Sequential methotrexate and 5-fluorouracil as second-line chemotherapy for advanced colorectal cancer patients pretreated with 5-fluorouracil and leucovorin: A GISCAD study

Journal of Chemotherapy

Volumn 8, Issue 1, 1996, Pages 82-84

  Zaniboni, A ^a  

^a SPEDALI CIVILI   (Italy)

Author keywords

Colorectal cancer; Fluorouracil; Leucovorin; Methotrexate

Indexed keywords

FLUOROURACIL; FOLIC ACID; METHOTREXATE;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; COLORECTAL CANCER; DIARRHEA; DRUG EFFICACY; DRUG TOLERANCE; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LEUKOPENIA; MALE; MUCOSA INFLAMMATION; NAUSEA; ORAL DRUG ADMINISTRATION; VOMITING;

EID: 0030050399     PISSN: 1120009X     EISSN: None     Source Type: Journal    
DOI: 10.1179/joc.1996.8.1.82     Document Type: Article

References (6)

1. Advanced Colorectal Cancer Meta-Analysis Project. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. J Clin Oncol 1992; 10: 896-903.
2. Advanced Colorectal Cancer Meta-Analysis Project. Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer. J Clin Oncol 1994; 12:960-969.
3. Sotos GA, Grogan L, Allegra TC. Preclinical and clinical aspects of biomodulation of 5-fluorouracil. Cancer Treat Rev 1994;20: 11-49.
4. Marsh JC, Bertino JR, Katz KH et al. The influence of drug interval on the effect of methotrexate and fluorouracil in the treatment of advanced colorectal cancer. J Clin Oncol 1991;9: 371-380.
5. Izzo J, Cvitkovic E, Zarba J et al. Low dose 5-FU continuous infusion in advanced colorectal cancer: clinical evidence for reversal of acquired/intrinsic resistance to 5-FU or 5-FU + folinic. Ann Oncol 1992;3 (Suppl 5): 20(Abstr 76).
6. Sobrero A, Aschele C, Guglielmi A et al. High activity and low toxicity of alternating bolus and continuous infusion 5-fluorouracil with schedule-oriented biochemical modulation in advanced colon cancer patients. Proc ASCO 1994; 13: (Abstr 588).