Glycoproteins of the carcinoembryonic antigen (CEA) family are expressed in sweat and sebaceous glands of human fetal and adult skin

Journal of Investigative Dermatology

Volumn 106, Issue 1, 1996, Pages 64-69

  Metze, Dieter ^a   Bhardwaj, Ranjit ^a   Amann, Udo ^a   Eades Perner, Anne Marie ^b   Neumaier, Michael ^c   Wagener, Christoph ^c   Jantscheff, Peter ^b   Grunert, Fritz ^b   Luger, Thomas A ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

CEA; Sebaceous glands; Sweat glands; Transgenic mice

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; GLYCOPROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CONTROLLED STUDY; FEMALE; FETUS; FETUS DEVELOPMENT; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SEBACEOUS GLAND; SWEAT GLAND; TRANSGENIC MOUSE;

EID: 0030049853     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12327258     Document Type: Article

References (48)

1. Thompson J, Zimmermann W: The carcinoembryonic antigen gene family: structure, expression and evolution. Tumor Biol 9:63-83, 1988
2. Thomas P, Toth CA, Saini KS, Jessup M, Steele G: The structure, metabolism and function of the carcinoembryonic antigen gene family. Biochem Biophys Acta 1032:177-189, 1990
3. Thompson JA, Grunert F, Zimmermann W: Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal 5:344-366, 1991
4. Beauchemin N, Turbide C, Afar O, Bell J, Raymond M, Stanners CP, Fuks A: A mouse analogue of the human carcinoembryonic antigen. Cancer Res 49:2017-2021, 1989
5. Katz AM, Rosenthal D, Sauder DN: Cell adhesion molecules. Structure, function, and implication in a variety of cutaneous and other pathologic conditions. Int J Dermatol 30:153-160, 1991
6. Zhou H, Fuks A, Stanners CP: Specificity of intercellular adhesion mediated by various members of the immunoglobulin supergene family. Cell Growth Differ 1:209-215, 1990
7. 2+-dependent intercellular adhesion molecule. Cell Growth Differ 1:527-533, 1990
8. Turbide C, Rojas M, Stanners CP, Beauchemin N: A mouse carcinoembryonic antigen gene family member is a calcium-dependent cell adhesion molecule. J Biol Chem 266:309-315, 1991
9. Oikawa S, Inuzuka C, Kuroki M, Matsuoka Y, Kosaki G, Nakazato H: Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion. Biochem Biophys Res Commun 164:39-45, 1989
10. Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP: Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 57:327-334, 1989
11. Kuijpers TW, Hoogerwerf M, van der Laan LJW, Nagel G, van der School CE, Grunert F, Roos D: CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells. J Cell Biol 118:457-466, 1992
12. Sauter SL, Rutherfurd SM, Wagener C, Shively JE, Hefta SA: Identification of the specific oligosaccharide sites recognized by type 1 fimbriae from Escherichia colo on non-specific cross-reacting antigen, a CD66 cluster granulocyte glycoprotein. J Biol Chem 268:15510-15516, 1993
13. Leusch HG, Drzeniek Z, Markos-Pusztal Z, Wagener C: Binding of Escherichia coli and samonella strains to members of the carcinoembryonic antigen family: Differential binding inhibition by aromatic α-glycoside of mannose. Infect Immun 59:2051-2057, 1991
14. Sauter SL, Rutherfurd SM, Wagener C, Shively JE, Hefta SA: Binding of nonspecific cross-reacting antigen, a granulocyte membrane glycoprotein, to Escherichia coli expressing type 1 fimbriae. Infect Immun 59:2485-2493, 1991
15. Hinoda Y, Neumaier M, Hefta SA, Drzeniek Z, Wagener C, Shively L, Hefta LJF, Shively JE, Paxton RJ: Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen. Proc Natl Acad Sci USA 85:6959-6963, 1988
16. Penneys NS, Kott-Blumenkranz R, Buck BE: Carcinoembryonic antigen in fetal eccrine glands: an immunohistochemical study. Pediatr Dermatol 1:281-282, 1984
17. Eto H, Nishiyama S: Sweat glands cells. In: Hiroaki U, Hideo Y (eds.). A Colour Atlas of Dermato-Immunohistocytology. Wolfe Medical Publications, London 1989, pp 40-41
18. Penneys NS, Nadji M, Churchill McKinney E: Carcinoembryonic antigen present in human eccrine sweat. J Am Acad Dermatol 4:401-403, 1981
19. Cotton DWK: Immunohistochemical staining of normal sweat glands. Br J Dermatol 114:441-449, 1986
20. Eades-Perner AM, van der Putten H, Hirth A, Thompson J, Neumaier M, von Kleist S, Zimmermann W: Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern. Cancer Res 54:4196-4176, 1994
21. Hammarstrom S, Shively JE, Paxton RJ, Beatty BG, Larsson A, Ghosh R, Bonner O, Buchegger F, Mach JP, Burtin P, Seguin P, Darbouret B, Degorce F, Sertour J, Jolu JP, Fuks A, Kalthoff H, Schmiegel W, Arndt R, Kloppel G, von Kleist S, Grunert F, Schwatz K, Matsuoka Y, Kuroki M, Wagener C, Weber T, Yachi A, Imai K, Hishikawa N, Tsujisaki M: Antigenic sites in carcinoembryonic antigen. Cancer Res 49:4852-4858, 1989
22. Grunert F, Soubt M, Jantscheff P, Nagel G: Specificity and epitope localization of CD 66/67 monoclonal antibodies. In: Schlossmann SF, Boumsell L, Gilks W, Harlan J, Hishimoto T, Morimoto C, Ritz J, Shaw S, Springer TA, Fedder TF, Todd RF (eds). Leukocyte Typing V, White Cell Differentiation Antigens. Oxford Press, Oxford, UK, 1995 (in press)
23. Grunert F, AbuHarfeil N, Schwarz K, von Kleist S. Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns. Int J Cancer 36:357-362, 1985
24. Daniel S, Nagel G, Johnson JB, Lobo FM, Jantscheff P, Kuroki M, von Kleist S, Grunert F: Determination of the specificities of monoclonal antibodies recognizing members of the CEA family using a panel of transfectants. Int J Cancer 55:303-310, 1993
25. Neumaier M, Shively L, Chen FS, Gaida FJ, Ilgen S, Paxton RJ, Shively JE, Riggs AD: Cloning of the genes for T84.66, an antibody that has a high specificity and affinity for carcinoembryonic antigen, and expression of chinieric human/mouse T84.66 genes in myeloma and Chinese hamster ovary cells. Cancer Res 50:2128-2134, 1990
26. Drzeniek Z, Lamerz R, Fenger U, Wagener C, Haubeck HD: Identification of membrane antigens in granulocytes and colonic carcinoma cells by a monoclonal antibody specific for biliary glycoprotein, a member of the carcinoembryonic antigen family. Cancer Lett 56:173-176, 1991
27. Nap M, ten Hoor KA, Fleuren GJ: Cross-reactivity with normal antigens in commercial anti-CEA sera, used for immunohistology. The need for tissue controls and absorption. Am J Clin Pathol 79:25-31, 1983
28. Griffiths AD, Malmqvist M, Marks JD, Bye JM, Embleton MJ, McCafferty J, Baier M, Hollinger KP, Gorick BD, Hughes-Jones NC, Hoogenboom HR, Winter G: Human anti-self antibodies with high specificity from phage display libraries. EMBO J 12:725-734, 1993
29. Munro S, Pelham HRB: An Hsp 70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding. Cell 46:291-300, 1968
30. Lucocq JM, Roth J: Colloidal gold and colloidal silver-metallic markers for light microscopic histochemistry. In: Bullock GR, Petrusz P (eds). Techniques in Immunocytochemistry. Vol 3. Academic Press, New York, 1985, pp 203-236
31. Romano EL, Romano M: Staphylococcal protein A bound to colloidal gold: a useful reagent to label antigen-antibody sites in electron microscopy. Immunohistochemistry 14:711-715, 1977
32. Cournoyer D, Beauchemin N, Boucher D, Benchimol S, Fuks A, Stanner CP: Transcription of genes of the carcinoembryonic antigen family in malignant and nonmalignant human tissues. Cancer Res 48:3153-3257, 1988
33. Thompson J, Mössinger S, Reichardt V, Engels U, Beauchemin N, Kommoss F, von Kleist S, Zimmermann W. A Polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual CEA gene family members. Int J Cancer 55:311-319, 1993
34. Kurosumi K, Shibasaka S, Ito T: Cytology of the secretion in mammalian sweat glands. Int Rev Cytol 87:253-329, 1984
35. Strauss JS, Downing DT, Ebling FJ, Stewart ME: Sebaceous glands. In: Goldsmith LA (ed.). Physiology, Biochemistry, and Molecular Biology of the Skin. Oxford University Press, New York, 1991, pp 712-740
36. Bell M: A comparative study of the ultrastructure of the sebaceous glands of man and other primates. J Invest Dermatol 62:132-143, 1974
37. Hashimoto K, Gross BG, Lever WF: The ultrastructure of the skin of human embryos. I. The intraepidermal eccrine sweat duct. J Invest Dermatol 45:139-151, 1965
38. Metze D, Jurecka W, Gebhart W: Disseminated syringomas of the upper extremities. Case history, immunohistochemical and ultra structural study. Dermatologica 180:228-235, 1990
39. Holbrook KA: Structure and function of the developing human skin. In: Goldsmith LA (ed.). Physiology, Biochemistry, and Molecular Biology of the Skin, Oxford University Press, New York, 1991, pp 63-112
40. Von Kleist S, Winkler J, Migule I, Böhm N: Carcinoembryonic antigen (CEA) expression in early embryogenesis: a study of the first trimester of gestation. Anticancer Res 6:1265-1272, 1986
41. Hagemeier HH, Bhardwaj R, Grunert F, Buchegger F, Goerdt S, von Kleist S, Sorg C: Carcinoembryonic antigen and related glycoproteins in psoriasis. Pathobiology 61:19-24, 1993
42. Metze D, Bhardwaj R, Amann U, Artuc M, Grunert F, Luger T: Carcinoembryonic antigen (CEA): an adhesion molecule of the skin? In: Ishibashi Y, Nakagawa H, Suzuki H (eds.). Electron Microscopy in Dermatology - Basic and Clinical Research. Elsevier Science B. V., Amsterdam, 1994, pp 249-253
43. Baranov V, Yeung MMW, Hammarstrom S: Expression of carcinoembryonic antigen and nonspecific cross-reacting 50-kDa antigen in human normal and cancerous colon mucosa: Comparative ultrastructural study with monoclonal antibodies. Cancer Res 54:3305-3314, 1994
44. Williams R, Jiang GS, Holms K: Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins. Proc Natl Acad Sci USA 88:5533-5536, 1991
45. Metze D, Jurecka W, Gebhart W, Schmidt JB, Mainitz M, Niebauer G: Immunohistochemical demonstration of immunoglobulin A in human sebaceous and sweat glands. J Invest Dermatol 92:13-17, 1989
46. Okada T, Konishi H, Ito M, Nagura H, Asai J. Identification of secretory immunoglobulin A in human sweat and sweat glands. J Invest Dermatol 90:648-651, 1988
47. Metze D, Kersten A, Jurecka W, Gebhart W: Immunoglobulins coat microorganisms of skin surface: a comparative immunohistochemical and ultrastructural study of cutaneous and oral microbial symbionts. J Invest Dermatol 96:439-445, 1991
48. Imayama S, Shimozono Y, Hoashi M, Yasumoto S, Ohta S, Yoneyama K, Hori Y: Reduced secretion of IgA to skin surface of patients with atopic dermatitis. J Allergy Clin Immunol 94:195-200, 1994