M, Baumann KC, Dunstan A (1988): UVR induction of TGF-alpha. A possible autocrine mechanism for the epidermal melanocytic response and for promotion of epidermal carcinogenesis. Carcinogenesis 9:797-801.
16. Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM (1992a): Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 148:2207-2216.
17. Fadok VA, Savill JS, Haslett C, Bratton DL, Doherty DE, Campbell PA, Henson PM (1992b): Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J Immunol 149:4029-4035.
18. Harano T, Mizuno K (1994): Phorbol ester-induced activation of a membrane-bound candidate pro-transforming growth factor-α processing enzyme. J Biol Chem 269: 20305-20311.
19. Harmon BV, Corder AM, Collins RJ, Gobe GC, Allen J, Allan DJ, Kerr JFR (1990): Cell death induced in a murine mastocytoma by 42-47°C heating in vitro: Evidence that the form of death changes from apoptosis to necrosis above a critical heat load. Int J Radiat Biol 58:845-858.
20. Harrison D, Phillips JH, Lanier LL (1991): Involvement of a metaloprotease in spontaneous and phorbol ester-induced release of natural killer cell-associated FCγRIII. J Immunol 147:3459-3465.
21. Ignotz RA, Kelly B, Davis RJ, Massagué J (1986): Biologically active precursor for transforming growth factor type a, released by retrovirally transformed cells. Proc Natl Acad Sci 83:6307-6311.
22. Kenny AJ, O'Hare MJ, Gusterson BA (1989): Cell-surface peptidases as modulators of growth and differentiation. Lancet 12:785-787.
23. Kerr JFR, Wyllie AH, Currie AR (1972): Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257.
24. Kerr JFR, Gobe GC, Winterford CM, Harmon BV (1995): Anatomical methods in cell death. Methods Cell Biol 64:1-27.
25. Kluck RM, Chapman DE, Egan M, McDougall CA, Harmon BV, Moss DJ, Kerr JFR, Halliday JW (1993): Spontaneous apoptosis in NS-1 myeloma cultures: Effects of cell density, conditioned medium and acid pH. Immunobiology 188:124-133.
26. Lennon SV, Martin SJ, Cotter TG (1991): Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli. Cell Prolif 24:203-214.
27. Louvard D, Maroux S, Vannier CH, Desnuelle P (1975): Topological studies on the hydrolases to the intestinal brush border membrane. Biochim Biophys Acta 375:236-248.
28. Massagué J (1990): Transforming growth factor-α. J Biol Chem 265 21393-21396.
29. Massagué J, Pandiella A (1993): Membrane-anchored growth factors. Annu Rev Biochem 62:515-541.
30. Menrad A, Speicher D, Wacker J, Herlyn M (1993): Biochemical and functional characterization of aminopeptidase-N expressed by human melanoma cells. Cancer Res 53:1450-1455.
31. Mueller SG, Paterson AJ, Kudlow JE (1990): Transforming growth factor α in arterioles: Cell surface processing of its precursor by elastases. Mol Cell Biol 10:4596-4602.
32. Oberhammer F, Wilson JW, Dive C, Morris ID, Hickman JA, Wakeling AE, Walker PR, Sikorska M (1993): Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 12:3679-3684
33. Ormerod MG, Sun X-M, Snowden RT, Davies R, Fearnhead H, Cohen GM (1993): Increased membrane permeability of apoptotic thymocytes: A flow cytometric study. Cytometry 14:595-602.
34. Pandiella A, Bosenberg MW, Huang EJ, Besmer P, Massagué J (1992): Cleavage of membrane-anchored growth factors involves distinct protease activities regulated through common mechanisms. J Biol Chem 267:24028-20433.
35. +-dependent amino acid transport in bovine renal brush-border membranes. Biochem J 290:59-65.
36. Rotello RJ, Fernandez PA, Yuan J (1994): Anti-apogens and anti-engulfens: Monoclonal antibodies reveal specific antigens on apoptotic and engulment cells during chicken embryonic development. Development 120:1421-1431.
37. Saiki I, Fujii H, Yoneda J, Abe F, Nakajima M, Tsunio T, Azuma I (1993): Role of aminopeptidase-N (CD13) in tumor-cell Invasion and extracellular matrix degradation. Int J Cancer 54:137-143.
38. Savill J, Fadok V, Henson P, Haslett C (1993): Phagocyte recognition of cells undergoing apoptosis. Immunol Today 14:131-136.
39. Suda H, Aoyagi T, Takeuchi T, Umezawa H (1976): Inhibition of aminopeptidase-B and leucine aminopeptidase by bestatin and its stereoisomer. Arch Biochem Biophys 177: 196-200.
40. Sun X-M, Snowden RT, Skilleter DN, Dinsdale D, Ormerod MG, Cohen GM (1993): A flow-cytometric method for the separation and quantitation of normal and apoptotic thymocytes. Anal Biochem 204:351-356.
41. Tomei LD, Shapiro JP, Cope FO (1993): Apoptosis in C3H/ 10T1/2 mouse embryonic cells: Evidence of internucleosomal DNA modification in the absence of double-strand cleavage. Proc Natl Acad Sci USA 90:853-857.
42. Walker NI, Harmon BV, Gobe GC, Kerr JFR (1988): Patterns of cell death. Methods Ach Exp Pathol 13:18-54.
43. Walker PR, Kokileva L, LeBlanc J, Sikorska M (1994): Detection of the initial stages of DNA fragmentation in apoptosis. Biotechniques 15:1032-1040.
44. Wyllie AH (1993): Apoptosis (The 1992 Frank Rose Memorial Lecture). Br J Cancer 67:205-208.