Cocaine and exercise: Alteration in carbohydrate metabolism in adrenodemedullated rats

Journal of Applied Physiology

Volumn 80, Issue 1, 1996, Pages 124-132

  Ojuka, Edward O ^a   Bell, John D ^a   Fellingham, Gilbert W ^a   Conlee, Robert K ^a  

^a BRIGHAM YOUNG UNIVERSITY   (United States)

Author keywords

blood glucose; catecholamines; dopamine; epinephrine; lactic acid; muscle glycogen; norepinephrine

Indexed keywords

ADRENALIN; CATECHOLAMINE; COCAINE; CORTICOSTEROID; DOPAMINE; GLUCOSE; GLYCOGEN; LACTIC ACID; NORADRENALIN;

ADRENAL MEDULLA; ADRENAL MEDULLECTOMY; ADRENALIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CATECHOLAMINE BLOOD LEVEL; CATECHOLAMINE RELEASE; CONTROLLED STUDY; CORTICOSTEROID BLOOD LEVEL; EXERCISE; GLUCOSE BLOOD LEVEL; GLYCOGEN MUSCLE LEVEL; GLYCOGENOLYSIS; LACTATE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASTUS LATERALIS MUSCLE;

EID: 0030047898     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.80.1.124     Document Type: Article

References (35)

1. Aragon, J. J,. K. Thornheim, and J. M. Lowenstein. On a possible role of IMP in the regulation of phosphorylase activity in skeletal muscle. FEBS Lett. 117, Suppl.: K56-K64, 1980.
2. Arnall, D. A., J. C. Marker, R. K. Conlee, and W. W. Winder. Effect of infusing epinephrine on liver and muscle glycogenolysis during exercise in rats. Am. J. Physiol. 250 (Endocrinol. Metab. 13): E641-E650, 1986.
3. Bracken, M. E., D. R. Bracken, A. G. Nelson, and R. K. Conlee. The effect of cocaine on exercise endurance and glycogen use in rats. J. Appl. Physiol. 64: 884-887, 1988.
4. Braiden, R. W., G. W. Fellingham, and R. K. Conlee. Effects of cocaine on glycogen metabolism and endurance during high intensity exercise. Med. Sci. Sports Exercise 26: 695-700. 1994.
5. 2+. J. Biol. Chem. 246: 1961-1967, 1971.
6. Carlsen, K. I., J. C. Marker, D. A. Arnall, M. L. Terry, H. T. Yang, L. G. Lindsay, M. E. Bracken, and W. W. Winder. Epinephrine is unessential for stimulation of liver glycogenolysis during exercise. J. Appl. Physiol. 58: 544-548, 1985.
7. Chasiotis, D. Role of cyclic AMP and inorganic phosphate in the regulation of muscle glycogenolysis during exercise. Med. Sci. Sports Exercise 20: 545-550, 1988.
8. Chiueh, C. C., and I. J. Kopin. Centrally mediated release by cocaine of endogenous epinephrine and norepinephrine from the sympathoadrenal medullary system of unanesthetized rats. J. Pharmacol. Exp. Ther. 205: 148-154, 1978.
9. Clutter, W. E., D. M. Bier, S. D. Shah, and P. E. Cryer. Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man. J. Clin. Invest. 66: 94-101, 1980.
10. Conlee, R. K., D. W. Barnett, K. P. Kelly, and D. H. Han. Effect of cocaine on plasma catecholamine and muscle glycogen concentrations during exercise in the rat. J. Appl. Physiol. 70: 1323-1327, 1991.
11. Conlee, R. K., J.A. McLane, M. J. Rennie, W. W. Winder, and J. O. Holloszy. Reversal of phosphorylase activation in muscle despite continued contractile activity. Am. J. Physiol. 237 (Regulatory Integrative Comp. Physiol. 6): R291-R296, 1979.
12. Exton, J. H., S. B. Lewis, R. J. Ho, G. A. Robison, and C. R. Park. The role of cyclic AMP in the interaction of glucagon and insulin in the control of liver metabolism. Ann. NY Acad. Sci. 185: 85-100, 1971.
13. Gilman, A. G. A protein binding assay for adenosine 3′,5′-cyclic monophosphate. Proc. Natl. Acad. Sci. USA 67: 305-312, 1970.
14. Hassid, W. Z., and S. Abraham. Chemical procedures for analysis of polysaccharide. Methods Enzymol. 3: 35-36, 1957.
15. Hue, L., and M. Rider. Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues. Biochem. J. 245: 313-324 1987
16. Kelly, K. P., D. H. Han, G. W. Fellingham, W. W. Winder, and R. K. Conlee. Cocaine and exercise: physiological responses of cocaine-conditioned rats. Med. Sci. Sports Exercise 27: 65-72, 1995.
17. Kiristy-Roy, J. A., J. B. Halter, S. M. Gordon, J. M. Smith, and L. C. Terry. Role of the central nervous system in hemodynamic and sympathoadrenal responses to cocaine in rats. J. Pharmacol. Exp. Ther. 255: 154-160, 1990.
18. Langer, S. Z., and M. A. Enero. The potentiation of responses to adrenergic nerve stimulation in the presence of cocaine: its relationship to the metabolic fate of released norepinephrine. J. Pharmacol. Exp. Ther. 191: 431-443, 1974.
19. Lau, C. E., F. Ma, and J. L. Falk. Simultaneous determination of cocaine and its metabolites with caffeine in rat serum microsamples by high-performance liquid chromatography. J. Chromatogr. 532: 95-103, 1990.
20. Marker, J. C., D. A. Arnall, R. K. Conlee, and W. W. Winder. Effect of adrenodemedullation on metabolic responses to high-intensity exercise. Am. J. Physiol. 251 (Regulatory Integrative Comp. Physiol. 20): R552-R559, 1986.
21. Mejer, L. E., and R. C. Blanchard. Fluorometric determination of plasma 11-hydroxycorticosteroids. Clin. Chem. 19: 710-717, 1973.
22. Rail, J. A., and P. A. Wahr. Molecular aspects of muscular contraction. In: Principles of Exercise Biochemistry (2nd rev. ed.), edited by J. R. Poortmans. Basel: Karger, 1993, p. 13.
23. Remie, R., and J. Zaagsma. A new technique for the study of vascular presynaptic receptors in freely moving rats. Am. J Physiol. 251 (Heart Circ. Physiol. 20): H463-H467, 1986.
24. Ren, J., and E. Hultman. Regulation of glycogenolysis in human skeletal muscle. J. Appl. Physiol. 67: 2243-2248, 1989.
25. Richter, E. A., N. B. Ruderman, H. Gavras, E. R. Belur, and H. Galbo. Muscle glycogenolysis during exercise: dual control by epinephrine and contractions. Am. J. Physiol. 242 (Endocrinol. Metab. 5): E25-E32, 1982.
26. Ritchie, J. M., and N. M. Greene. Local anesthetics. In: The Pharmacological Basis of Therapeutics, edited by A G. Gilman, L. S. Gilman, T. W. Rail, and F. Murad. New York: Macmillan, 1985, p. 302-321.
27. Saltin, B., and P. D. Gollnick. Skeletal muscle adaptability: significance for metabolism and performance. In: Handbook of Physiology. Skeletal Muscle. Bethesda, MD: Am. Physiol. Soc., 1983, sect. 10, chapt. 19, p. 555-631.
28. Scheurink, A. J. W., A. B Steffens, H. Bouritius, G. H. Dreteler, R. Bruntink, R. Remie, and J. Zaagsma. Adrenal and sympathetic catecholamines in exercising rats. Am. J. Physiol. 257 (Regulatory Integrative Camp. Physiol. 26): R155-R160, 1989.
29. Spriet, L. L., K. Soderlund, M. Bergstrom, and E. Hultman. Skeletal muscle glycogenolysis, glycolysis, and pH during electrical stimulation in man. J. Appl. Physiol. 62: 616-621, 1987.
30. Stainsby, W. N., C. Sumners, and G. M. Andrew. Plasma catecholamines and their effect on blood lactate and muscle lactate output. J. Appl. Physiol. 57: 321-325, 1984.
31. Van Schaftingen, E., and H. G. Hers. Fructose 2,6-bisphosphate in relation with the resumption of metabolic activity in slices of Jerusalem artichoke tubers. FEBS Lett. 164: 195-200, 1983.
32. Wiggins, R. C., C. Rolsten, B. Ruiz, and C. M. Davis. Pharmacokinetics of cocaine: basic studies of route, dosage, pregnancy and lactation. Neurotoxicology. 10: 367-381, 1989
33. Winder, W. W., and C. Duan. Control of fructose 2,6-diphosphate in muscle of exercising fasted rats. Am. J. Physiol. 262 (Endocrinol. Metab. 25): E919-E924, 1992.
34. Winder, W. W., M. L. Terry, and V. M. Mitchell. Role of plasma epinephrine in fasted exercising rats. Am. J. Physiol. 248 (Regulatory Integrative Comp. Physiol. 17): R302-R307, 1985.
35. Zahniser, R. N., and J. Peris. Neurochemical mechanisms of cocaine-induced sensitization. In: Cocaine: Pharmacology, Physiology, and Clinical Strategies, edited by J. M. Lakoski, M. P. Galloway, and F. J. White. Ann Arbor, MI: CRC Press, 1992, p. 229-261.