Exocrine function of caerulein-induced acute pancreatitis in anesthetized rats

Journal of Gastroenterology

Volumn 31, Issue 1, 1996, Pages 94-99

  Sata, Naohiro ^a   Kimura, Wataru ^a   Muto, Tetsuichiro ^a   Mineo, Chieko ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

Author keywords

Acute pancreatitis; Caerulein pancreatitis; Exocrine function; Pure pancreatic juice

Indexed keywords

AMYLASE; CERULETIDE; PROTEIN; TRYPSIN;

ACUTE PANCREATITIS; AMYLASE RELEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; EDEMA; ELECTROPHORESIS; ENZYME ACTIVITY; EXOCRINE SECRETION; HISTOLOGY; MALE; NONHUMAN; PANCREAS JUICE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION; RAT;

ACUTE DISEASE; ANIMALS; CAERULEIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; PANCREAS; PANCREATIC JUICE; PANCREATITIS; RATS; RATS, WISTAR; TRYPSIN;

EID: 0030048571     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01211193     Document Type: Article

References (22)

1. Lampel M, Kern HF. Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue. Virchows Arch [A] 1977;373:97-117.
2. Adler G, Hupp T, Kern HF. Course and spontaneous regression of acute pancreatitis in the rat. Virchows Arch [A] 1979;382: 31-47.
3. Adler G, Rohr G, Kern HF. Alteration and membrane fusion as a course of acute pancreatitis in the rat. Dig Dis Sci 1982;27: 993-1002.
4. Bieger W, Martin-Achard A, Bassler M, Kern HF. Studies on intracellular transport of secretory proteins in the rat exocrine pancreas. Cell Tiss Res 1976;165:435-453.
5. Scheele G, Adler G, Kern HF. Exocytosis occurs at the lateral plasma membrane of the pancreatic acinar cell during supramaximal secretagogue stimulation. Gastroenterology 1987;92: 345-353.
6. Peterson H, Grossman MI. pancreatic exocrine secretion in anesthetized and conscious rats. Am J Physiol 1977;233:E530-E536.
7. Renner IG, Wisner JR. Protective effects of exogenous secretin on ceruletide-induced acute pancreatitis in the rat. J Clin Invest 1983;72:1081-1092.
8. Renner IG, Wisner JR, Lavigne BC. Partial restoration of pancreatic function by exogenous secretin in rats with ceruletide-induced acute pancreatitis. Dig Dis Sci 1986;31:305-313.
9. Kawabata S, Miura T, Morita T, et al. Highly sensitive peptide-4-methylcoumaryl-7-amide substrates for blood-clotting proteases and trypsin. Eur J Biochem 1988;172:17-25.
10. Satake K, Hiura A, Ha SS, et al. Effect of a new synthetic protease inhibitor on beta-endorphin release during acute pancreatitis in dogs. Pancreas 1991;6:441-447.
11. Bernfeld P. α-amylase. Methods Enzymol 1955;1:149-151
12. Smith PK, Krohn RI, Hermanson GT, et al. Measurement of protein using bicinchoninic acid. Anal Biochem 1985;150:76-85.
13. Keim V, Adler G, Habench FJ, Kern HF. Failure of secretin to prevent or ameliorate caerulein-induced pancreatitis in the rat. Hepato-gastroenterol 1985;32:91-96.
14. Wisner JR, Ozawa S, Renner IG. Pancreatic exocrine function in unconscious rats treated with submaximal, maximal, and supramaximal doses of bombesin tetradecapeptide. Pancreas 1989;4:83-89.
15. Manso MA, San Roman JI, Dios I, et al. Cerulein-induced acute pancreatitis in the rat. Study of pancreatic secretion and plasma VIP and secretin levels. Dig Dis Sci 1992;37:364-368.
16. Renner IG, Rinderknecht H, Douglas AP. Profiles of pure pancreatic secretion in patients with acute pancreatitis: The possible role of proteolytic enzymes in pathogenesis. Gastroenterology 1978;75:1090-1098.
17. Allan J, White TT, An alternative mechanism for the formation of protein plugs in chronic calcifying pancreatitis. Digestion 1974;11:428-431.
18. Miczczuk-Jamaka B, Guy O, Figarella C. A1-proteinase inhibitor in pure human pancreatic juice. Hoppe Seyler's Z Physiol Chem 1983;364:509-513.
19. Figarella C, Amouric M, Guy-Crotte O. Role of lysosome in pancreatic diseases. Int J Pancreatol 1988;3:S9-S18.
20. Yamaguchi H, Kimura T, Mimura K, Nawata H. Activation of proteases in caerulein-induced pancreatitis. Pancreas 1989;4: 565-571.
21. Bialek R, Willemer S, Arnord R, Adler G, Evidence of intracellular activation of serine-proteases in acute pancreatitis in rats. Scand J Gastroenterol 1991;26:190-196.
22. Leach SD, Modlin M, Scheele GA, Gorelick FS. Intracellular activation of digestive zymogens in rat pancreatic acini stimulated by high dose of cholecystokinin. J Clin Invest 1991;26:190-196.