A common epitope on platelet integrin αIIbβ3 (glycoprotein IIbIIIa; CD41b/CD61) and αMβ2 (Mac-1; CDIIb/CD18) detected by a monoclonal antibody

Journal of Immunology

Volumn 156, Issue 1, 1996, Pages 284-288

  De Nichilo, Mark O ^a   Shafren, Darren R ^a   Carter, Wendy M ^b   Berndt, Michael C ^c   Burns, Gordon F ^a   Boyd, Andrew W ^b,d  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^d ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; CELL SURFACE RECEPTOR; EPITOPE; FIBRINOGEN RECEPTOR; INTEGRIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCLONAL ANTIBODY; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; CROSS REACTION; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; THROMBOCYTE;

ANTIBODIES, MONOCLONAL; BINDING SITES, ANTIBODY; CELL LINE; EPITOPES; HUMANS; MACROPHAGE-1 ANTIGEN; MACROPHAGES; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX;

EID: 0030048336     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Hynes, R. O. 1992. Integrins: versatility, modulation and signaling in cell adhesion Cell 69:11.
2. Hemler, M. E. 1990 VLA proteins in the integrin family structures, functions, and their role on leukocytes. Annu. Rev. Immunol. 8:365.
3. Krissansen, G. W., M. J. Elliott, C. M. Lucas, F. C. Stomski, M. C. Berndt, D. A. Cheresh, A F. Lopez, and G. F. Burns. 1990. Identification of a novel integrin β subunit expressed on cultured monocytes (macrophages). Evidence that one α subunit can associate with multiple β subunits. J. Biol. Chem. 265:823.
4. Horton, M. A , D Lewis, K. McNulty, J. A. S. Pringle, and T. J Chambers. 1985. Monoclonal antibodies to osteoclastomas (giant bone cell tumors): definition of osteoclast-specific antigens. Cancer Res. 45.5663.
5. Cheresh, D. A , and R. C. Spiro. 1987. Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen and von Willebrand factor. J. Biol. Chem. 262:17703.
6. Frelinger, A. L., III, I Cohen, E Plow, M. A. Smith, J Roberts, S C. Lam, and M. H. Ginsberg. 1990 Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. J. Biol. Chem 265:6346.
7. Davies, J., J. Warwick, N. Totty, R Philip, M. Helfrich, and M. Horton. 1990. The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J. Cell Biol 109:1817.
8. 1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos. EMBO J. 10:2375.
9. Moyle, M., M. A. Napier, and J. W. McLean 1991 Cloning and expression of a divergent integin subunit β8. J Biol. Chem. 266:19650
10. ++ binding epitope on leukocyte integrin α subunits EMBO J 8:3759
11. Altien, D C., and T. S. Edgington 1988 A monoclonal antibody reacting with distinct adhesion molecules defines a transition in the functional state of the receptor CD11b/CD18 (Mac-1). J. Immunol 141.2656.
12. Dransfield, I , C. Cabanas, J. Barrett, and N Hogg. 1992. Interaction of leukocyte integrins with ligand is necessary but not sufficient for function. J. Cell Biol. 116:1527.
13. Burns, G. F., L Cosgrove, T. Triglia, J. A. Beall, A. F. Lopez, J. A. Werkmeister, C. G. Begley, A. P. Haddad, A. J. F. d'Apice, M. A. Vadas, and J. C. Cawley. 1986 The IIb-IIIa glycoprotein complex that mediates platelet aggregation is directly implicated in leukocyte adhesion. Cell 45:269.
14. Krissansen, G. W., C. M. Lucas, F. C. Stomski, M. J. Elliott, M. C. Berndt, A. W. Boyd, M. A. Horton, D. A. Cheresh, M. A. Vadas, and G. F. Burns 1990. Blood leukocytes bind platelet glycoprotein (IIb-IIIa) but do not express the vitronectin receptor. Int Immunol. 2:267.
15. Fournier, D. J., A Kabral, P. A. Castaldi, and M C. Berndt. 1989. A variant of Glanzmann's thrombasthenia characterized by abnormal glycoprotein IIb/IIIa complex formation. Thromb. Haemost. 62:977.
16. Stacker, S A , and T. A. Springer. 1991. Leukocyte integrin p150/95 (CD11c/CD18) functions as an adhesion molecule binding to a counter-receptor on stimulated endothelium. J. Immunol. 146:648.
17. Aruffo, A., and B. Seed. 1987. Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Proc. Natl. Acad. Sci. USA 84 8573
18. Larson, R. S., A. L. Corbi, L. Berman, and T. Springer. 1989 Primary structure of the leukocyte-function associated molecule-1 α subunit: an integrin with an embedded domain defining a protein superfamily. J. Cell Biol. 108:703.
19. Hibbs, M L., A. L. Wardlaw, S A. Stacker, D. C. Anderson, A. Lee, T. M. Roberts, and T A. Springer. 1990. Transfection of cells from patients with leukocyte adhesion deficiency with an integrin β subunit (CD18) restores lymphocyte function-associated antigen-1 expression and function. J. Clin. Invest. 85: 674.
20. Peterson, A., and B. Seed. 1988. Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4. Cell 54:65.
21. Shafren, D. R., G. A. Tonnock, and T K. Roberts 1995. Development and application of an ELISA technique for detection of antibody to avian encephalomyelitis viruses. Res. Vet. Sci 46.95.
22. v integrin expression on cultured human macrophages Proc. Nad. Acad. Sci USA 90:2517.
23. Vedder, N. B., and J. M. Harlan. 1988. Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium. J. Clin. Invest. 81.676.