Pilot-scale verification of a computer-based simulation for the centrifugal recovery of biological particles

Bioprocess Engineering

Volumn 14, Issue 2, 1996, Pages 81-89

  Clarkson, A I ^a,b   Bulmer, M ^a   Titchener Hooker, N J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Costain House ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ORGANIC COMPOUND;

ARTICLE; BIOMASS; CENTRIFUGATION; COMPUTER SIMULATION; CONTROLLED STUDY; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL;

EID: 0030049916     PISSN: 0178515X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00387961     Document Type: Article

References (37)

1. Ambler, C.M.: The evaluation of centrifuge performance. Chem. Eng. Prog., March, (1952) 150-158
2. Bartsch, M.J.: Mathematische Formeln, VEB Fachbuchverlag, Leipzig, (1977)
3. Baron, G.; Wajc, S.: Fluidised settling in centrifuges, Synopsis 686, Chemical Engineering Technology, 4, (1979) 333-338
4. Bell, D.J.; Dunnill, P.: Shear disruption of soya protein precipitate particles and the effect of ageing in a stirred tank, Biotechnology and Bioengineering, 24, (1982) 1271-1285
5. Bell, D.J.; Dunnill, P.: The influence of precipitation reactor configuration on the centrifugal recovery of isoelectric soya protein precipitate, Biotechnology and Bioengineering, 24, (1982b) 2319-2336
6. Bell, D.J.; Hoare, M.; Dunnill, P.: The formation of protein precipitates and their centrifugal recovery, Advances in Biochemical Engineering/Biotechnology, 26, (1983) Ed. A. Fiechter. Berlin: Springer Verlag, Berlin, 1-72
7. Bell, D.J.; Heywood-Waddington, D.; Hoare, M.; Dunnill, P.: The density of protein precipitates and its effect on centrifugal sedimentation. Biotechnology and Bioengineering, 24, (1982) 127-141
8. Bell, D.J.; Brunner, K.-H.: A method for the evaluation of floc breakup in centrifuges, Filtration and Separation, 20 (4), (1983) 274-301
9. Bergmeyer, H.O.: Methods of Enzymic Analysis, Verlag Chemie, Weinheim (1979)
10. Bohman, H.: Hydrodynamics of the liquid in the disc-stack of a centrifugal separator, Paper F3, 1st European Conference on Mixing and Centrifugal Separation, September, Cranfield (1974)
11. Bradford, M.: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, 72, (1976) 248-254
12. Brunner, K.-H.; Molerus, O.: Theoretical and experimental investigation of separation efficiency of disc centrifuges, German Chemical Engineering, 2, (1979) 228-233
13. Brunning, P.: Scale-up Probleme bei Tellerseparatoren, Technische Dokumentation, Westfalia Separator AG, Oelde, Germany (1987)
14. Bulmer, M.; Clarkson, A.I.; Titchener-Hooker, N.J.: Pilot-scale verification of bioprocess models, paper in preparation, (1955)
15. Clarkson, A.I.; Lefevre, P.; Titchener-Hooker, N.J.: A study of process interactions between cell disruption and debris clarification stages in the recovery of yeast intracellular proteins, Biotechnol. Prog., 3, (1993) 462-467
16. Clarkson, A.I.; Bulmer, M.; Siddiqi, S.; Titchener-Hooker, N.J.: Pilot-scale verification of bioprocess models, Computers Chem. Eng., 18, (1994) S651-S655
17. Clarkson, A.I.; Bulmer, M.; Titchener-Hooker, N.J.: Pilot-scale verification and a computer-based simulation for fractional protein precipitation, Paper accepted Bioproc. Eng. (1995)
18. Datar, R.; Rosen, C.J.: Centrifugal separation in the recovery of intracellular protein from E. coli, The Chemical Engineering Journal, 34, (1987) B49-B56
19. Dehghani, M.; Bulmer, M.; Thornhill, N.F.; Gregory, M.E.; Ison, A.: Assays for fermentation processes with measurement variability analysis, Paper accepted Bioproc. Eng (1995)
20. Gupta, S.K.: Scale-up procedures for disc-stack centrifuges, Chemical Engineering Journal, 22, (1981) 43-49
21. Hetherington, P.J.; Follows, M.; Dunnill, P.; Lilly, M.D.: Release of protein from Baker's yeast (Saccharomyces cerevisiae) by disruption in an industrial homogeniser, Trans. Instn. Chem. Engrs., 49, (1971) 142-148
22. Hemfort, H.: Separatoren, Technische Dokumentation der Westfalia Separator AG, Oelde, Germany (1979)
23. Hemmingson, A.: Applied Biochemistry and Bioengineering, 2, (1979) 157-183
24. Higgins, J.J.; Lewis, D.J.; Daly, W.H.; Mosqueira, F.G.; Dunnill, P.; Lilly, M.D.: Investigation f the unit operations involved in the continuous flow isolation of β-galactosidase, Biotechnology and Bioengineering, 20, (1978) 159-182
25. Mannweiler, K.: The recovery of biological particles in high-speed continuous centrifuges with special reference to feed-zone bream-up effects, Ph.D. Thesis, University of London (1990)
26. Mannweiler, K.; Hoare, M.: The scale-down of an industrial disc stack centrifuge, Bioprocess Engineering, 8, (1992) 19-25
27. Mannweiler, K.; Titchener-Hooker, N.J.; Hoare, M.: Biochemical Engineering improvements in the centrifugal recovery of biological particles, I. Chem. E. Symposium Advances in Biochemical Engineering, (1989) 105-117
28. Mosqueira, F.G.; Higgins, J.J.; Dunnill, P.; Lilly, M.D.: Characteristics of mechanically disrupted Baker's yeast in relation to its separation in industrial centrifuges, Biotechnology and Bioengineering, 23, (1981) 335-343
29. Pantelides, C.C.: Speed-up recent advances in process simulation, Computers and Chemical Engineering, 12 (7), (1988) 745-755
30. Rehm, H.: Industrielle Mikrobiologie, Berlin, Heidelberg, New York, Tokyo, Springer-Verlag (1980)
31. Richardson, J.F.; Zaki, W.N.: Sedimentation and Fluidisation: Part I, Trans. Instn. Chem. Engrs. 32, (1954) 35-53
32. Rumpus, J.: Ph.D. Thesis, University of London (1995)
33. Sargent, R.W.H.; Westerberg, A.W.: SPEED-UP in chemical engineering design, Trans. Instn. Chem. Engrs., 42, (1964) T190-T197
34. Siddiqi, S.F.; Titchener-Hooker, N.J.; Ayazi Shamlou, P.: The operating conditions on the generation of cell debris in high-pressure homogenisation of Baker's yeast, Biotech. Bioeng., (submitted) (1995)
35. Stokes, G.G.: On the effect of the internal fraction on the motion pendulum, Trans. Cam. Phil. Soc. 9, (1951) 8
36. Titchener-Hooker, N.J.; Hoare, M.; Dunnill, P.: New approaches to the more efficient purification of proteins and enzymes, Biochemical Engineering, 6, Annals New York Acad. Sci., 589 (1991) 157-171
37. Willus, C.A.; Fitch, B.: Centrifuges: flow patterns in a disc centrifuge, Chemical Engineering Progress, 69 (9), (1973) 93-94