Erythrocyte membrane fluidity in adult polycystic kidney disease: Difference between intact cells and ghost membranes

European Journal of Clinical Investigation

Volumn 26, Issue 2, 1996, Pages 171-173

  Vareesangthip, K ^a   Thomas, T H ^a   Tong, P ^a   Wilkinson, R ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Cytoskeleton; Erythrocyte; Membrane fluidity; Polycystic kidney disease

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSKELETON; ERYTHROCYTE GHOST; ERYTHROCYTE MEMBRANE; HUMAN; KIDNEY POLYCYSTIC DISEASE; MEMBRANE FLUIDITY; PRIORITY JOURNAL;

EID: 0030047625     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1996.121259.x     Document Type: Article

References (12)

1. The European Polycystic Kidney Disease Consortium. The polycystic kidney disease 1 gene encodes a 24kb transcript and lies within a duplicated region on chromosome 16. Cell 1994;77:1-20.
2. Kimberling WJ, Kumar S, Gabow PA, Kenyon JB, Conolly L, Somlo S. Autosomal dominant polycystic kidney disease: localization of the second gene to chromosome 4q13-q23. Genomics 1993;18:467-72.
3. van Adelsberg JS, Frank D. The PKD1 gene produces a developmentally regulated protein in mesenchyme and vasculature. Nature Med 1995;1:359-64.
4. Harris PC, Germino G, Klinger K, Landes G, van Adelsberg J. The PKD1 gene product. Nature Med 1995;1:493.
5. Calvet JP. Polycystic kidney disease: Primary extracellular matrix abnormality or defective cellular differentiation? Kidney Int 1993;43:101-8.
6. +-ATPase: mislocation to apical plasma membranes in polycystic kidney disease epithelia. Am J Physiol 1991;260:F420-30.
7. Wilson PD, Sherwood AC. Tubulocystic epithelium. Kidney Int 1991;39:450-63.
8. Woo DDL, Miao SYP, Pelayo JC, Woolf AS. Taxol inhibits progression of congenital polycystic kidney disease. Nature 1994;368:750-3.
9. + countertransport kinetics in adult polycystic kidney disease: evidence for a cytoskeletal defect in the erythrocyte. Nephrol Dial Transplant (in press).
10. Dodge JT, Mitchell C, Hanahan D. The preparation and characteristics of haemoglobin free ghosts of human erythrocytes. Arch Biochem Biophys 1963;100:119-30.
11. Tong P, Thomas TH, Wilkinson R. Membrane fluidity is different in intact erythrocytes and ghost membranes. Biochem Med Metab Biol 1994;52:132-5.
12. Bennett V, Branton D. Selective association of spectrin with the cytoplasmic surface of human erythrocyte plasma membranes. J Biol Chem 1977;252:2753-3.