Uncoupling mechanism of glycoside antibiotic aculeximycin in isolated rat-liver mitochondria

Journal of Biochemistry

Volumn 119, Issue 2, 1996, Pages 274-280

  Miyoshi, Hideto ^a   Tamaki, Motohito ^a   Murata, Hideaki ^b   Ikemoto, Takaya ^c   Shibuya, Toshiro ^c   Harada, Ken Ichi ^b   Suzuki, Makoto ^b   Iwamura, Hajime ^a  

^a KYOTO UNIVERSITY   (Japan)

^b MEIJO UNIVERSITY   (Japan)

^c TEIKYO UNIVERSITY   (Japan)

Author keywords

Antibiotic (aculeximycin); Mitochondria (rat liver); Oxidative phosphorylation; Uncoupling

Indexed keywords

ACULEXIMYCIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; CINCHOCAINE; N ETHYLMALEIMIDE; POTASSIUM ION; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SODIUM ION;

ANIMAL TISSUE; ARTICLE; DRUG INHIBITION; DRUG MECHANISM; LIVER MITOCHONDRION; MALE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; POTASSIUM TRANSPORT; PROTON TRANSPORT; RAT; SODIUM TRANSPORT;

ANIMALIA;

EID: 0030048372     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021235     Document Type: Article

References (24)

1. Ikemoto, T., Katayama, T., Shiraishi, A., and Haneishi, T. (1983) Aculeximycin, a new antibiotic from Streptosporangium albidum. J. Antibiot. 36, 1097-1100
2. Murata, H., Kojima, N., Harada, K., Suzuki, M., Ikemoto, T., Shibuya, T., Haneishi T., and Torikata, A. (1989) Structural elucidation of aculeximycin: Further purification and glycoside bond cleavage of aculeximycin. J. Antibiot. 42, 691-700
3. Murata, H., Suzuki, K., Tabayashi, T., Hattori, C., Takeda, Y., Harada, K., Suzuki, M., Ikemoto, T., Shibuya, T., Haneishi, T., Torikata, A., Itezono, Y., and Nakayama, N. (1995) Structural elucidation of aculeximycin: Planar structure of aculeximycin, belonging to a new class of macrolide antibiotics. J. Antibiot. 48, 838-849
4. Murata, H., Ohama, I., Harada, K., Suzuki, M., Ikemoto, T., Shibuya, T., Haneishi, T., Torikata, A., Itezono, Y., and Nakayama, N. (1995) Structural elucidation of aculeximycin: Absolute structure of aculeximycin, belonging to a new class of macrolide antibiotics. J. Antibiot. 48, 850-862
5. Myers, D.K. and Slater, E.C. (1957) The enzymatic hydrolysis of adenosine triphosphate by liver mitochondria. Biochem. J. 67, 558-572
6. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951) Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 262-275
7. Kamo, N., Muratsugu, M., Hongoh, R., and Kobayashi, Y. (1979) Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state. J. Membr. Biol. 49, 105-121
8. 2+ by mitochondria. J. Biol. Chem. 255, 8663-8671
9. 2+ in rat liver mitochondria. Biochim. Biophys. Acta 1060, 75-81
10. Nishimura, M., Ito, T., and Chance, B. (1962) Studies on bacterial photophosphorylation: A sensitive and rapid method of determination of photophosphorylation. Biochim. Biophys. Acta 59, 177-182
11. Terada, H. (1981) The interaction of highly active uncouplers with mitochondria. Biochim. Biophys. Acta 639, 225-242
12. Benz, R. and McLaughlin, S. (1983) The molecular mechanism of action of the proton ionophore FCCP. Biophys. J. 41, 381-398
13. Bernardi, P., Vassanelli, S., Veronese, P., Colonna, R., Szabo, I., and Zoratti, M. (1992) Modulation of the mitochondrial permeability transition pore. J. Biol. Chem. 267, 2934-2939
14. Fonyo, A. (1981) Inhibitors of mitochondrial phosphate transport in Inhibitors of Mitochondrial Functions (Erecinska, M. and Wilson, D.F., eds.) pp. 261-281, Pergamon Press, Oxford
15. Miyoshi, H., Tsujishita, H., Tokutake, N., and Fujita, T. (1990) Quantitative analysis of uncoupling activity of substituted phenols with physicochemical substituent and molecular parameters. Biochim. Biophys. Acta 1016, 99-106
16. Guo, Z.J., Miyoshi, H., Komyoji, T., Haga, T., and Fujita, T. (1991) Quantitative analysis with physicochemical substituent and molecular parameters of uncoupling activity of substituted diarylamines. Biochim. Biophys. Acta 1059, 91-98
17. Moreno, S.N.J., Gadelha, F.R., and Docampo, R. (1988) Crystal violet as an uncoupler of oxidative phosphorylation in rat liver mitochondria. J. Biol. Chem. 263, 12493-12499
18. Terada, H., Shima, O., Yoshida, K., and Shinohara, Y. (1990) Effects of the local anesthetic bupivacaine on oxidative phosphorylation in mitochondria. J. Biol. Chem. 265, 7837-7842
19. 2+ efflux from mitochondria by nupercaine and tetracaine. Nature 277, 484-486
20. Lin, C.T., Williamson, L.N., Chyan, Y.G., and Margues, A.D.S. (1988) Deprotonation dynamics of local anesthetics in hydrophobic media: Dibucaine in water/alcohol or surfactant mixtures. Photochem. Photobiol. 48, 733-740
21. 2+-induced swelling of mitochondria by cyclosporin A is probably caused by inhibitor binding to mitochondrial matrix peptidyl prolyl cis trans isomerase and preventing its binding to the adenine nucleotide translocase. Biochem. J. 268, 153-160
22. 2+ overload by inhibiting a matrix peptidyl prolyl cis trans isomerase. Biochem. J. 274, 611-614
23. Novgorodov, S.A., Gudz, T.I., Jung, D.W., and Brierley, G.P. (1991) The nonspecific inner membrane pore of liver mitochondria; modulation of cyclosporin sensitivity by ADP at carboxy-atractyloside-sensitive and insensitive sites. Biochem. Biophys. Res. Commun. 180, 33-38
24. 2+ dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem. J. 255, 357-360