Ineffectiveness of intravenous β2-agonists on improving exercise tolerance in patients with reversible chronic airway obstruction

Respiration

Volumn 63, Issue 1, 1996, Pages 8-16

  Malerba, M ^a   Boni, E ^a   Tantucci, C ^b   Filippi, B ^a   Romagnoni, G ^c   Grassi, V ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c Zambon Group SpA   (Italy)

Author keywords

Airflow limitation; Broxaterol; Exercise; Salbutamol; 2 Agonists

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BROXATEROL; SALBUTAMOL;

ADULT; AGED; ANAEROBIC THRESHOLD; ARTERIAL GAS; ARTERIAL OXYGEN TENSION; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EXERCISE TOLERANCE; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADRENERGIC BETA-AGONISTS; AGED; AIRWAY OBSTRUCTION; ALBUTEROL; BLOOD GAS ANALYSIS; CHRONIC DISEASE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXERCISE TOLERANCE; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; ISOXAZOLES; MALE; MIDDLE AGED; SPIROMETRY;

EID: 0030050862     PISSN: 00257931     EISSN: 14230356     Source Type: Journal    
DOI: 10.1159/000196509     Document Type: Article

References (40)

1. American Thoracic Society: Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease and asthma. Am Rev Respir Dis 1987;136:225-234.
2. Anthonisen NR. Wriglu EC and IPPB Trial Group: Bronchodilator response in chronic obstructive pulmonary disease. Am Rev Respir Dis 1986:133:814-819.
3. Brown HV. Wasscrmann K: Exercise performance in chronic obsturctive pulmonary disease. Med Clin North Am 1981:65:525-546.
4. Stubbing DG. Pengelly LD. Morse JLC. et al: Pulmonary mechanics during exercise in subjects w'ith chronic airflow obstruction. J Appl Physiol 1980:49:511-515.
5. Grimby G, Flgefors B. Oxhoj H: Ventilatory levels and chest wall mechanics during exercise in obstructive lung disease. Scand J Respir Dis 1973:54:45-52.
6. Minh VD, Lee HM, Dolan GF, et al: Hypoxemia during exercise in patients with chronic-obstructive pulmonary disease. Am Rev Respir Dis 1979;120:787-794.
7. Dantzker DR. D’Alonzo GE: The effect of exercise on pulmonary gas exchange in patients with severe chronic obstructive pulmonary dis ease. Am Rev Respir Dis 1986:134:1135-1139.
8. Roussos C. Macklem PT: The respiratory muscles. N Engl J Med 1982;307:786-797.
9. Bye PTP. Farkas GA. Roussos C: Respiratory factors limiting exercise. Annu Rev Physiol 1983:45:439-451.
10. Khaja F, Parker JO: Right and left ventricular performance in chronic obstructive lung disease. Am Heart J 1971:82:319-327.
11. Malthay RA, Berger HJ, Davies R, et al: Right and left ventricular exercise performance in chronic obstructive pulmonary disease: Radionuclide assessment. Ann Intern Med 1980:93: 234-239.
12. Vathenen AS, Britton JR, Ebden P, et al: High dose inhaled albuterol in severe chronic airflow limitation. Am Rev Respir Dis 1988:138:850-855.
13. Teule GJJ. Majid PA: Hemodynamic effects of terbutaline in chronic obstructive airways disease. Thorax 1980;35:536-542.
14. Brent BN. Mahler DA. Berger HJ. et al: Augmentation of right ventricular performance in chronic obstructive pulmonary disease by terbutaline. A combined radionuclide and hemodynamic study. Am J Cardiol 1982:50:313-319.
15. Nava S. Crotti P, Gurrieri G, Fracchia C, Ram-pulla C: Effect of a beta-2-agonist (broxaterol) on respiratory-muscle strength and endurance in patients with irreversible airway obstruction. Chest 1992:101:133-140.
16. Wagner PD. Dantzker DR, Dueck R. Clausen JL. West JB: Ventilation perfusion inequality in chronic obstructive pulmonary disease. J Clin Invest 1977:59:203-209.
17. Gundogdu AS, Brown PM. Juul S. Sachs L. Sonksen PH: Comparison of hormonal and metabolic effect of salbutamol infusion in normal subjects and insulin-requiring diabetics. Lancet 1979;vol ii: 1317-1321.
18. Perruchoud AP. Brundler H, Godly R, Imhof E, Herzog H: Broxaterol (Z. 1170), a new oral beta-2-adrenoceptor agonist compared with salbutamol. Respiration 1987;51:113-118.
19. Petty TL: Definitions in chronic obstructive pulmonary disease. Clin Chest Med 1990;2: 363-373.
20. European Community for Coal and Steel: Standardization of lung function tests. Bull Eur Physiopathol Respir 1983; 19:(S5) 1-95.
21. Beaver WL, Wassermann K. Whipp BJ: A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 1986:60:2020-2027.
22. Sunderrajan EV, Byron WA. McKenzie WN, et al: The effect of terbutaline on cardiac function in patients with stable chronic obstruction lung disease. JAMA 1983:250:2051-2056.
23. Stockely RA. Finnegan P. Bishop JM: Effect of intravenous terbutaline on arterial blood gas tensions, ventilation and pulmonary circulation in patients with chronic bronchitis and cor pulmonale. Thorax 1977;32:601-605.
24. Tantucci C. Bruni B. Dottorini ML. et al: Acute ventilatory and gas exchange effects of a new beta-2-agonist, broxaterol, in asthmatics. Int J Clin Pharmacol Res 1990:10:183-189.
25. Killian KJ, Leblanc P. Martin DH, et al: Exercise capacity and ventilatory, circulatory and symptom limitation in patients with chronic airflow limitation. Am Rev Respir Dis 1992: 146:935-940.
26. Leblanc P. Bowie DM. Summers E, Jones NL, Killian KJ: Breathlessness and exercise in patients with cardiorespiratory disease. Am Rev Respir Dis 1986:133:21-25.
27. Bye PTP. Esau SA. Levy RD. Shiner RJ. et al: Ventilatory muscle function during exercise in air and oxygen in patients with chronic airflow limitation. Am Rev RespirDis 1985; 132:236-240.
28. Grassino A. Gross D. Macklem PT, Roussos C, Tagelbaum G: Inspiratory muscle fatigue as a factor limiting exercise. Bull Eur Physiopathol Respir 1979;15:105-111.
29. Pardy RL, Rivington RN, Despas PJ, Macklem PT: The effects of inspiratory muscle training on exercise performance in chronic air = flow limitation. Am Rev Respir Dis 1981; 123:426-433.
30. Fitting JW: Respiratory muscle fatigue limiting physical exercise? Eur Respir J 1991:4:103-108.
31. Corea L. Bentivoglio M, Verdecchia P. et al: Noninvasive assessment of chronotropic and inotropic response to preferential beta-1-and beta-2-adrenoceptor stimulation. Clin Pharma-colTher 1984:35:776-781.
32. Vincent HH, Manin’t Veld AJ, Boosma F. Wenting GJ. Schalekamp MADH: Elevated plasma noradrenaline in response to beta-adre-noceptor stimulation in man. Br J Clin Pharmacol 1982;13:717-721.
33. Chiolero R. Flatt JP. Revelly JP. Jequier E: Effects of catecholamines on oxygen consumption and oxygen delivery in critically ill patients Chest 1991:100:1676-1784.
34. Stewart RI. Lewis CM: Arterial oxygenation and oxygen transport during exercise in patients with chronic obstructive pulmonary disease. Respiration 1986;49:161-169.
35. Barbera JA, Roca J, Ramirez L, Wagner PD, Usseti P. Rodriguez-Roisin R: Gas exchange during exercise in mild chronic obstructive pulmonary disease. Am Rev Respir Dis 1991:144: 520-525.
36. Agusti AGN. Barbera JA. Roca J. Wagner PD. Guitart R. Rodriguez-Roisin R: Hypoxic pulmonary vasoconstriction and gas exchange during exercise in chronic obstructive pulmonary disease. Chest 1990:97:268-275.
37. Tobin MJ. Hughes JA, Hutchinson DCS: Effects of ipratropium bromide and fenoterol aerosols on exercise tolerance. Eur J Respir Dis 1984;65:441-446.
38. Leitch AG, Hopkin JM, Ellis DA. Merchant S. McHardy GJR: The effect of aerosol ipratropium bromide and salbutamol on exercise tolerance in chronic bronchitis. Thorax 1978:33: 711-713.
39. Papiris S. Galavotti V, Sturani C: Effects of beta-agonists on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease. Respiration 1986:49:101-108.
40. Guyalt G. Townsend M. Pugsley SO. et al: Bronchodilators in chronic air-flow limitation. Am Rev RespirDis 1987;135:1069-1074.