Bolus mitomycin C and 5-FU with sequential radiation for poor-prognosis locally advanced cervical cancer

Gynecologic Oncology

Volumn 60, Issue 1, 1996, Pages 64-71

  Denehy, Thad R ^a   Eastman, Ralph ^a   Sanfilippo, Louis ^a   Gregori, Caterina A ^a   Breen, James L ^a  

^a SAINT BARNABAS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; MITOMYCIN C;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; DOSE RESPONSE; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MUCOSA INFLAMMATION; NEUTROPENIA; PRIORITY JOURNAL; PROCTITIS; PROGNOSIS; RADIATION ENTEROPATHY; RADIATION INJURY; THROMBOCYTOPENIA; TREATMENT OUTCOME; UTERINE CERVIX CARCINOMA;

EID: 0030048683     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1006/gyno.1996.0013     Document Type: Article

References (21)

1. Perez, C. A., Bedwinek, J. M., and Breaux, S. R. Patterns of failure after treatment of gynecologic tumors, Cancer Treat. Symp. II, 217-231 (1983).
2. Moertel, C. G., Child, D. L., Rettemeier, R. J., Colby, M. Y., and Holbrook, M. A. Combined 5-fluorouracil and supervoltage radiation therapy in locally resectable gastrointestinal cancer, Lancet 2, 865 (1969).
3. Ansfield, F. J., Ramirez, G., Davis, H. L., Korbitz, B. C., Vemund, H., and Gollin, F. F. Advanced cancer of the head and neck treated with radiotherapy alone or combined with 5-fluorouracil, Cancer 25, 78 (1970).
4. Cohen, J. L., Krant, K. J., Shnider, B. E., Matias, P. I., Horton, J., and Baxter D. Radiation plus 5-fluorouracil (NSC-19893): Clinical demonstration of an effective bronchogenic carcinoma regimen, Cancer Chemother. Rep. 5, 253-258 (1971).
5. Byfield, J. E., Barone, R., Mendelsohn, J., Frankel, S., Quinol, L., Sharp, T., and Seagren, S. Infusional 5-fluorouracil and x-ray therapy for nonresectable esophageal cancer, Cancer 45, 703-708 (1980).
6. Nigro, N. D., Vaitkevicius, V. K., Considine, B., Jr. Combined therapy for cancer of the anal canal: A preliminary report, Dis. Colon Rectum 17, 354-356 (1974).
7. Matthew, C. P., Mitomycin-C combined with radiotherapy in the management of cervical carcinoma - A preliminary report on 251 consecutive cases, Ind. J. Cancer 13, 39-43 (1976).
8. Quan, S. H. Q., Magill, G. B., Learning, R. H., and Hajdu, S. I. Multidisciplinary preoperative approach to the management of epidermoid carcinoma of the anus and anorectum. Dis. Colon Rectum 21, 89-91 (1978).
9. Michaelson, R. A., Magill, G. B., Quan, S. H. Q., Leaming, R. H, Nikruim, M., and Stearns, M. W. Preoperative chemotherapy and radiation therapy in the management of anal epidermoid carcinoma, Cancer 51, 390-395 (1983).
10. Secco, G. B., Sertoli, M. R., Scarpati, D., Marino, G., Fardelli, R., Nobila, M. T., and Corro, R. Preoperative chemotherapy and radiotherapy in the management of epidermoid carcinoma of the anal canal, Tumori 73, 151-155 (1987).
11. Byfield, J. E., Calabro-Jones, C., Klisak, I., and Kulhanian, F. Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-fluorouracil or fluorouracil and X rays, Int. J. Radiat. Oncol. Biol. Phys. 8, 1923-1931 (1982).
12. Thomas, G., Dembo, A., Beale, F., Bean, H., Bush, R., Herman, J., Pringel, J., Rawlings, G., Sturgeon, J., Fine, S., and Black, B. Concurrent radiation, mitomycin-C and 5-fluorouracil in carcinoma of the cervix, Int. J. Radiat. Oncol. Phys. 10, 1785-1790 (1984).
13. Khoury, G. G., Bulman, A. S., Joslin, C. A. F., and Rothwell, R. I. Concomitant pelvic irradiation, 5-fluorouracil and mitomycin C in the treatment of advanced cervical carcinoma, Br. J. Radiol. 64, 252-260 (1991).
14. Thomas, G., Dembo, A., Fyles, A., Gadalla, T., Beale, F., Bean, H., Pringle, J., Rawlings, G., Bush, R., and Black, B. Concurrent chemoradiation in advanced cervical cancer, Gyn. Oncol. 38, 446-451 (1990).
15. Evans, L., Kersh, C. R., Constable, W. C., and Taylor, P. T. Concomitant 5-fluorouracil, mitomycin-C and radiotherapy for advanced gynecologic malignancies, Int. J. Radiat. Oncol. Biol. Phys. 15, 901-906 (1988).
16. Ludgate, S. M., Crandon, A. J., Hudson, C. N., Walker, Q., and Langlands, A. O. Synchronous 5-fluorouracil, mitomycin-C and radiation therapy in the treatment of locally advanced carcinoma of the cervix, Int. J. Radiat. Oncol. Phys. 15, 893-899 (1988).
17. Kersh, C. R., Constable, W. C., Spaulding, C. A., Hahn, S. S., Andersen, W. A., and Taylor, P. T. A phase I-II trial of multimodality management of bulky gynecologic malignancy: Combined chemoradiosensitization and radiotherapy, Cancer 66, 30-34 (1990).
18. John, M., Flam, M., Sikic, B., Rotman, M., Cooper, J., Malec, M., Hannigan, J., and Phillips, T. Preliminary results of concurrent radiotherapy and chemotherapy in advanced cervical carcinoma: A phase I-II prospective intergroup NCOG-RTOG study, Gyn. Oncol. 37, 1-5 (1990).
19. Nguyen, P. D., Berchamns, J., Munoz, A. K., Yazigi, R., Graham, M., and Franklin, P. Mitomycin-C/5-FU and radiation therapy for locally advanced cervical cancer, Gyn. Oncol. 43, 220-225 (1991).
20. Rockwell, S., and Kennedy, K. A. Combination therapy and mitomycin-C: Preliminary results with EMT6 tumor cells in vitro and in vivo, Int. J. Radiat. Oncol. Biol. Phys. 5, 1673-1976 (1979).
21. Rockwell, S., Effects of mitomycin-C alone and in combination with x-rays on EMT6 mouse mammary tumors in vivo, JNCI 71, 765-771 (1983).