Translocations in solid tumours

Current Opinion in Genetics and Development

Volumn 6, Issue 1, 1996, Pages 71-75

  Cooper, Colin S ^a  

^a Haddow Laboratories   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP PROTEIN; HYBRID PROTEIN;

BENIGN TUMOR; CANCER DIAGNOSIS; CANCER GENETICS; CHONDROSARCOMA; CHROMOSOME 12; CHROMOSOME 18; CHROMOSOME TRANSLOCATION; CYTOGENETICS; EWING SARCOMA; HUMAN; LIPOMA; MOLECULAR CLONING; PRIORITY JOURNAL; RHABDOMYOSARCOMA; SHORT SURVEY; SOLID TUMOR; SYNOVIAL SARCOMA; UTERUS MYOMA; X CHROMOSOME;

EID: 0030047758     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(96)90013-1     Document Type: Article

References (11)

1. Enzinger FM, Weiss SW: Soft Tissue Tumours, edn 2. St Louis: Mosby; 1988.
2. Limon J, Mrozek K, Mandahl N, Nedoszytko B, Verhest A, Rys J, Niezabitowski A, Babinska M, Nosek H, Ochalek T et al.: Cytogenetics of synovial sarcomas: presentation of ten new cases and review of the literature. Genes Chroms Cancer 1991, 3:338-345.
3. Knight JC, Reeves BR, Smith S, Clark J, Fisher C, Fletcher CDM, Gusterson BA, Cooper CS: Cytogenetic and molecular analysis of synovial sarcoma. Int J Oncol 1992, 1:747-752.
4. Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP, Abe S, Gusterson BA, Cooper CS: The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome. Oncogene 1994, 9:1447-1453.
5. De Leeuw B, Suijkerbuijk RF, Weghuis DO, Meloni AM, Stenman G, Kindblom LG, Balemans M, Van den Berg E, Molenaar WM, Sandberg AA et al.: Distinct Xp11.2 breakpoint regions in synovial sarcoma revealed by metaphase and interphase FISH: relationship to histologic subtype. Cancer Genet Cytogenet 1994, 73:89-94.
6. Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM-L, Gusterson BA, Cooper CS: Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Nature Genet 1994, 7:502-508.
7. This paper reports the cloning of the genes involved in the t(X;18)(p11.2;q12.2) synovial sarcoma translocation. This translocation results in the fusion of the chromosome 18 SYT gene to the chromosome X SSX gene giving rise to a chimaeric gene that encodes a SYT-SSX fusion protein. Both SYT and SYT-SSX sequences failed to exhibit homology to known gene sequences.
8. Crew AJ, Clark J, Fisher C, Gill S, Grimer R, Chand A, Shipley J, Gusterson BA, Cooper CS: Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to Krüppel-associated box in human synovial sarcoma. EMBO J 1995, 14:2333-2340.
9. The cytogenetically defined translocation t(X;18)(p11.2;q11.2) found in synovial sarcoma is shown in this study to result in the fusion of the chromosome 18 SYT gene to either of two distinct SSX1 or SSX2 genes at Xp11.2. SSX1 and SSX2 encode closely related proteins that exhibit homology to the Krüppel-associated box transcriptional repressor region. SYT-SSX1 and SYT-SSX2 fusions were found in 29 out of 30 synovial sarcomas studied.
10. Zucman J, Melot T, Desmaze C, Ghysdael J, Plougastel B, Peter M, Zucker J-M, Triche TJ, Sheer D, Turc-Carel C et al.: Combinatorial generation of variable fusion proteins in the Ewings family of tumours. EMBO J 1993, 12:4481-4487.
11. Sorensen PH, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ, Denny CT: A second Ewings sarcoma translocation t(21;22) fuses the EWS gene to another ETS-famlly transcription factor ERG. Nature Genet 1994, 6:146-151.