Continuing search for solutions to trauma associated infections

Journal of the Royal College of Surgeons of Edinburgh

Volumn 41, Issue 1, 1996, Pages 1-6

  Polk Jr , H C ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE HOSPITAL   (United States)

Author keywords

Infections; Injuries; Lister; Pneumonia; Trauma

Indexed keywords

ANTIBIOTIC AGENT; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MURAMYL DIPEPTIDE; TUMOR NECROSIS FACTOR ALPHA;

CAUSE OF DEATH; CLINICAL TRIAL; DATA ANALYSIS; HOST RESISTANCE; HUMAN; INFECTION CONTROL; LABORATORY; NONHUMAN; PNEUMONIA; SHORT SURVEY; SUBCUTANEOUS DRUG ADMINISTRATION; SURGICAL INFECTION; SURGICAL PATIENT; TREATMENT OUTCOME;

ANTI-BACTERIAL AGENTS; CLINICAL TRIALS; CROSS INFECTION; HUMANS; INTERFERON TYPE II; PNEUMONIA, BACTERIAL; POSTOPERATIVE COMPLICATIONS; RESPIRATORY DISTRESS SYNDROME, ADULT; SEPSIS; SURGICAL PROCEDURES, ELECTIVE; SURGICAL WOUND INFECTION; WOUND INFECTION;

EID: 0030048376     PISSN: 00358835     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (29)

1. Miles AA, Miles EM, Burke J. The value and duration of defense reactions of the skin to the primary lodgement of bacteria. Br J Exp Pathol 1957; 38: 79-96.
2. Polk HC Jr, Lopez-Mayor JF. Postoperative wound infection: a prospective study of determinant factors and prevention. Surgery 1969; 66: 97-103.
3. Fulton RL, Jones CE. The cause of posttraumatic pulmonary insufficiency in mail. Surg Gynecol Obstet 1975; 140: 179-86
4. Alexander JW, Meakins JL. Natural defence mechanisms in clinical sepsis. J Clin Res 1971, 11: 148-61.
5. Ayala A, Perrin MM, Chaudry IH. Defective macrophage antigen presentation following haemorrhage is associated with the loss of MHC class II (Ia) antigens. Immunology 1990; 70: 33-9.
6. Ertel W, Meldrum DR, Morrison MH, Ayala A, Chaudry IH. Immunoprotective effect of a calcium channel blocker on macrophage antigen presentation function, major histocompatibility class II antigen expression, and interleukin-1 synthesis after hemorrhage. Surgery 1990; 108: 154-60.
7. Grbic JT, Mannick JA, Gough DB, Rodrick ML. The role of prostaglandin E2 in immune suppression following injury. Ann Surg 1991; 214: 253-63.
8. Horgan AF, Mendez MV, O'Riordian DS, Holzheimer RG, Mannick JA, Rodrick ML. Altered gene transcription after burn injury results in depressed T-lymphocyte activation. Ann Surg 1994; 220. 342-52.
9. Simms HH, D'Amico R, Burchard KW. Intraabdominal sepsis-enhanced autooxidative effect on polymorphonuclear leukocyte cell surface receptor expression. Circ Shock 1991; 34: 356-63.
10. Polk HC Jr. The enhancement of host defenses against infection: Search for the holy grail? Surgery 1986; 99: 1-6.
11. Garrison RN, Shively EH, Baker C, Steele M, Trunkey D, Polk HC Jr. Evaluation of management of the emergency right hemicolectomy. J Trauma 1979; 19: 734-39.
12. Polk HC Jr, George CD, Wellhausen SR et al. A systematic study of host defense processes in badly injured patients. Ann Surg 1986; 204: 282-99.
13. Hershman MJ, Cheadle WG, Wellhausen SR, Davidson PF, Polk HC Jr. Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient. Br J Surg 1990; 77: 204-7.
14. Hershman MJ, Appel SH, Wellhausen SR, Sonnenfeld G, Polk HC Jr Interferon-gamma treatment increases HLA-DR expression on monocytes in severely injured patients Clin Exp Immunol 1989; 77: 67-70.
15. Hershman MJ, Pietsch JD, Trachtenberg L, Mooney THR, Shields RE, Sonnenfeld G. Protective effects of recombinant human tumour necrosis factor alpha and interferon gamma against surgically simulated wound infection in mice. Br J Surg 1989; 76: 1282-86.
16. Livingston DH, Malangoni MA, Interferon-γ restores immune consequences after hemorrhagic shock. J Surg Res 1988; 45: 37-43.
17. Polk HC Jr, Cheadle WG, Livingston DH et al. A randomized prospective clinical trial to determine the efficacy of interferon-gamma in severely injured patients. Am J Surg 1992; 163: 191-96.
18. Dries DJ, Jurkovich GJ, Maier RV et al. Effect of interferon gamma on infection-related deaths in patients with severe injuries: a randomized, double-blind, placebo-controlled trial. Arch Surg 1994, 129: 1031-41.
19. Hadjiminas D, Cheadle WG, Spain DA et al. Antibiotic overkill in the trauma victim? Am J Surg 1994; 168: 288-90
20. Gaar E, Naziri W, Cheadle WG, Pietsch JD, Johnson M, Polk HC Jr. Improved survival in simulated surgical infection with combined cytokine, antibiotic and immunostimulant therapy. Br J Surg 1994, 81: 1309-11.
21. Martin UP, Asher EF, Casey JM et al. Postoperative pneumonia: determinants of mortality. Arch Surg 1984; 119: 379-83.
22. Naziri W, Cheadle WG, Pietsch JD, Appel S, Polk HC Jr. Pneumonia in the surgical intensive care unit: immunologic keys to the silent epidemic. Ann Surg 1994; 219: 632-42.
23. Malangoni MA, Crafton R, Mocek FC. Pneumonia in the surgical intensive care unit: factors determining successful outcome. Am J Surg 1994; 167: 250-55.
24. Fujita T, Sakurai K. Multivariate analysis of risk factors for postoperative pneumonia. Am J Surg 1995; 169: 304-7.
25. Greenman RL, Schein RM, Martin MA et al. A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. JAMA 1991; 266: 1097-102.
26. Ziegler EJ, Fisher CJ Jr, Sprung SL et al. Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. N Engl J Med 1991; 324: 429-36.
27. Hanasawa K, Tani T, Kodama M. New approach to endotoxin and septic shock by means of polymyxin B immobilized fiber. Surg Gynecol Obstet 1989; 168: 323-31
28. Cheadle WG, Hanasawa K, Gallinaro RN, Nimmanwudipong T, Kodama M, Polk HC Jr. Endotoxin filtration and immune stimulation improves survival from gram-negative sepsis. Surgery 1991; 110: 785-92.
29. Aoki H, Kodama M, Tani T, Hanasawa K. Treatment of sepsis by extracorporeal elimination of endotoxin using polymyxin B-immobilized fiber. Am J Surg 1994; 167: 412-17