Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo

Cancer Letters

Volumn 98, Issue 2, 1996, Pages 241-251

  Newell, S W ^a   Perchellet, E M ^a   Gao, X M ^a   Chen, G ^a   Perchellet, J P ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

Calyculin A; Hydroperoxide production; Mouse epidermis; Okadaic acid; Tumor promotion

Indexed keywords

4 BROMOPHENACYL BROMIDE; ANTIHISTAMINIC AGENT; ANTIINFLAMMATORY AGENT; CALCIUM ANTAGONIST; CALYCULIN A; CYCLOHEXIMIDE; DIPHENYLIODONIUM SALT; HYDROPEROXIDE; NORDIHYDROGUAIARETIC ACID; OKADAIC ACID; OXIPURINOL; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; THAPSIGARGIN; TUMOR PROMOTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPIDERMIS; FEMALE; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; TUMOR PROMOTION;

ANIMALIA;

EID: 0030048862     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(06)80038-8     Document Type: Article

References (39)

1. Suganuma, M., Fujiki, H., Suguri, H., Yoshizawa, S., Hirota, M., Nakayasu, M., Ojika, M., Wakamatsu, K., Yamada, K. and Sugimura, T. (1988) Okadaic acid: an additional nonphorbol-12-tetradecanoate-13-acetate-type tumor promoter. Proc. Natl. Acad. Sci. USA, 85, 1768-1771.
2. Suganuma, M., Fujiki, H., Suguri, H.F., Yoshizawa, S., Yasumoto, S., Kato, Y., Fusetani, N. and Sugimura, T. (1990) Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin. Cancer Res., 50, 3521-3525.
3. Gopalakrishna, R, Chen, Z.H. and Gundimeda, V. (1992) Nonphorbol tumor promoter okadaic acid and calyculin-A induce membrane translocation of protein kinase C. Biochem. Biophys. Res. Commun., 189, 950-957.
4. Wang, X.J., Warren, B.S., Rupp, T., Beltran, L.M. and Di-Giovanni, J. (1994) Loss of mouse epidermal protein kinase C isozyme activities following treatment with phorbol ester and non-phorbol ester tumor promoters. Carcinogenesis, 15, 2795-2803.
5. Ishahara, H., Martin, B.L., Brautigan, D.L., Haraki, H., Ozaki, H., Kato, Y., Fusetani, N., Watanabe, S., Hashimoto, K., Uemura, D. and Hartshorne, D.J. (1989) Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem. Biophys. Res. Commun., 159, 871-877.
6. Herschman, H.R., Lim, R.W., Brankow, D.W. and Fujiki, H. (1989) The tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid differ in toxicity, mitogenic activity and induction of gene expression. Carcinogenesis, 10, 1495-1498.
7. Medcalf, R.L. (1992) Cell- and gene-specific interactions between signal transduction pathways revealed by okadaic acid. J. Biol. Chem., 267, 12220-12226.
8. Perchellet, J.P. and Perchellet, E.M. (1989) Antioxidants and multistage carcinogenesis in mouse skin. Free Rad. Biol. Med., 7, 377-408.
9. Perchellet, J.P., Perchellet, E.M., Gali, H.U. and Gao, X.M. (1995) Oxidant stress and multistage skin carcinogenesis. In: Skin Cancer: Mechanisms and Human Relevance, pp. 145-180. Editor: H. Mukhtar. CRC Press, Boca Raton, FL.
10. Perchellet, E.M., Abney, N.L. and Perchellet, J.P. (1988) Stimulation of hydroperoxide generation in mouse skins treated with tumor-promoting or carcinogenic agents in vivo and in vitro. Cancer Lett., 42, 169-177.
11. Perchellet, E.M. and Perchellet, J.P. (1989) Characterization of the hydroperoxide response observed in mouse skin treated with tumor promoters in vivo. Cancer Res., 49, 6193-6201.
12. Reiners, J.J., Pence, B.C., Barcus, M.C.S. and Cantu, A.R. (1987) 12-O-Tetradecanoylphorbol-13-acetate-dependent induction of xanthine dehydrogenase and conversion to xanthine oxidase in murine epidermis. Cancer Res., 47, 1775-1779.
13. Trenam, C.W., Blake, D.R. and Morris, C.J. (1992) Skin inflammation: reactive oxygen species and the role of iron. J. Invest. Dermatol., 99, 675-682.
14. Fischer, S.M., Baldwin, J.K., Jasheway, D.W., Patrick, K.E. and Cameron, G.S. (1988) Phorbol ester induction of 8-lipoxygenase in inbred SENCAR (SSIN) but not C57BL/6J mice correlated with hyperplasia, edema and oxidant generation but not ornithine decarboxylase induction. Cancer Res., 48, 658-664.
15. Fischer, S.M., Patrick, K.E., Patamalai, B. and Slaga, T.J. (1990) Effects of antihistamines on phorbol ester tumor promotion and vascular permeability changes. Carcinogenesis, 11, 991-996.
16. Fischer, S.M. (1995) Eicosanoids and tumor promotion. In: Skin Cancer: Mechanisms and Human Relevance, pp. 129-143. Editor: H. Mukhtar. CRC Press, Boca Raton, FL.
17. Gali, H.U., Perchellet, E.M., Klish, D.S., Johnson, J.M. and Perchellet, J.P. (1992) Hydrolyzable tanins: potent inhibitors of hydroperoxide production and tumor promotion in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate in vivo. Int. J. Cancer, 51, 425-432.
18. Gao, X.M., Perchellet, E.M., Chen, G., Newell, S.W. and Perchellet, J.P. (1994) Characterization of the tumor-promoting activity of thapsigargin in CF-1 mouse skin. Int. J. Oncol., 5, 793-803.
19. Perchellet, E.M., Gali, H.U., Gao, X.M. and Perchellet, J.P. (1993) Ability of the non-phorbol-ester type tumor promoter thapsigargin to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on ornithine decarboxylase activity, hydroperoxide production and macromolecule synthesis in mouse epidermis in vivo. Int. J. Cancer, 55, 1036-1043.
20. 2+ ionophores A23187 and ionomycin to mimic some of the effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production, ornithine decarboxylase activity, and DNA synthesis in mouse epidermis in vivo. Cancer Res., 50, 5806-5812.
21. Nishiwaki, S., Fujiki, H., Suganuma, M., Furuya-Suguri, H., Matsushima, R., Iida, Y., Ojika, M., Yamada, K., Uemura, D., Yasumoto, T., Schmitz, F.J. and Sugimura, T. (1990) Structure-activity relationship within a series of okadaic acid derivatives. Carcinogenesis, 11, 1837-1841.
22. Yoshizawa, S., Matsushima, R., Watanabe, M.F., Harada, K., Ichihara, A., Carmichael, W. and Fujiki, H. (1990) Inhibition of protein phosphatases by microcystins and nodularin associated with hepatoxicity. J. Cancer Res. Clin. Oncol., 116, 609-614.
23. MacKintosh, C. and Klumpp, S. (1990) Tautomycin from Streptomyces verticillatus another potent and specific inhibitor of protein phosphatases 1 and 2A. FEBS Lett., 277, 137-140.
24. Li, Y.M. and Casida, J.E. (1992) Cantharidin-binding protein: identified as protein phosphatase 2A. Proc. Natl. Acad. Sci. USA, 89, 11867-11870.
25. Enan, E. and Matsmura, F. (1992) Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides. Biochem. Pharmacol., 43, 1777-1781.
26. 2 activation: potentiation by vanadate. Biochem. J., 295, 879-888.
27. Fujiki, H., Suganuma, M., Nishiwaki, S., Yoshizawa, S., Yatsunami, J., Matsushima, R., Furuya, H., Okabe, S., Matsunaga, S. and Sugimura, T. (1992) Specific mechanistic aspects of animal tumor promoters: the okadaic acid pathway. In: Relevance of Animal Studies to the Evaluation of Human Cancer Risk, pp. 337-350. Editors: R. D'Amato, T.J. Slaga, W.H. Farland and C. Henry. Wiley-Liss, New York.
28. Kano, S., Iisuka, T., Ishimura, Y., Fujiki, H. and Sugimura, T. (1987) Stimulation of superoxide anion formation by the non-TPA-type tumor promoters palytoxin and thapsigargin in porcine and human neutrophils. Biochem. Biophys. Res. Commun., 143, 672-677.
29. Suganuma, M., Yatsunami, J., Yoshizawa, S., Okabe, S. and Fujiki, H. (1993) Absence of synergistic effects on tumor promotion in CD-1 mouse skin by simultaneous applications of two different types of tumor promoters, okadaic acid and teleocidin. Cancer Res., 53, 1012-1016.
30. Nam, K.-Y., Hiro, M., Kimura, S., Fujiki, H. and Imanishi, Y. (1990) Permeability of a non-TPA-type tumor promoter, okadaic acid, through lipid bilayer membrane. Carcinogenesis, 11, 1171-1174.
31. Takeuchi, T., Nakajima, M. and Morimoto, K. (1994) Calyculin A, a non-phorbol ester type tumor promoter, induced oxidative DNA damage in stimulated human neutrophil-like cells. Biochem. Biophys. Res. Commun., 205, 1803-1807.
32. Yamaguchi, M., Sasaki, J.-I., Kuwana, M., Sakai, M., Okamura, H. and Ishibashi, S. (1993) Cytosolic protein phosphatase may turn off activated NADPH oxidase in guinea pig neutrophils. Arch. Biochem. Biophys., 306, 209-214.
33. Ding, J. and Badwey, J.A. (1992) Effects of antagonists of protein phosphatases on superoxide release by neutrophils. J. Biol. Chem., 267, 6442-5448.
34. 2 activation by phosphorylation in mouse peritoneal macrophages. J. Biol. Chem., 268, 24506-24513.
35. Marks, F., Hanke, B., Thastrup, O. and Fürstenberger, G. (1991) Stimulatory effects of thapsigargin, a non-TPA-type tumor promoter, on arachidonic acid metabolism in the murine keratinocyte line HEL30 and on epidermal-cell proliferation in vivo as compared to the effects of the phorbol ester TPA. Carcinogenesis, 12, 1491-1497.
36. Steinbeck, M.J., Hegg, G.G. and Karnovsky, M.J. (1991) Arachidonate activation of the neutrophil NADPH-oxidase: synergistic effects of potent phosphatase inhibitors compared with protein kinase activators. J. Biol. Chem., 266, 16336-16342.
37. Henderson, L.M., Moule, S.K. and Chappell, J.B. (1993) The immediate activator of the NADPH oxidase is arachidonate not phosphorylation. Eur. J. Biochem., 211, 157-162.
38. Yoon, H.L., Marcus, C.B. and Pfeifer, R.W. (1993) Induction of superoxide by 12-O-tetradecanoylphorbol-13-acetate and thapsigargin, a non-phorbol-ester-type tumor promoter, in peritoneal macrophages elicited from SENCAR and B6C3F1 mice: a permissive role for the arachidonic acid cascade in signal transduction. Mol. Carcinogen., 7, 116-125.
39. Watanabe, T., Tagudi, Y., Sasaki, K., Tsuyawa, K. and Kitamura, Y. (1981) Increase in histidine decarboxylase activity in mouse skin after application of the tumor promoter tetradecanoyl phorbol acetate. Biochem. Biophys. Res. Commun., 100, 427-432.