Analysis of phosphorylation sites of herpes simplex virus type 1 ICP4

Journal of Virology

Volumn 70, Issue 2, 1996, Pages 1061-1071

  Xia, Kai ^a   Deluca, Neal A ^b   Knipe, David M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; PHOSPHOAMINO ACID; PHOSPHOPEPTIDE; PROTEIN KINASE C; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HERPES SIMPLEX VIRUS 1; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VERO CELL; VIRAL GENETICS; VIRUS INFECTION;

EID: 0030050772     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.2.1061-1071.1996     Document Type: Article

References (63)

1. Ackermann, M., D. K. Braun, L. Pereira, and B. Roizman. 1984. Characterization of herpes simplex virus 1 α proteins 0. 4. and 27 with monoclonal antibodies. J. Virol. 52:108-118.
2. Blaho, J. A., and B. Roizman. 1991. ICP4. the major regulatory protein of herpes simplex virus, shares features common to GTP-binding proteins and is adenylated and guanylated. J. Virol. 65:3759-3769.
3. Boyle, W. J., P. Van Der Geer, and T. Hunter. 1991. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates Methods Enzymol. 201:110-148.
4. Chapman, C. J., J. D. Harris, M. A. Hardwicke, R. M. Sandri-Goldin, M. K. L. Collins, and D. S. Latchman. 1992 Promoter independent activation of heterologous gene expression by the herpes simplex virus immediate-early protein ICP27. Virology 186:573-578
5. Collett, M. S., and R. L. Erikson. 1978. Protein kinase activity associated with the avian sarcoma virus src gene product. Proc. Natl. Acad. Sci. USA 75:2021-2024
6. DeLuca, N. A., A. McCarthy, and P. A. Schaffer. 1985. Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4. J Virol. 56:558-570.
7. DeLuca, N. A., and P. A. Schaffer. 1988. Physical and functional domains of the herpes simplex virus transcnptional regulatory protein ICP4. J Virol. 62:732-743.
8. Dixon, R. A. F., and P. A. Schaffer. 1980. Fine-structure mapping and functional analysis of temperature-sensitive mutants in the gene encoding the herpes simplex virus type 1 immediate early protein VP175. J Virol. 36:189-203.
9. Everett, R. D. 1984. Transactivation of transcription by herpes virus products: requirement for Two HSV-1 immediate-early polypeptides for maximum activity. EMBO J. 3:3135-3141
10. Faber, S. W., and K. W. Wilcox. 1986. Characterization of a herpes simplex virus regulatory protein: aggregation and phosphorylation of a temperature sensitive variant of ICP4. Arch. Virol. 91:297-312
11. Gelman, I. H., and S. Silverstein. 1985 Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene Proc. Natl. Acad Sci. USA 82:5265-5269
12. Godowski, P. J., and D. M. Knipe. 1986 Transcriptional control of herpes-virus gene expression: gene functions required for positive and negative regulation. Proc. Natl. Acad Sci. USA 83:256-260.
13. Gu, B., and N. DeLuca. 1994. Requirements for activation of transcription by the herpes simplex virus regulatory protein ICP4 in vitro J. Virol. 68:7953-7965.
14. Gu, B., R. Kuddus, and N. DeLuca. 1995. Inhibition of activator-mediated transcription by herpes simplex virus ICP4 by a mechanism involving interactions with the basal transcription factors TATA-binding protein and TFIIB. Mol. Cell Biol. 15:3618-3626.
15. Hanks, S. K., and A. M. Quinn. 1991 Protein kinase catalytic domain sequence database, identification of conserved features of primary structure and classification of family members. Methods Enzymol. 200:38-62
16. Hardy, W. R., and R. M. Sandri-Goldin. 1994. Herpes simplex virus inhibits host cell splicing and resulatory protein ICP27 is required for this effect. J. Virol 68:7790-7799.
17. Hunter, T., and J. A. Cooper. 1985 Protein tyrosine kinases. Annu. Rev. Biochem 54:897-930.
18. Imbalzano, A. N., A. A. Shepard, and N. A. DeLuca. 1990. Functional relevance of specific interactions between herpes simplex virus type 1 ICP4 and sequences from the promoter-regulatory domain of the viral thymidine kinase gene. J. Virol. 64:2620-2631
19. Jean, S., K. M. LeVan, and D. M. Knipe. Unpublished data.
20. Kattar-Cooley, P., and K. W. Wilcox, 1989. Characterization of the DNA-binding properties of herpes simplex virus regulatory protein ICP4 J. Virol. 63:696-704.
21. Knipe, D. M., W. T. Ruyechan, B. Roizman, and I. A. Halliburton. 1978. Molecular genetics of herpes simplex virus: demonstration of regions of obligatory and nonobligatory identity within diploid regions of the genome by sequence replacement and insertion. Proc. Natl. Acad. Sci. USA 75:3896-3900.
22. Knipe, D. M., and A. E. Spang. 1982. Definition of a series of stages in the association of two herpesviral proteins with the cell nucleus. J. Virol 43: 314-324.
23. Kramer, M. F., and D. M. Coen. 1995. Quantification of transcripts from the ICP4 and thymidme kinase genes in mouse ganglia latently infected with herpes simplex virus. J. Virol. 69:1389-1399.
24. Kristie, T. M., and B. Roizman. 1986. α4. the major regulatory protein of herpes simplex virus type 1. is stable and specifically associated with the promoter-regulatory domains of a genes and of selected other viral genes. Proc. Natl. Acad. Sci. USA 83:3218-3222.
25. Leader, D. P., and M. Katan. 1988. Viral aspects of protein phosphorylation. J. Gen. Virol 69:1441-1464.
26. McCarthy, A. M., L. McMahan, and P. A. Schaffer. 1989. Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient. J. Virol. 63:18-27.
27. McLaughlin, J., A. Phelan, C. Loney, R. M. Sandri-Goldin, and J. B. Clements. 1992. Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3 processing. J. Virol. 66:6939-6945.
28. McMahan, L., and P. A. Schaffer. 1990 The repressing and enhancing functions of the herpes simplex virus regulatory protein ICP27 map to C-terminal regions and are required to modulate viral gene expression very early in infection. J. Virol. 64:3471-3485.
29. Michael, N., D. Spector, P. Mavromara-Nazos, T. M. Kristie, and B. Roizman. 1988. The DNA-bindmg properties of the major regulatory protein α4 of herpes simplex virus. Science 239:1531-1534.
30. Mullen, M., D. M. Ciufo, and G. S. Hayward. 1994. Mapping of intracellular localization domains and evidence for colocalization interactions between the IE110 and IE175 nuclear transactivator proteins of herpes simplex virus, J. Virol. 68:3250-3266.
31. Muller, M. T. 1987. Binding of the herpes simplex virus type 1 gene product ICP4 to its own transcription start site. J. Virol. 61:858-865.
32. O'Hare, P., and G. S. Hayward. 1985. Evidence for a direct role for both the 175.000- and 110.000-molecular-weight immediate-early proteins of herpes simplex virus in the trans-activation of delayed-early promoters J Virol. 53:751-760.
33. O'Hare, P., and G. S. Hayward. 1985. Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation. J Virol 56: 723-733.
34. Papavassiliou, A. G., K. W. Wilcox, and S. J. Silverstein. 1991 The interaction of ICP4 with cell/infected-cell factors and its state of phosphorylation modulate differential recognition of leader sequences in herpes simplex virus DNA. EMBO J. 10:397-460.
35. Paterson, T., and R. D. Everett. 1988. Mutational dissection of the HSV-1 immediate-early protein Vmw175 involved in transcriptional transactivation and repression. Virology 166:186-196.
36. Paterson, T., and R. D. Everett. 1990 A prominent serine-rich region in Vmw175, the major transcriptional regulator protein of herpes simplex virus type 1, is not essential for virus growth in tissue culture J Gen. Virol. 71:1775-1783.
37. Pereira, L., M. H. Wolff, M. Fenwick, and B. Roizman. 1977 Regulation of herpes virus macromolecular synthesis. V. Properties of a polypeptide made in HSV-1 and HSV-2 infected cells Virology 77:733-749.
38. Preston, C. M. 1979. Abnormal properties of an immediate early polypeptide in cells infected with the herpes simplex virus type 1 mutant tsK. J Virol. 32:357-369.
39. Preston, C. M., and E. L. Notarianni. 1983. Poly(ADP-ribosyl)ation of a herpes simplex virus immediate early polypeptide. Virology 131:492-501
40. Quinlan, M. P., and D. M. Knipe. 1985. Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions. Mol. Cell. Biol. 5:957-963.
41. Rice, S. A., and D. M. Knipe. 1988. Gene specific transactivation by herpes simplex virus type 1 α protein ICP27. J. Virol. 62:3814-3823.
42. Rice, S. A., L. Su, and D. M. Knipe. 1989. Herpes simplex virus α protein ICP27 possesses separable positive and negative reaulatory activities J Virol 63:3399-3407
43. Ridley, R. G., H. V. Patel, G. E. Gerber, R. C. Morton, and K. B. Freeman. 1986 Complete nucleotide and derived amino acid sequence of cDNA encoding the mitochondrial uncoupling protein of rat brown adipose tissue lack of a mitochondrial targeting presequence. Nucleic Acids Res 14:4025-4035.
44. Roberts, M. S., A. Boundy, P. O'Hare, M. C. Pizzorno, D. M. Ciufo, and G. S. Hayward. 1988. Direct correlation between a negative autoregulatory response element at the cap site of herpes simplex virus type 1 IE175 (α4) promoter and a specific binding site for the IE175 (ICP4) protein. J. Virol. 62:4307-4320.
45. Sacks, W. R., C. C. Greene, D. P. Aschman, and P. A. Schaffer. 1985. Herpes simplex virus type 1 ICP27 is an essential regulatory protein. J. Virol. 55: 796-805.
46. Samaniego, L. A., A. L. Webb, and N. A. DeLuca. 1995. Functional interactions between herpes simplex virus immediate-early proteins during infection: gene expression as a consequence of ICP27 and different domains of ICP4. J. Virol. 69:5705-5715.
47. Sandri-Goldin, R. M., and G. E. Mendoza. 1992. A herpes virus regulatory protein appears to act posttranscriptionally by affecting mRNA processing. Genes Dev. 6:848-863.
48. Schlessinger, J. 1986. Allosteric regulation of the epidermal growth factor receptor kinase. J. Cell Biol. 103:2067-2072.
49. Shepard, A. A., A. N. Imbalzano, and N. A. DeLuca. 1989. Separation of primary structural components conferring autoregulation, transactivation, and DNA-binding properties to the herpes simplex virus transcriptional regulatory protein ICP4. J. Virol. 63:3714-3728.
50. Shepard, A. A., P. Tolentino, and N. A. DeLuca. 1990. trans-dominant inhibition of herpes simplex virus transcriptional regulatory protein ICP4 by heterodimer formation. J. Virol. 64:3916-3926.
51. Showalter, S. D., M. Zweig, and B. Hampar. 1981 Monoclonal antibodies to herpes simplex virus type 1 proteins, including the immediate-early protein ICP4. Infect. Immun. 34:684-692.
52. Smith, C. A., P. Bates, R. Rivera-Gonzalez, B. Go, and N. A. DeLuca. 1993. ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB. J. Virol. 67:4676-4687.
53. Su, L., and D. M. Knipe. 1989. Herpes simplex virus a protein ICP27 can inhibit or augment viral gene transactivation. Virology 170:496-504.
54. Tseng, C., and N. A. DeLuca. Unpublished results.
55. Watson, R., and J. B. Clements. 1978. Characterization of transcription deficient, temperature sensitive mutants of herpes simplex virus type 1. Virology 91:364-379.
56. Watson, R., and J. B. Clements. 1980. A herpes simplex virus type 1 function continuously required for early and late virus RNA synthesis. Nature (London) 285:329-330.
57. Wettenhall, R. E. H., and F. J. Morgan. 1984. Phosphorylation of hepatic ribosomal protein S6 on 80 and 40S ribosomes: primary structure of S6 in the region of the major phosphorytation sites for cAMP-dependent protein kinases. J. Biol. Chem. 259:2084-2091.
58. Wilcox, K. W., A. Kohn, E. Sklyanskaya, and B. Roizman. 1980. Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA. J. Virol. 33:167-182
59. Wu, C.-L., and K. W. Wilcox. 1990. Codons 262 to 490 from the herpes simplex virus ICP4 gene are sufficient to encode a sequence-specific DNA binding protein. Nucleic Acids Res. 18:531-538.
60. Wu, C.-L., and K. W. Wilcox. 1991. The conserved DNA-binding domains encoded by the herpes simplex virus type 1 ICP4. pseudorabies virus IE180, and varicella-zoster virus ORF62 genes recognize similar sites in the corresponding promoters. J. Virol 65:1149-1159.
61. Xia, K., N. A. DeLuca, and D. M. Knipe. Unpublished results.
62. Xia, K., D. M. Knipe, and N. A. DeLuca. 1996. Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication J. Virol. 70:1050-1060.
63. Yarden, Y., and A. Ullrich. 1988 Growth factor receptor tyrosine kinases Annu. Rev. Biochem. 57:443-478.