Potent inhibitors of neutral endopeptidase. 2-biphenylmethylglutaric acid amide derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 1, 1996, Pages 65-70

  Kanno, Hideyuki ^a   Osanai, Ken ^a   Furugohri, Taketoshi ^a   Watanabe, Yoshifumi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(4 BIPHENYLYL)METHYL]GLUTARIC ACID AMIDE DERIVATIVE; CANDOXATRILAT; ENZYME INHIBITOR; MEMBRANE METALLOENDOPEPTIDASE; THIORPHAN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION;

EID: 0030049819     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(95)00551-4     Document Type: Article

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9. Separation of diastereoisomers was performed using a Chiral Pak AS column (2 cm, 30 cm) with 3.5% EtOH in hexane for elution at a flow rate of 5 mL per min.
10. Florentin, D.; Sassi, A.; Roques, B. P. Anal. Biochem. 1984, 141, 62.